Article
Microbiology
Cinthia V. Soberanes-Gutierrez, Ernesto Perez-Rueda, Jose Ruiz-Herrera, Edgardo Galan-Vasquez
Summary: Cell death process can be classified into three patterns: apoptosis, autophagy and necrosis. The transcriptional regulatory network of U. maydis was reconstructed based on homology inferences from other fungi, revealing key transcription factors and functional modules related to diverse cellular process including cell death. Selected genes were found to be downregulated at 72 h, marking the onset of cell death process in U. maydis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yue-ling Peng, Ling-xiao Wang, Mu-ye Li, Li-ping Liu, Rong-shan Li
Summary: This study identified four necroptosis-related genes and established a prognostic risk model that could potentially predict prognosis and response to chemotherapy and immunotherapy in hepatocellular carcinoma (HCC) patients in the future.
Article
Cell Biology
Jia-Heng Zhang, Shi-Yu Ni, Ya-Ting Tan, Jia Luo, Shu-Chao Wang
Summary: By conducting bibliometric analyses, this study explores the research trends and hotspots of Pin1 and cell death. The results indicate that the research on Pin1 and cell death has been increasing annually since 2001, but growth after 2014 appears to be stagnant. The cooperation between core institutions needs to be strengthened, and recently, Fujian Medical University in China has emerged as the institution with the highest citation count. Further research is required to understand the role of Pin1 in cell death and to identify new research hotspots. Future studies are likely to focus on disease treatment using Pin1 inhibitors, before breakthroughs are made in understanding the molecular mechanisms or signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Yan Zhang, Suliman Khan, Yang Liu, Ruiyi Zhang, Hongmin Li, Guofeng Wu, Zhouping Tang, Mengzhou Xue, V. Wee Yong
Summary: This review summarizes the knowledge of cell death induced by intracerebral hemorrhage (ICH), with a focus on apoptosis and necrosis. It also discusses the involvement of recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos in ICH. Treatment strategies to mitigate brain injury based on specific cell death pathways after ICH are also summarized.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Virology
Shannic-Le Kerr, Cynthia Mathew, Reena Ghildyal
Summary: Rhinoviruses are common causes of the common cold and can lead to more severe diseases in lower respiratory tract infections. These viruses hijack host cell pathways to suppress antiviral responses, and the mechanism of how they exit infected cells remains unclear.
Review
Cell Biology
Lawrence M. Schwartz
Summary: Cell death is a normal and essential component of development and homeostasis, but dysregulation of this process underlies most human diseases. Autophagy is a process mediated by the formation of double membrane vesicles, which allows cells to survive stresses and may also mediate cell death during development and pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jerome Estaquier, Germain Gillet, Isabelle Guenal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stephen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernar Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Lu Poyet, Muriel Priault, Jean-Ehrlan Ricci, Franck B. Riquet, Santos A. Susin, Magal Suzanne, Pierre Vacher, Ludivine Walter, Bertran Mollereau
Summary: Since the Nobel Prize was awarded more than twenty years ago for discovering the core apoptotic pathway in C. elegans, researchers around the world have conducted extensive research on apoptosis and various other forms of regulated cell death. Although there are still many aspects of regulated cell death that need to be clarified in specific cell subtypes and disease conditions, the last decade has seen the description of multiple cell death modalities, some of which have been successfully used in clinical therapy. To keep research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN), which is at the forefront of emerging topics in cell death research. These research efforts will enhance our mechanistic knowledge of regulated cell death and its therapeutic applications in the coming years.
Article
Immunology
Wenhao Xu, Hai-Jia Tang, Aihetaimujiang Anwaier, Wangrui Liu, Xi Tian, Jiaqi Su, Shiyin Wei, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye
Summary: This study evaluated the transcriptomic profile of cell death pathways in bladder cancer patients and found that patients with high cell-death index (CDI) had a higher risk of mortality. These high-risk patients also exhibited an immunoevasive tumor microenvironment characterized by increased tumor-associated macrophage infiltration and expression of immune checkpoints. These findings provide important clinical and immunological insights for the management of bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Liuhua Zhou, Jiateng Sun, Lingfeng Gu, Sibo Wang, Tongtong Yang, Tianwen Wei, Tiankai Shan, Hao Wang, Liansheng Wang
Summary: Abnormalities in programmed cell death signaling cascades play a crucial role in the development and progression of cardiovascular diseases, leading to excessive cardiac remodeling and heart failure. Timely activation of cell death pathways post-injury can help in repairing cardiac structure and function. Drugs targeting key players in cell death signaling pathways may hold potential for future therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Ourlad Alzeus G. Tantengco, Joy Vink, Paul Mark B. Medina, Ramkumar Menon
Summary: Oxidative stress induced reactive oxygen species production in cervical cells, promoting cell death and inflammation mediated by p38 mitogen-activated protein kinases activation.
BIOLOGY OF REPRODUCTION
(2021)
Review
Microbiology
Erika Grosfeld, Victoria A. Bidiuk, Olga Mitkevich, Eslam S. M. O. Ghazy, Vitaliy V. Kushnirov, Alexander Alexandrov
Summary: The study on cell death in yeast, especially Saccharomyces cerevisiae, may provide valuable insight into cell death mechanisms. However, the lack of clear classification of cell death types and the differences in experimental setups hinder direct comparisons between different stimuli. Future studies may benefit from side-by-side comparisons of various cell death-inducing stimuli using existing and novel markers.
Review
Immunology
Erandi Perez-Figueroa, Pablo Alvarez-Carrasco, Enrique Ortega, Carmen Maldonado-Bernal
Summary: Neutrophils play a crucial role in innate immune response by executing various effector functions. When activated, they undergo cell death processes to ensure the proper elimination of pathogens and damaged cells, contributing to timely resolution of inflammation. Neutrophils' cell death mechanisms include apoptosis, pyroptosis, necrosis, and others, ultimately maintaining homeostasis in the organism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Pan Li, Xiao-Rong Dong, Bei Zhang, Xin-Tong Zhang, Jing-Zhuo Liu, De-Sheng Ma, Li Ma
Summary: Cell death is a crucial process for maintaining the morphology and function of cells, with different modes of cell death having varying effects on different organs. The heart, being the most important organ, is a particular focus for studying the mechanisms of cell death and its relationship with heart diseases. Research on heart therapy is discussed in the context of pathogenesis.
CHINESE MEDICAL JOURNAL
(2021)
Review
Neurosciences
Junhui Chen, Mingchang Li, Zhuanghua Liu, Yuhai Wang, Kun Xiong
Summary: SAH is a common cerebrovascular disease with high disability and mortality rates worldwide. The pathophysiological mechanisms involved in an aneurysm rupture in SAH are complex, including early brain injury and delayed brain injury. Multiple cell death pathways are stimulated during the pathogenesis of brain damage, such as necrosis, apoptosis, autophagy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Zhi Lin, Fei Long, Rui Kang, Daniel J. Klionsky, Minghua Yang, Daolin Tang
Summary: This article provides a comprehensive summary of the latest research on the role and potential mechanisms of different lipids in regulating regulated cell death processes, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy.
Article
Biochemistry & Molecular Biology
C. K. McPhee, B. M. Balgley, C. Nelson, J. H. Hill, Y. Batlevi, X. Fang, C. S. Lee, E. H. Baehrecke
CELL DEATH AND DIFFERENTIATION
(2013)
Article
Biochemistry & Molecular Biology
Charles Nelson, Victor Ambros, Eric H. Baehrecke
Article
Cell Biology
Panagiotis D. Velentzas, Lejie Zhang, Gautam Das, Tsun-Kai Chang, Charles Nelson, William R. Kobertz, Eric H. Baehrecke
DEVELOPMENTAL CELL
(2018)
Article
Developmental Biology
Charles Nelson, Victor Ambros
Article
Genetics & Heredity
Charles Nelson, Victor Ambros
Summary: The let-7 gene encodes a highly conserved microRNA crucial for cell fate specification and developmental progression in animals. Some nematode species within the Caenorhabditis genus lack let-7 gene, but they possess let-7-family microRNAs that target LIN-41 mRNA.
G3-GENES GENOMES GENETICS
(2021)
