The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction

Cathepsins D and L reduce the toxicity of advanced glycation end products

(2012) Stefanie Grimm et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5

(2012) Maria Buxadé et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Olfactomedin 4 Inhibits Cathepsin C-Mediated Protease Activities, Thereby Modulating Neutrophil Killing of Staphylococcus aureus and Escherichia coli in Mice

(2012) W. Liu et al.   JOURNAL OF IMMUNOLOGY

Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice

(2012) A. M. Avalos et al.   JOURNAL OF IMMUNOLOGY

Failure To Induce IFN-β Production during Staphylococcus aureus Infection Contributes to Pathogenicity

(2012) Amber Kaplan et al.   JOURNAL OF IMMUNOLOGY

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific functions of lysosomal proteases in endocytic and autophagic pathways

(2011) Sabrina Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phagosomal Degradation Increases TLR Access to Bacterial Ligands and Enhances Macrophage Sensitivity to Bacteria

(2011) A. J. Wolf et al.   JOURNAL OF IMMUNOLOGY

NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA

(2011) S. D. Deshmukh et al.   JOURNAL OF IMMUNOLOGY

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

(2010) Takahiro Shimada et al.   Cell Host & Microbe

Macrophages recognize streptococci through bacterial single-stranded RNA

(2010) Sachin D Deshmukh et al.   EMBO REPORTS

Cathepsin H Is an Additional Convertase of Pro-granzyme B

(2010) Michael E. D'Angelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysozymes in the animal kingdom

(2010) Lien Callewaert et al.   JOURNAL OF BIOSCIENCES

Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

(2010) Stephen P. Matthews et al.   JOURNAL OF IMMUNOLOGY

Phagocytosis and Phagosome Acidification Are Required for Pathogen Processing and MyD88-Dependent Responses to Staphylococcus aureus

(2010) W. K. E. Ip et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Human Integrin α3β1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments

(2010) Meghan L. Marre et al.   PLoS One

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice

(2010) L. Sevenich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes

(2010) J. M. Rybicka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

(2009) Vladimir R. Ramirez-Carrozzi et al.   CELL

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

(2009) Fernando E. Sepulveda et al.   IMMUNITY

Macrophage elastase kills bacteria within murine macrophages

(2009) A. McGarry Houghton et al.   NATURE

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

Molecular Pathogenesis of Staphylococcus aureus Infection

(2009) George Y Liu   PEDIATRIC RESEARCH

Intraphagosomal Measurement of the Magnitude and Duration of the Oxidative Burst

(2009) Brian C. VanderVen et al.   TRAFFIC

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome

(2008) W.K. Eddie Ip et al.   JOURNAL OF EXPERIMENTAL MEDICINE

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY