Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

(2012) O. Criado et al.   HUMAN MOLECULAR GENETICS

Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25by AMP-activated protein kinase

(2011) Carlos Romá-Mateo et al.   BIOCHEMICAL JOURNAL

Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level

(2011) Carlos Romá-Mateo et al.   BMC EVOLUTIONARY BIOLOGY

Phosphate Incorporation during Glycogen Synthesis and Lafora Disease

(2011) Vincent S. Tagliabracci et al.   Cell Metabolism

Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

(2011) Jordi Valles-Ortega et al.   EMBO Molecular Medicine

Structural and evolutionary aspects of two families of non-catalytic domains present in starch and glycogen binding proteins from microbes, plants and animals

(2011) Štefan Janeček et al.   ENZYME AND MICROBIAL TECHNOLOGY

Identification and characterization of novel splice variants of the human EPM2A gene mutated in Lafora progressive myoclonus epilepsy

(2011) Deepti Dubey et al.   GENOMICS

Malin and laforin are essential components of a protein complex that protects cells from thermal stress

(2011) S. Sengupta et al.   JOURNAL OF CELL SCIENCE

Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis

(2011) Jaiprakash Sharma et al.   NEUROBIOLOGY OF DISEASE

Laforin, a Dual Specificity Phosphatase Involved in Lafora Disease, Is Present Mainly as Monomeric Form with Full Phosphatase Activity

(2011) Vikas V. Dukhande et al.   PLoS One

PTG Depletion Removes Lafora Bodies and Rescues the Fatal Epilepsy of Lafora Disease

(2011) Julie Turnbull et al.   PLoS Genetics

Glycogen hyperphosphorylation underlies lafora body formation

(2010) Julie Turnbull et al.   ANNALS OF NEUROLOGY

Sequestration of chaperones and proteasome into Lafora bodies and proteasomal dysfunction induced by Lafora disease-associated mutations of malin

(2010) Sudheendra N.R. Rao et al.   HUMAN MOLECULAR GENETICS

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

(2010) Carmen Aguado et al.   HUMAN MOLECULAR GENETICS

Genetic Depletion of the Malin E3 Ubiquitin Ligase in Mice Leads to Lafora Bodies and the Accumulation of Insoluble Laforin

(2010) Anna A. DePaoli-Roach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Laforin–Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase β Subunits

(2010) Daniel Moreno et al.   MOLECULAR BIOLOGY OF THE CELL

Escherichia coli expression, refolding and characterization of human laforin

(2010) Pedro Castanheira et al.   PROTEIN EXPRESSION AND PURIFICATION

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Conservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organism

(2009) Matthew S Gentry et al.   BMC EVOLUTIONARY BIOLOGY

Deletions and missense mutations of EPM2A exacerbate unfolded protein response and apoptosis of neuronal cells induced by endoplasm reticulum stress

(2009) Y. Liu et al.   HUMAN MOLECULAR GENETICS

Lafora progressive myoclonus epilepsy: A meta-analysis of reported mutations in the first decade following the discovery of theEPM2AandNHLRC1genes

(2009) Shweta Singh et al.   HUMAN MUTATION

Co-chaperone CHIP Stabilizes Aggregate-prone Malin, a Ubiquitin Ligase Mutated in Lafora Disease

(2009) Sudheendra N. R. Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Phosphorylates R5/PTG, the Glycogen Targeting Subunit of the R5/PTG-Protein Phosphatase 1 Holoenzyme, and Accelerates Its Down-regulation by the Laforin-Malin Complex

(2009) Santiago Vernia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperphosphorylation and Aggregation of Tau in Laforin-deficient Mice, an Animal Model for Lafora Disease

(2009) Rajat Puri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Endoplasmic Reticulum Stress and Decreased Proteasomal Function in Lafora Disease Models Lacking the Phosphatase Laforin

(2009) Santiago Vernia et al.   PLoS One

Lafora disease: insights into neurodegeneration from plant metabolism

(2009) Matthew S. Gentry et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evolution of protein phosphatases in plants and animals

(2008) Greg B. G. Moorhead et al.   BIOCHEMICAL JOURNAL

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Debate: Does genetic information in humans help us treat patients?

(2008) Antonio V. Delgado-Escueta et al.   EPILEPSIA

Modulation of functional properties of laforin phosphatase by alternative splicing reveals a novel mechanism for the EPM2A gene in Lafora progressive myoclonus epilepsy

(2008) D. Dubey et al.   HUMAN MOLECULAR GENETICS

The malin–laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin–proteasome system

(2008) Punitee Garyali et al.   HUMAN MOLECULAR GENETICS

Abnormal Metabolism of Glycogen Phosphate as a Cause for Lafora Disease

(2008) Vincent S. Tagliabracci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laforin Negatively Regulates Cell Cycle Progression through Glycogen Synthase Kinase 3 -Dependent Mechanisms

(2008) R. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH