In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives

(2011) Z Janjetovic et al.   BRITISH JOURNAL OF CANCER

Production of 22-Hydroxy Metabolites of Vitamin D3 by Cytochrome P450scc (CYP11A1) and Analysis of Their Biological Activities on Skin Cells

(2011) R. C. Tuckey et al.   DRUG METABOLISM AND DISPOSITION

Vitamin D Analogs 17,20S(OH)2pD and 17,20R(OH)2pD Are Noncalcemic and Exhibit Antifibrotic Activity

(2011) Andrzej T. Slominski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitamin D metabolism and function in the skin

(2011) Daniel D. Bikle   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

(2011) N. Strushkevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

(2010) Andrzej T. Slominski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1 ,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity

(2010) E. K. Y. Tang et al.   DRUG METABOLISM AND DISPOSITION

Metabolism of substrates incorporated into phospholipid vesicles by mouse 25-hydroxyvitamin D3 1α-hydroxylase (CYP27B1)

(2010) Edith K.Y. Tang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D, disease and therapeutic opportunities

(2010) Lori A. Plum et al.   NATURE REVIEWS DRUG DISCOVERY

Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-Leukemia Effects, Having Low or Absent Calcemic Activity

(2010) Andrzej T. Slominski et al.   PLoS One

Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity

(2010) Wei Li et al.   STEROIDS

Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity

(2010) Michal A. Zmijewski et al.   STEROIDS

D-Hormone Derivatives for the Treatment of Osteoporosis: From Alfacalcidol to Eldecalcitol

(2009) Noboru Kubodera   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Sequential Metabolism of 7-Dehydrocholesterol to Steroidal 5,7-Dienes in Adrenal Glands and Its Biological Implication in the Skin

(2009) Andrzej T. Slominski et al.   PLoS One

20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes

(2009) Zorica Janjetovic et al.   PLoS One

Metabolism of Vitamin D2 to 17,20,24-Trihydroxyvitamin D2 by Cytochrome P450scc (CYP11A1)

(2008) M. N. Nguyen et al.   DRUG METABOLISM AND DISPOSITION

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

(2008) Robert C. Tuckey et al.   FEBS Journal

Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism

(2008) Daniel D. Bikle   JOURNAL OF INVESTIGATIVE DERMATOLOGY

20-Hydroxyvitamin D3, a Product of Vitamin D3 Hydroxylation by Cytochrome P450scc, Stimulates Keratinocyte Differentiation

(2008) Blazej Zbytek et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Metabolism of 1α-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1α,20-dihydroxyvitamin D3

(2008) Robert C. Tuckey et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3β, 17α, 20-triol and their bioactivity in melanoma cells

(2008) Michal A. Zmijewski et al.   STEROIDS