Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes

Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines

(2012) Aleš Špes et al.   BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cluster Sorting Protein-2 (PACS-2)

(2012) Nathan W. Werneburg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice

(2012) Xiang Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

(2012) Francois Gonzalvez et al.   MOLECULAR CELL

Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion

(2011) Sarah Shirley et al.   Recent Patents on Anti-Cancer Drug Discovery

Activation and Specificity of Human Caspase-10

(2010) Katherine Wachmann et al.   BIOCHEMISTRY

Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway

(2010) O. Vondalova Blanarova et al.   CARCINOGENESIS

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

(2010) C Oberle et al.   CELL DEATH AND DIFFERENTIATION

The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation

(2010) Y.H. Zeidan et al.   CURRENT MOLECULAR MEDICINE

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation

(2010) Annie Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

TRAIL receptor signaling and therapeutics

(2010) Junaid Abdulghani et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ceramide-rich platforms in transmembrane signaling

(2010) Branka Stancevic et al.   FEBS LETTERS

Phosphorylation of Caspase-8 (Thr-263) by Ribosomal S6 Kinase 2 (RSK2) Mediates Caspase-8 Ubiquitination and Stability

(2010) Cong Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into apoptosis signaling by Apo2L/TRAIL

(2010) F Gonzalvez et al.   ONCOGENE

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant Liver Cell Lines

(2009) Yuko Akazawa et al.   GASTROENTEROLOGY

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells

(2009) S White-Gilbertson et al.   ONCOGENE

Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type II cells

(2008) Paola Matarrese et al.   BIOCHEMICAL JOURNAL

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

(2008) Aurélie Rossin et al.   BIOCHEMICAL JOURNAL