A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism

D5 dopamine receptor carboxyl tail involved in D5–D2 heteromer formation

(2013) Brian F. O’Dowd et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

(2013) Melissa L Perreault et al.   NEUROPSYCHOPHARMACOLOGY

A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex

(2012) Melissa L. Perreault et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dopamine D1–D2 Receptor Heteromer in Dual Phenotype GABA/Glutamate-Coexpressing Striatal Medium Spiny Neurons: Regulation of BDNF, GAD67 and VGLUT1/2

(2012) Melissa L. Perreault et al.   PLoS One

Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1–D2 heteromer formation

(2011) Brian F. O’Dowd et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Separation and reformation of cell surface dopamine receptor oligomers visualized in cells

(2011) Brian F. O'Dowd et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance

(2011) Ahmed Hasbi et al.   Molecular Brain

The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons

(2010) Melissa L. Perreault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

(2010) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine D1-D2 Receptor Heteromer-mediated Calcium Release Is Desensitized by D1 Receptor Occupancy with or without Signal Activation

(2010) Vaneeta Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

(2010) Lin Pei et al.   NATURE MEDICINE

Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms

(2009) Ahmed Hasbi et al.   CURRENT OPINION IN PHARMACOLOGY

TAT-based drug delivery system – new directions in protein delivery for new hopes?

(2009) Matan Rapoport et al.   Expert Opinion on Drug Delivery

Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization

(2009) Sylwia Łukasiewicz et al.   FEBS Journal

Activation of calcium/calmodulin-dependent protein kinase IIα in the striatum by the heteromeric D1-D2 dopamine receptor complex

(2009) J. Ng et al.   NEUROSCIENCE

Heterodimerization of dopamine receptors: new insights into functional and therapeutic significance

(2009) Roberto Maggio et al.   PARKINSONISM & RELATED DISORDERS

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

(2009) Ahmed Hasbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of ECD/ETD to identify the site of electrostatic interaction in noncovalent complexes

(2008) Shelley N. Jackson et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY