Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -‘trick or treats’?

Making autophagosomes: Localized synthesis of phosphatidylinositol 3-phosphate holds the clue

(2014) Simon Walker et al.   Autophagy

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

(2014) Ruben K. Dagda et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Autophagy: An emerging target for cancer therapy

(2014) Maria Høyer-Hansen et al.   Autophagy

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

(2014) Marie Stampe Ostenfeld et al.   Autophagy

Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy

(2009) Tomohiro Yorimitsu et al.   Autophagy

Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

(2009) David A. Foster   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

(2009) C. S. Beevers et al.   CANCER RESEARCH

Bif-1/Endophilin B1: a candidate for crescent driving force in autophagy

(2009) Y Takahashi et al.   CELL DEATH AND DIFFERENTIATION

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

(2009) N. T. Ihle et al.   MOLECULAR CANCER THERAPEUTICS

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD

Mammalian Target of Rapamycin and S6 Kinase 1 Positively Regulate 6-thioguanine-Induced Autophagy

(2008) X. Zeng et al.   CANCER RESEARCH

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

(2008) N. Fehrenbacher et al.   CANCER RESEARCH

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death

(2008) D Gozuacik et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Toward unraveling membrane biogenesis in mammalian autophagy

(2008) Tamotsu Yoshimori et al.   CURRENT OPINION IN CELL BIOLOGY

E2F1 Inhibits c-Myc-Driven Apoptosis via PIK3CA/Akt/mTOR and COX-2 in a Mouse Model of Human Liver Cancer

(2008) Sara Ladu et al.   GASTROENTEROLOGY

Effect of Rifampicin to Inhibit Rapamycin-Induced Autophagy via the Suppression of Protein Phosphatase 2A Activity

(2008) In-Hoo Park et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

(2008) Takashi Shingu et al.   INTERNATIONAL JOURNAL OF CANCER

Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling

(2008) Craig Stevens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells

(2008) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abl Kinases Regulate Autophagy by Promoting the Trafficking and Function of Lysosomal Components

(2008) Gouri Yogalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism

(2008) E. Y. W. Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

The mTOR pathway and its role in human genetic diseases

(2008) M ROSNER et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

E2F1 regulates autophagy and the transcription of autophagy genes

(2008) S Polager et al.   ONCOGENE

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Scaffold Makes the Switch

(2008) H. G. Dohlman   Science Signaling