Cardiac glycosides correct aberrant splicing ofIKBKAP-encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3

IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia

(2012) Paula Dietrich et al.   HUMAN MOLECULAR GENETICS

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

(2012) Rong Jia et al.   International Journal of Biological Sciences

Nutraceutical-mediated restoration of wild-type levels of IKBKAP-encoded IKAP protein in familial dysautonomia-derived cells

(2012) Sylvia L. Anderson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

(2012) Gabsang Lee et al.   NATURE BIOTECHNOLOGY

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms

(2012) S. Erkelenz et al.   RNA

The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes

(2012) Minna-Liisa Änkö et al.   GENOME BIOLOGY

Loss of exon identity is a common mechanism of human inherited disease

(2011) T. Sterne-Weiler et al.   GENOME RESEARCH

Digitoxin-Induced Cytotoxicity in Cancer Cells Is Mediated through Distinct Kinase and Interferon Signaling Networks

(2011) I. Prassas et al.   MOLECULAR CANCER THERAPEUTICS

Role of SFRS13A in low-density lipoprotein receptor splicing

(2010) I-Fang Ling et al.   HUMAN MUTATION

Elongator function in tRNA wobble uridine modification is conserved between yeast and plants

(2010) Constance Mehlgarten et al.   MOLECULAR MICROBIOLOGY

Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer

(2010) X He et al.   ONCOGENE

Phosphatidylserine Increases IKBKAP Levels in Familial Dysautonomia Cells

(2010) Hadas Keren et al.   PLoS One

Olfactory Stem Cells, a New Cellular Model for Studying Molecular Mechanisms Underlying Familial Dysautonomia

(2010) Nathalie Boone et al.   PLoS One

Cardiac Glycosides Inhibit p53 Synthesis by a Mechanism Relieved by Src or MAPK Inhibition

(2009) Z. Wang et al.   CANCER RESEARCH

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways

(2009) Vânia Gonçalves et al.   HUMAN MOLECULAR GENETICS

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Can the Therapeutic Efficacy of Tocotrienols in Neurodegenerative Familial Dysautonomia Patients Be Measured Clinically?

(2008) Berish Y. Rubin et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

(2008) R. B. Zavareh et al.   CANCER RESEARCH

Alternative Splicing and Tumor Progression

(2008) Claudia Ghigna et al.   CURRENT GENOMICS

The emerging role of splicing factors in cancer

(2008) Ana Rita Grosso et al.   EMBO REPORTS

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration

(2008) L. D. Johansen et al.   JOURNAL OF CELL SCIENCE

SRp20 and CUG-BP1 Modulate Insulin Receptor Exon 11 Alternative Splicing

(2008) S. Sen et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of Mouse Ikbkap, a Subunit of Elongator, Leads to Transcriptional Deficits and Embryonic Lethality That Can Be Rescued by Human IKBKAP

(2008) Y.-T. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity

(2008) T. Mijatovic et al.   MOLECULAR CANCER THERAPEUTICS

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

(2008) P. Stoilov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA