Journal
FASEB JOURNAL
Volume 24, Issue 7, Pages 2558-2566Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.09-153148
Keywords
cytokines; autoimmunity; immunosenescence
Categories
Funding
- Kenneth Rainin Foundation
- U.S. National Institutes of Health [HL31809]
Ask authors/readers for more resources
Human CD4(-)8(-) T cells are a minor subset quantitatively but potentially important in immunity because they are predominantly distributed at body surfaces, and their number and activities increase in autoimmune diseases and decrease with aging. Distinguishing characteristics of CD4(-)8(-) T cells are found to include a unique profile of cytokines, including Serpin E1, which is not generated by other T cells, MIF, and TGF-beta. At 2-5% of the total in mixtures with CD4 + CD8 T cells, CD4(-)8(-) T cells enhance the generation of IFN-gamma and IL-17 by up to 12- and 5-fold, respectively, without contributing either cytokine or affecting cytokine production by NK/NKT cells. CD4(-)8(-) T cell-derived MIF is their major enhancer and TGF beta their principal inhibitor of CD4 and CD8 T cell cytokine production. Decreases in CD4(-)8(-) T cell effects may diminish protective immunity in aging, whereas increases may augment the severity of autoimmune diseases.-Huang, M.-C., Patel, K., Taub, D. D., Longo, D. L., Goetzl, E.J. Human CD4(-)8(-) T cells are a distinctive immunoregulatory subset. FASEB J. 24, 2558-2566 (2010). www.fasebj.org
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available