Article
Oncology
Li-Chun Chang, Chia-Tung Shun, Been-Ren Lin, Silvia Sanduleanu, Weng-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
Summary: A study conducted at the National Taiwan University Hospital from 2005 to 2014 compared the disease-free survival of T1 cancer arising from the rectum versus the colon. The results showed that T1 rectal cancer had a higher risk of recurrence compared to T1 colon cancer, with rectal location being an independent risk factor for recurrence. Further research is needed to explore whether adjuvant therapy or closer surveillance can reduce the risk of recurrence in T1 rectal cancer.
Article
Oncology
Julia Hanevelt, Leon M. G. Moons, Judith E. K. R. Hentzen, Tess M. Wemeijer, Jelle F. Huisman, Wouter H. de Vos Tot Nederveen H. Cappel, Henderik L. van Westreenen
Summary: In the background, CAL-WR procedure is proved to be an effective and safe technique for the primary resection of suspected high-grade dysplasia or T1 colon carcinoma. A retrospective study analyzed 57 patients, and diagnosed 27 patients with pT1 colon carcinoma after CAL-WR, among which 3 cases had histological risk factors for lymph-node metastases and 70% showed deep submucosal invasion (Sm2/Sm3). The overall R0-resection rate for pT1 colon carcinoma was 88.9%, with only 1 minor complication reported.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Reza Mahmoudi, Hassan Dianat-Moghadam, Mansour Poorebrahim, Samaneh Siapoush, Vahdat Poortahmasebi, Reza Salahlou, Mohammad Rahmati
Summary: HER2-based immunotoxins are targeted therapies for human cancer, but further progress is needed in clinical settings.
CANCER CELL INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Guangzhe Pian, Seung Yeop Oh
Summary: This study compared the prognoses of T1-2N0 and T1-2N1 colon cancer patients after curative surgery. The results showed no significant difference in overall survival and disease-free survival between the T1-2N0 and T1-2N1 groups, indicating that T1-2N1 colon cancer has a good prognosis after curative surgery.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Polymer Science
Oznur Akbal Vural, Yesim Tugce Yaman, Serdar Abaci
Summary: This study investigated the development of polydopamine nanoparticle as a drug carrier system for saponin and its use in targeted cancer therapy. The results showed that the system had high loading capacity and sustained release properties, and exhibited enhanced toxicity and cellular uptake compared to non-targeted nanoparticles.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Oncology
Wangxin Yan, Huizhen Zhou, Si Shi, Jixu Lin, Qiangkang Lin
Summary: Younger age, female gender, more lymph nodes harvested, Black race, and higher tumor grade were more prone to be diagnosed with lymph node involvement. The receipt of adjuvant chemotherapy following radical surgery significantly decreased the risk of colon cancer-specific mortality by 33.9% in T1 colon cancer with lymph node involvement.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
G. O. Dovjak, I. Kanbur, F. Prayer, P. C. Brugger, G. M. Gruber, M. Weber, F. Stuhr, B. Ulm, G. J. Kasprian, D. Prayer
Summary: This study compared the visibility of bowel structures and artifacts between breath-hold (BH) and free-breathing (FB) techniques in fetal magnetic resonance imaging (MRI), finding no significant differences in sigmoid and colon visibility, but a slight advantage in cecum visibility for BH technique.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bijoy K. Mohanty, Keri Nichols, Sidney R. Kushner
Summary: This study reveals a complex maturation process for Glu2, Ile1, and Ala1B tRNAs encoded within the rRNA operons in Escherichia coli, which is distinct from previously characterized tRNA processing pathways in Gram-positive bacteria.
MOLECULAR MICROBIOLOGY
(2022)
Review
Oncology
Klaus Metter, Stephanie Ellen Weissinger, Alinda Varnai-Haendel, Karl-Ernst Grund, Franz Ludwig Dumoulin
Summary: Endoscopic resection of early-stage colorectal cancer is sufficient if histopathology indicates a low risk for lymph-node metastasis. Factors associated with lymph-node metastasis, such as tumor infiltration depth into the submucosal layer, may increase the risk. Current resection techniques often result in insufficient submucosal tissue. Therefore, a resection strategy using novel devices should be used.
Article
Surgery
Hiroki Shimizu, Yoshiaki Kuriu, Tomohiro Arita, Jun Kiuchi, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Summary: T4N0 colon cancer has similar oncologic characteristics and survival outcomes to T3N1 colon cancer, but the rate of oxaliplatin adjuvant chemotherapy use is lower in T4N0 patients and they have poorer prognosis.
WORLD JOURNAL OF SURGERY
(2021)
Editorial Material
Microbiology
John T. Wren, Juliane Bubeck Wardenburg
Summary: The development of colorectal cancer is linked to the enteric microbiome, and specific microbial signatures can predict the presence of pre-cancerous polyps.
CELL HOST & MICROBE
(2021)
Article
Immunology
Esther Strating, Mathijs P. P. Verhagen, Emerens Wensink, Ester Duennebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez de la Cruz, Niek A. A. Peters, Joris H. H. Hageman, Mirjam M. C. van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G. G. Elias, Onno Kranenburg
Summary: A co-culture model system of colon cancer organoids and cancer-associated fibroblasts (CAFs) was established, which can recapitulate the histological, biophysical, and immunosuppressive features of aggressive mesenchymal-like human colorectal cancer (CRC). This model can be used to study the mechanisms of immunosuppression and test therapeutic strategies targeting the interaction between CAFs and cancer cells. Furthermore, it can be modified to represent different colon cancer subtypes and (organ-specific) microenvironments.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Sheng-Nan Jia, Ying-Bo Han, Rui Yang, Ze-Cheng Yang
Summary: Colon cancer is a common and highly fatal human cancer. Chemokines, particularly CCL20 and its receptor CCR6, play important roles in the progression of colon cancer. The interaction between CCL20-CCR6 and multiple signaling pathways has a profound effect on colon cancer hepatic metastasis. The elevated levels of CCL20 in colon tumors and metastatic patients indicate the potential of chemokines as diagnostic and prognostic biomarkers for colon cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bijoy K. Mohanty, Sidney R. Kushner
Summary: RNase E initiates the processing of alaW alaX precursor RNA by removing the transcription terminator, and the inability of RNase P to separate the precursor tRNAs leads to their degradation via poly(A) mediated decay pathway. This study provides a comprehensive understanding of the processing pathway of Ala2 tRNA.
MOLECULAR MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Menghan Liu, Jia Yuan, Gongzheng Wang, Nengyi Ni, Qian Lv, Shuangqing Liu, Yufang Gong, Xinya Zhao, Ximing Wang, Xiao Sun
Summary: The shape effect plays a crucial role in designing novel nanomaterials. Manipulating the shape of nanomaterials is an effective approach to optimize their bioactive performance. Nanomaterials with unique shapes have advantages in blood circulation, tumor targeting, cell uptake, and magnetic properties. This review focuses on the recent developments of nanomaterials with different shapes for T-1-T-2 dual-mode MRI, and discusses the mechanism of how shape influences the relaxation of nanomaterials. It also explores the combination of dual-mode MRI nanoprobes and advanced therapeutic strategies, along with the challenges from basic research to clinical transformation.
Article
Plant Sciences
Khawla Missaoui, Zulema Gonzalez-Klein, Diego Pazos-Castro, Guadalupe Hernandez-Ramirez, Maria Garrido-Arandia, Faical Brini, Araceli Diaz-Perales, Jaime Tome-Amat
Summary: Plant non-specific lipid transfer proteins (nsLTPs) are small, basic proteins with a wide distribution in higher plants. They have a stable structure that allows them to bind and transport hydrophobic molecules. These proteins play critical roles in plant development and response to various stresses.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sara Garcia-Linares, Rafael Amigot-Sanchez, Carmen Garcia-Montoya, Diego Heras-Marquez, Carlos Alfonso, Juan Roman Luque-Ortega, Jose G. Gavilanes, Alvaro Martinez-Del-Pozo, Juan Palacios-Ortega
Summary: Sticholysins are pore-forming toxins produced by the sea anemone Stichodactyla helianthus. StnII can enhance the activity of StnI and promote its oligomerization. Analytical ultracentrifugation experiments show that StnI is more prone to oligomerization in water solution, but a small amount of StnII in StnI-StnII mixtures can promote oligomerization.
Article
Multidisciplinary Sciences
Khawla Missaoui, Zulema Gonzalez-Klein, Sonia Jemli, Maria Garrido-Arandia, Araceli Diaz-Perales, Jaime Tome-Amat, Faical Brini
Summary: This study reports the identification and purification of a novel member of the nsLTP2 protein family from durum wheat, TdLTP2. The lipid-binding properties of TdLTP2 were examined in vitro and validated using a molecular docking study. Furthermore, the allergenicity of TdLTP2 was assessed through a clinical trial.
Article
Multidisciplinary Sciences
Diego Pazos-Castro, Zulema Gonzalez-Klein, Alma Yuste Montalvo, Guadalupe Hernandez-Ramirez, Alejandro Romero-Sahagun, Vanesa Esteban, Maria Garrido-Arandia, Jaime Tome-Amat, Araceli Diaz-Perales
Summary: In this study, the two-hit hypothesis of inflammatory diseases was applied to investigate the sensitization of food allergy. It was found that long-term depilation in mice resulted in immunological changes, which were further enhanced by the addition of allergen. The encounter with allergen also led to skin remodeling and infiltration of mucosal tissues. Additionally, the study with human ILC2s demonstrated that allergen could induce a phenotype switch. These findings have important implications for understanding the development of food allergy.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Juan Palacios-Ortega, Diego Heras-Marquez, Rafael Amigot-Sanchez, Carmen Garcia-Montoya, Carlos Torrijos, Diego Laxalde, Jose G. Gavilanes, Sara Garcia-Linares, Alvaro Martinez-del-Pozo
Summary: Spanish or Spanish-speaking scientists constitute a significant group studying pore-forming proteins, with a focus on actinoporins. These proteins can transition from a soluble form to a membrane-bound state, triggering cell death by recognizing specific components in the membrane. Our research team from Universidad Complutense of Madrid has been investigating the role of sterols in this transition process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Guadalupe Hernandez-Ramirez, Diego Pazos-Castro, Zulema Gonzalez-Klein, Jose Luis Resuela-Gonzalez, Sergio Fernandez-Bravo, Lucia Palacio-Garcia, Vanesa Esteban, Maria Garrido-Arandia, Jaime Tome-Amat, Araceli Diaz-Perales
Summary: This study demonstrated that Alt a 1 can induce asthmatic phenotypes in vivo, promoting tissue remodeling and infiltration of CD45+ cells, particularly eosinophils and macrophages (Siglec F+ and F4/80+). Furthermore, the study revealed that Alt a 1 sensitization is mediated by the TLR4-macrophage axis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Diego Pazos-Castro, Clemence Margain, Zulema Gonzalez-Klein, Carmen Yuste-Calvo, Maria Garrido-Arandia, Lucia Zurita, Vanesa Esteban, Jaime Tome-Amat, Araceli Diaz-Perales, Fernando Ponz
Summary: Virus-like particles (VLPs) can be used as potential platforms for delivery of cargos in nanomedicine. In this study, VLPs derived from Turnip mosaic virus (TuMV) were genetically coupled to Pru p 3 to investigate their potential in the treatment of food allergy. The results showed that the VLP-Complex effectively reduced allergic responses in mice without causing toxicity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Ana Maria M. Murillo, Luis G. Valle, Yolanda Ramirez, Maria Jesus Sanchez, Beatriz Santamaria, E. Molina-Roldan, Isabel Ortega-Madueno, Elena Urcelay, Luca Tramarin, Pedro Herreros, Araceli Diaz-Perales, Maria Garrido-Arandia, Jaime Tome-Amat, Guadalupe Hernandez-Ramirez, Rocio L. Espinosa, Maria F. Laguna, Miguel Holgado
Summary: In this study, highly multiplexed diagnostic KITs based on an Interferometric Optical Detection Method were developed to evaluate six COVID-19-related biomarkers. The results showed that specific immunoglobulins, ferritin, and C-reactive protein play important roles in evaluating COVID-19.
Article
Multidisciplinary Sciences
Juan Palacios-Ortega, Rafael Amigot-Sanchez, Carmen Garcia-Montoya, Ana Gorse, Diego Heras-Marquez, Sara Garcia-Linares, Alvaro Martinez-Del-Pozo, J. Peter Slotte
Summary: This study provides evidence for the contact of Sticholysins with phosphatidylcholine lipids and reveals the different effects of cholesterol on each Sticholysin isotoxin in membranes. Additionally, the depth of tryptophan residues of Sticholysins in the bilayer was investigated.
SCIENTIFIC REPORTS
(2022)
Correction
Immunology
Diego Pazos-Castro, Clemence Margain, Zulema Gonzalez-Klein, Marina Amores-Borge, Carmen Yuste-Calvo, Maria Garrido-Arandia, Lucia Zurita, Vanesa Esteban, Jaime Tome-Amat, Araceli Diaz-Perales, Fernando Ponz
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Javier Narbona, Ruben G. Gordo, Jaime Tome-Amat, Javier Lacadena
Summary: Due to its high incidence and mortality, cancer is still a major risk to human health and lifespan. Immunotherapy and immunotoxins have emerged as promising approaches to overcome this global disease. This study designed two non-immunogenic variants of immunotoxins and demonstrated their enhanced antitumor activity and lower immunogenicity compared to the wild-type immunotoxin. These findings provide a step forward in optimizing immunotoxins for improved outcomes in cancer treatment.
Article
Allergy
Jaime Tome-Amat, Zulema Gonzalez-Klein, Diego Pazos-Castro, Jose Luis Resuela-Gonzalez, Gonzalo Vilchez-Pinto, Helena Berreiros-Hortala, Lucia Palacio-Garcia, Sergio Fernandez-Bravo, Vanesa Esteban, Araceli Diaz-Perales, Maria Garrido-Arandia
Review
Allergy
Zulema Gonzalez-Klein, Diego Pazos-Castro, Guadalupe Hernandez-Ramirez, Maria Garrido-Arandia, Araceli Diaz-Perales, Jaime Tome-Amat
Summary: Lipid Transfer Proteins (LTPs) are a widely distributed allergen family that can cause various allergic reactions. Recent studies have shown that the ligands carried by LTPs play a significant role in their allergenic capacity. Research on the role of lipids in allergic sensitization can enhance our understanding of the molecular events leading to allergy.
FRONTIERS IN ALLERGY
(2022)