Article
Biophysics
Sadia Malik, Nida Zaidi, Mohammad Khursheed Siddiqi, Nabeela Majid, Aiman Masroor, Samreen Salam, Rizwan H. Khan
Summary: This study evaluates the anti-amyloidogenic potential of the anti-diabetic drug Vildagliptin (VLD) on human serum albumin fibrillation (HSA). The results suggest that VLD has the ability to inhibit amyloid fibrillation and could potentially be repurposed as a drug candidate for the cure of Alzheimer's disease.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Parveen Salahuddin, Munazza Tamkeen Fatima, Vladimir N. Uversky, Rizwan Hasan Khan, Zeyaul Islam, Mohammad Furkan
Summary: Neurodegenerative diseases are characterized by the abnormal loss of neurons, with common pathogenic mechanisms involving misfolding and aggregation of proteins. Accumulating evidence suggests that amyloid oligomers, not fibrils, are the most toxic species causing AD and PD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Malgorzata Milewska, Andrzej Milewski, Ilona Wandzik, Martina H. Stenzel
Summary: Trehalose glycopolymers have been extensively studied recently and have shown some unique properties. In order to compare their properties, researchers synthesized structurally similar glycopolymers composed of trehalose and sucrose. These glycopolymers have very low content of non-saccharide structural fragments, making their properties strongly influenced by the saccharide moieties. The study comprehensively characterized the glycopolymers, including their tendency to self-assemble, hydrolytic stabilities at different pH, and susceptibility to enzymatic hydrolysis.
Article
Chemistry, Physical
Sadia Malik, Faisal Nabi, Mohammad Khursheed Siddiqi, Aiman Masroor, Malik Hisamuddin, Tajalli Ilm Chandel, Nabeela Majid, Rizwan Hasan Khan
Summary: This study confirms the inhibitory effect of lipophilic FAEE on insulin fibrillation, which can cross the blood brain barrier and stabilize the monomeric state of insulin, thereby preventing the extension of fibrillation.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Anurupa A. Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Kim
Summary: This study evaluated the efficacy of a novel NOX inhibitor in Parkinson's disease (PD) models, and found that the compound improved cell viability, reduced ROS levels, and decreased protein aggregation. Both mouse models treated with the compound showed alleviated motor deficits and reduced protein aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Samuel Pena-Diaz, Javier Garcia-Pardo, Salvador Ventura
Summary: Parkinson's disease is the second most common neurodegenerative disorder worldwide, characterized by protein deposits in dopaminergic neurons. Recent research has identified compounds primarily of an aromatic nature that target a-Syn aggregation. This study provides a historical overview of Parkinson's disease, its molecular aspects, and current trends in small compound development to address a-Syn aggregation. These compounds are promising for the development of effective therapies for Parkinson's disease.
Article
Neurosciences
Daniel Kam Yin Chan, Nady Braidy, Ren Fen Chen, Ying Hua Xu, Steven Bentley, Michal Lubomski, Ryan L. Davis, Jack Chen, Carolyn M. Sue, George D. Mellick
Summary: This study investigated the correlation between plasma levels of alpha-synuclein, anti-alpha-synuclein, and their ratios to amyloid beta-40 in Parkinson's disease diagnosis. A diagnostic algorithm was built using promising biomarkers, and the results were verified in an independent sample. The study showed that the combination of these biomarkers demonstrated promising sensitivity and specificity.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seon-Young Park, Hyejin Yang, Soyoung Kim, Juwon Yang, Hyemin Go, Hyunsu Bae
Summary: This study proposes a strategy for alpha-syn specific Treg expansion and demonstrates its neuroprotective effects on Parkinson's disease in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Gregory P. Williams, Aubrey M. Schonhoff, Asta Jurkuvenaite, Nicole J. Gallups, David G. Standaert, Ashley S. Harms
Summary: Alpha-synuclein is implicated in the activation of the immune system in Parkinson's disease, leading to T cell responses and infiltration into the CNS. Genetic deletion or using immunosuppressive drugs can reduce these damaging T cell responses, suggesting a potential avenue for disease-modifying treatments targeting the immune activation associated with alpha-synuclein pathology.
Article
Biophysics
Helena Ostergaard Rasmussen, Daniel E. Otzen, Jan Skov Pedersen
Summary: Amyloid proteins are present in various organisms due to the stability of their beta-sheet core, with both pathological and functional types existing. Understanding the aggregation process involves acquiring data through multiple techniques simultaneously. The aggregation of functional amyloid FapC involves the formation of oligomers transitioning to fibrils, with further maturation leading to compact fibrils with consistent mass per length information obtained through various methods like SAXS and TEM.
BIOPHYSICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Yu P. Zhang, Evgeniia Lobanova, Derya Emin, Sergey V. Lobanov, Antonina Kouli, Caroline H. Williams-Gray, David Klenerman
Summary: This study introduces a new method for the diagnosis of early Parkinson's disease. The results show that the proportion of soluble alpha-synuclein aggregates can distinguish between Parkinson's disease patients and control groups, with Parkinson's disease patients having a higher proportion of larger and rounder alpha-synuclein aggregates. By combining the number and morphology of the aggregates, a new biomarker with improved accuracy for early Parkinson's disease diagnosis was constructed.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sanduni Wasana Jayaweera, Solmaz Surano, Nina Pettersson, Elvira Oskarsson, Lovisa Lettius, Anna L. Gharibyan, Intissar Anan, Anders Olofsson
Summary: The study demonstrates that TTR can interfere with IAPP amyloid-formation, prolonging the lag-phase and impairing elongation. The interfering ability correlates inversely with the thermodynamic stability of TTR, but not with kinetic stability. TTR's interference ability remains effective in the low pH environment of IAPP-containing granules, but TTR-stabilizing drugs partially weaken its efficacy.
Article
Clinical Neurology
Jia-Li Pu, Chong-Yao Jin, Zhong-Xuan Wang, Yi Fang, Yao-Lin Li, Nai-Jia Xue, Ran Zheng, Zhi-Hao Lin, Yi-Qun Yan, Xiao-Li Si, Ying Chen, Yi Liu, Zhe Song, Ya-Ping Yan, Jun Tian, Xin-Zhen Yin, Bao-Rong Zhang
Summary: The study indicates that patients with Parkinson's disease who carry the APOE ε4 allele may experience faster motor progression, especially in those with high amyloid beta burden. This suggests a potential link between APOE ε4 and rapid motor decline in PD.
MOVEMENT DISORDERS
(2022)
Review
Geriatrics & Gerontology
Jiajun Han, Yaohua Fan, Peipei Wu, Zifeng Huang, Xinrong Li, Lijun Zhao, Yichun Ji, Meiling Zhu
Summary: Parkinson's disease dementia is a common complication of Parkinson's disease that seriously affects patients' health and quality of life. The complex interplay of iron, alpha-synuclein, tau, beta-amyloid, and oxidative stress plays a pivotal role in the mechanism underlying PDD, leading to neuronal protein accumulation, neuroinflammation, and cell death. GSK3 beta is identified as a potential target for the prevention and treatment of PDD due to its central role in regulating the vicious cycle of molecular interactions.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Wenjia Lou, Samuel D. Stimple, Alec A. Desai, Emily K. Makowski, Sibel Kalyoncu, Jesper E. Mogensen, Lotte T. Spang, Desiree J. Asgreen, Arne Staby, Karen Duus, Jan Amstrup, Yulei Zhang, Peter M. Tessier
Summary: Biologics such as peptides and proteins have attractive attributes, but are prone to aggregation. By developing conformation-specific antibodies, a sensitive immunoassay for detecting aggregates has been successfully created. These antibodies not only exhibit high conformational specificity, but also cross-react with amyloid fibrils formed by various polypeptides.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Chemistry, Physical
Prashant N. Jethva, Jayant B. Udgaonkar
JOURNAL OF PHYSICAL CHEMISTRY B
(2017)
Article
Chemistry, Analytical
Pinakin K. Makwana, Prashant N. Jethva, Ipsita Roy
Article
Biochemistry & Molecular Biology
Prashant N. Jethva, Jayant B. Udgaonkar
Article
Neurosciences
Rajeev Kumar Chaudhary, Jay Kardani, Kuljit Singh, Ruchira Banerjee, Ipsita Roy
NEUROMOLECULAR MEDICINE
(2014)
Article
Immunology
Laura A. VanBlargan, John M. Errico, Natasha M. Kafai, Katherine E. Burgomaster, Prashant N. Jethva, Rebecca M. Broeckel, Kimberly Meade-White, Christopher A. Nelson, Sunny Himansu, David Wang, Scott A. Handley, Michael L. Gross, Sonja M. Best, Theodore C. Pierson, Daved H. Fremont, Michael S. Diamond
Summary: The study developed a panel of neutralizing anti-POWV antibodies, some of which exhibit cross-reactivity to other flaviviruses. The experiments showed that these antibodies can protect mice against POWV infection when used as prophylaxis or postexposure therapy, and some antibodies also have protective effects against other tick-transmitted flaviviruses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Arthur S. Kim, Natasha M. Kafai, Emma S. Winkler, Theron C. Jr Jr Gilliland, Emily L. Cottle, James T. Earnest, Prashant N. Jethva, Paulina Kaplonek, Aadit P. Shah, Rachel H. Fong, Edgar Davidson, Ryan J. Malonis, Jose A. Quiroz, Lauren E. Williamson, Lo Vang, Matthias Mack, James E. Jr Jr Crowe, Benjamin J. Doranz, Jonathan R. Lai, Galit Alter, Michael L. Gross, William B. Klimstra, Daved H. Fremont, Michael S. Diamond
Summary: Two poorly neutralizing human monoclonal antibodies, DC2.112 and DC2.315, have been identified as pan-protective against both arthritogenic and encephalitic alphaviruses. These antibodies target a conserved epitope in the E1 protein domain II and offer protection through multiple mechanisms, including inhibiting viral egress and monocyte-dependent Fc effector functions. This finding provides potential targets for pan-alphavirus immunotherapy and vaccine design.
Article
Biochemistry & Molecular Biology
Pooja Malhotra, Prashant N. Jethva, Jayant B. Udgaonkar
