Up-regulation of survivin by AKT and hypoxia-inducible factor 1α contributes to cisplatin resistance in gastric cancer

Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells

(2013) Mamoru Tanaka et al.   BMC CANCER

Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice

(2013) Anahid Ehteda et al.   BMC CANCER

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

(2013) Howard A. Burris   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Angiopoietin2 enhances doxorubin resistance in HepG2 cells by upregulating survivin and Ref-1 via MSK1 activation

(2013) Tao Li et al.   CANCER LETTERS

STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells

(2013) Zheng Wei et al.   CELLULAR SIGNALLING

ABT-737 Synergizes with Arsenic Trioxide to Induce Apoptosis of Gastric Carcinoma Cells In Vitro and In Vivo

(2013) Xp Sun et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Suppression of Survivin Induced by a BCR-ABL/JAK2/STAT3 Pathway Sensitizes Imatinib-Resistant CML Cells to Different Cytotoxic Drugs

(2013) S. Stella et al.   MOLECULAR CANCER THERAPEUTICS

Targeting survivin in cancer

(2012) Dario C. Altieri   CANCER LETTERS

Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer

(2012) Q. Wang et al.   CANCER RESEARCH

Secretory clusterin contributes to oxaliplatin resistance by activating Akt pathway in hepatocellular carcinoma

(2012) Peng Xiu et al.   CANCER SCIENCE

HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer

(2012) Yanbin Liu et al.   CARCINOGENESIS

AKT as locus of cancer multidrug resistance and fragility

(2012) Ziv Radisavljevic   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia inducible factor-1α-mediated activation of survivin in cervical cancer cells

(2012) Haitao Bai et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

YM155 Reverses Cisplatin Resistance in Head and Neck Cancer by Decreasing Cytoplasmic Survivin Levels

(2012) B. Kumar et al.   MOLECULAR CANCER THERAPEUTICS

Thimerosal-Induced Apoptosis in Mouse C2C12 Myoblast Cells Occurs through Suppression of the PI3K/Akt/Survivin Pathway

(2012) Wen-Xue Li et al.   PLoS One

Downregulation of Skp2 inhibits the growth and metastasis of gastric cancer cells in vitro and in vivo

(2012) Zheng Wei et al.   TUMOR BIOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells

(2011) Christoph Wohlkoenig et al.   CANCER LETTERS

Downregulating hypoxia-inducible factor-2α improves the efficacy of doxorubicin in the treatment of hepatocellular carcinoma

(2011) Changjun He et al.   CANCER SCIENCE

Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

(2011) M. E. Balasis et al.   CLINICAL CANCER RESEARCH

Regulation of survivin by PI3K/Akt/p70S6K1 pathway

(2010) Peng Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

(2010) Chun Hei Antonio Cheung et al.   Cancer Cell International

Antisense HIF-1α prevents acquired tumor resistance to angiostatin gene therapy

(2010) X Sun et al.   CANCER GENE THERAPY

Distinct Biological Roles for the Akt Family in Mammary Tumor Progression: Figure 1.

(2010) Rachelle L. Dillon et al.   CANCER RESEARCH

HIF-1 and HIF-2 transcription factors — Similar but not identical

(2010) Agnieszka Loboda et al.   MOLECULES AND CELLS

Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB

(2010) Nadine Rohwer et al.   PLoS One

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia-inducible Transcription Factor-2α in Endothelial Cells Regulates Tumor Neovascularization through Activation of Ephrin A1

(2008) Toshiharu Yamashita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation

(2008) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial

(2008) Wasaburo Koizumi et al.   LANCET ONCOLOGY

The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

(2007) Matthew D. Hall et al.   Annual Review of Pharmacology and Toxicology