Article
Oncology
Romy Mondschein, Damien Bolton, David Clouston, James Dowty, Liam Kavanagh, Declan Murphy, Prudence Scott, Renea A. Taylor, Heather Thorne
Summary: This study identified germline mutations associated with prostate cancer development and their correlation with prostate cancer characteristics. Mutations in ATM and CHEK2 genes were associated with aggressive prostate cancer. Further research is needed to confirm the prevalence and impact of these germline mutations in prostate cancer.
Article
Oncology
Yuko Minoura, Masato Takahashi, Hideki Maeda, Sayuri Kuwahara, Hanae Tachikawa, Mitsugu Yamamoto, Nobumoto Tomioka, Kenichi Watanabe, Akihiro Sakurai
Summary: When considering BRCA1/2 genetic testing, family history of prostate, pancreatic, and skin cancers should also be examined as HBOC-related cancers to provide testing for patients who would benefit from it.
Article
Urology & Nephrology
Mark N. Brook, Holly Ni Raghallaigh, Koveela Govindasami, Tokhir Dadaev, Reshma Rageevakumar, Diana Keating, Nafisa Hussain, Andrea Osborne, Artitaya Lophatananon, Kenneth R. Muir, Zsofia Kote-Jarai, Rosalind A. Eeles
Summary: A family history of prostate cancer is associated with an increased risk of developing the disease. This study examines how the number, degree, and age of relatives with prostate cancer are related to overall survival and prostate cancer-specific survival in prostate cancer patients.
Article
Public, Environmental & Occupational Health
Marie T. Kumerow, Juan L. Rodriguez, Shifan Dai, Katherine Kolor, Melissa Rotunno, Lucy A. Peipins
Summary: Collecting and evaluating family health history in a clinical setting can help discuss cancer risk, personalize cancer screening recommendations, and identify individuals with a potentially pathogenic variant who may benefit from genetic counseling and testing. A survey showed that around one-third of American adults reported a family history of cancer in a first-degree relative. This highlights the importance of using family history to guide discussions between healthcare providers and patients regarding cancer risk and screening options.
PREVENTIVE MEDICINE
(2022)
Article
Oncology
Hafdis T. Helgadottir, Jessada Thutkawkorapin, Anna Rohlin, Margareta Nordling, Kristina Lagerstedt-Robinson, Annika Lindblom
Summary: Identifying pathogenic variants remains challenging despite a strong history of CRC within families. Some rare high-risk mutations may cumulatively contribute to the occurrence of CRC in these families.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Health Care Sciences & Services
Florian Reichl, Daniela Muhr, Katharina Rebhan, Gero Kramer, Shahrokh F. Shariat, Christian F. Singer, Yen Y. Tan
Summary: This study evaluated cancer characteristics, family history, and outcomes of male BRCA1/2 mutation carriers, revealing that BRCA2 carriers were most likely to develop cancer and had worse prognosis. Breast cancer was the most common cancer in the study. Not all mutation carriers present with breast cancer or have a family history of cancer, justifying the need for genetic testing.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Surgery
Maria Daca-Alvarez, Marc Marti, Antonino Spinelli, Noel F. F. C. de Miranda, Claire Palles, Alfredo Vivas, Andrew Lachtford, Kevin Monahan, Marek Szczepkowski, Wieslaw Tarnowski, Silviu-Tiberiu Makkai-Popa, Rosario Vidal, Irene Lopez, Elena Hurtado, Fernando Jimenez, Marta Jimenez-Toscano, Edurne Alvaro, Gonzalo Sanz, Araceli Ballestero, Sirio Melone, Lorena Brandariz, Isabel Prieto, Damian Garcia-Olmo, Teresa Ocana, Rebeca Moreira, Lorena Moreno, Sabela Carballal, Leticia Moreira, Maria Pellise, Rogelio Gonzalez-Sarmiento, Andreana N. Holowatyj, Jose Perea, Francesc Balaguer
Summary: This study aimed to explore the impact of family history on preventing early-onset colorectal cancer, finding that the proportion of preventable cases varied based on different guidelines. Early colonoscopy could significantly decrease the incidence of familial early-onset colorectal cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Lizeth I. Tamayo, Fabian Perez, Angelica Perez, Miriam Hernandez, Alejandra Martinez, Xiaosong Huang, Valentina A. Zavala, Elad Ziv, Susan L. Neuhausen, Luis G. Carvajal-Carmona, Ysabel Duron, Laura Fejerman
Summary: Breast cancer is a major concern among Hispanic/Latina women in the U.S. Genetic counseling has been shown to be effective in informing women about their cancer risk, but Hispanic/Latina women are less likely to undergo genetic testing. In an effort to improve awareness and access to resources, a program was developed to educate monolingual Spanish-speaking individuals in California about hereditary breast cancer. The program successfully identified women in need of genetic counseling and highlighted the need for additional support in the Hispanic/Latina community.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Ghalib A. Jibara, Marlon Perera, Emily A. Vertosick, Daniel D. Sjoberg, Andrew Vickers, Peter T. Scardino, James A. Eastham, Vincent P. Laudone, Karim Touijer, Xin Lin, Maria Carlo, Behfar Ehdaie
Summary: This study explores the impact of family history on disease progression and adverse pathology in prostate cancer patients on active surveillance. The results suggest that a family history of prostate cancer is associated with an increased risk of disease progression, while a family history of other cancers or both is not. Family history is not associated with adverse pathology at surgery.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Adam C. Schneider, Thenappan Chandrasekar, Nicholas Bowler, Ryan Fogg, Joon Yau Leong, Andrew Gusev, Linda H. Rodgers, Shelley R. McCormick, Douglas M. Dahl, Jason A. Efstathiou, Michael L. Blute, Anthony L. Zietman, Chin-Lee Wu, Matthew R. Smith, Eliezer M. Van Allen, Adam S. Feldman, Keyan Salari
Summary: This study investigates the impact of a broader definition of family history, including genetic related malignancies, on active surveillance outcomes. It finds that a family history suggestive of a hereditary cancer syndrome is significantly associated with biopsy progression, but not adverse pathological features or biochemical recurrence. This suggests that family history may be an independent predictor of disease progression in active surveillance patients.
JOURNAL OF UROLOGY
(2023)
Article
Oncology
Erika N. N. Hanson, Emerson Delacroix, Sarah Austin, Grant Carr, Kelley M. M. Kidwell, Elizabeth Bacon, Lynette Hammond Gerido, Jennifer J. J. Griggs, Elena M. M. Stoffel, Ken Resnicow
Summary: This study examined patient barriers and motivators for cancer genetic testing. The results showed that female patients had more emotional, insurance, and family concerns before testing, but also had higher health benefits. Younger patients and those with BRCA-related cancer were more likely to have emotional and family concerns. Depression emerged as the most consistent factor influencing barriers to genetic testing.
Article
Medicine, General & Internal
Hyo Geun Choi, Woo Jin Bang, Jung Ki Jo, Cheol Young Oh, Myungsun Shim, Jin Seon Cho
Summary: This study found that a family history of prostate cancer in fathers posed a higher risk for patients compared to a family history in brothers. Additionally, age and hyperlipidemia were significant predictors of prostate cancer development.
Article
Oncology
Carielle Joy Rio, Taichi Goto, Chao-Pin Hsiao, Alexander L. R. Ross, Leorey N. Saligan
Summary: This study investigates the relationship between social/family wellbeing and sexual health in patients with prostate cancer. The findings suggest a moderate positive correlation between social/family wellbeing and sexual function, as well as a weak negative correlation between social/family wellbeing and sexual function distress. Depression and androgen deprivation therapy were found to significantly influence this relationship.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Clinical Neurology
Weicong Lu, Kody G. Kennedy, Alysha Sultan, Lisa M. Fiksenbaum, Mikaela K. Dimick, Simina Toma, Benjamin Goldstein
Summary: There were relatively few differences in clinical and neurostructural correlates related to family history of BD in youth with BD. Current findings suggest that family history of BD is not a strong contributor to the clinical or neuroimaging phenotypes in youth with BD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
QiongFei Zheng, Qinli Ying, ZhengJu Ren, Qin Zhang, DongLiang Lu, HongBai Wang, WuRan Wei
Summary: Family history of prostate cancer in first-degree relatives is associated with an increased risk of breast cancer, with consistent results in subgroup analysis. Compared with no family history of prostate cancer, history of prostate cancer in first-degree relatives is associated with a slight risk of ovarian cancer. Having a family history of prostate cancer among siblings may increase the risk of ovarian cancer by 17%, while no significant association was found between family history of prostate cancer among parents and the risk of ovarian cancer.
Article
Medicine, General & Internal
Theresia Pichler, Tamara Frank, Sabrina Maier, Ineke Batenhorst, Tanja Albawi-Daltrozzo, Nadia Harbeck, Hana Algul, Volker Heinemann, Kerstin Hermelink, Friederike Mumm, Andreas Dinkel
Summary: This study investigated the current needs and psychosocial burden of out-patients with cancer during the COVID-19 pandemic. The findings showed that over a third of the patients wanted more information about the effects of the coronavirus on their cancer and treatment, and some experienced changes in their current or planned treatment. COVID-19-related distress mainly included concerns about the healthcare system being overwhelmed and worries from family members. Most patients expressed willingness to get vaccinated against COVID-19, but some preferred to consult with an oncologist before making a final decision.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Correction
Medicine, General & Internal
Theresia Pichler, Tamara Frank, Sabrina Maier, Ineke Batenhorst, Tanja Albawi-Daltrozzo, Nadia Harbeck, Hana Algul, Volker Heinemann, Kerstin Hermelink, Friederike Mumm, Andreas Dinkel
Summary: This study investigated the needs and psychosocial burden of out-patients with cancer during the COVID-19 pandemic. The findings showed that more than a third of the patients desired more information about the effects of the coronavirus on their cancer and treatment, and there were concerns about possible overload of the healthcare system. The majority of patients were willing to receive the COVID-19 vaccine, and some expressed a desire for a consultation with an oncologist before making a decision.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Article
Oncology
Theresia Pichler, Peter Herschbach, Tamara Frank, Friederike Mumm, Andreas Dinkel
Summary: This paper provides a narrative overview of the barriers to the utilization of psycho-oncological care. It discusses individual barriers, including timing, patients' perception of psychological distress, and availability of personal/social resources, as well as barriers related to information and attitudes towards psycho-oncology. Structural barriers, such as funding and documentation of patients' needs for psycho-oncological care, are also addressed. The results highlight the importance of addressing individual concerns with accessible information and the need for interdisciplinary cooperation and digital solutions to reduce structural barriers.
Article
Medicine, General & Internal
Alexander Baeuerle, Peter Martus, Yesim Erim, Caterina Schug, Jana Heinen, Julia Barbara Krakowczyk, Jasmin Steinbach, Mirjam Damerau, Wolfgang Bethge, Andreas Dinkel, Sebastian Dries, Anja Mehnert-Theuerkauf, Anja Neumann, Dirk Schadendorf, Mitra Tewes, Joerg Wiltink, Alexander Wuensch, Stephan Zipfel, Johanna Graf, Martin Teufel
Summary: This study aims to assess the efficacy of a manualised e-mental health intervention for reducing psychological distress in cancer patients and compare it with treatment as usual. The study includes two parallel arms with 600 cancer patients in each group.
Article
Psychiatry
Almut Zeeck, Svenja Taubner, Thorsten C. Gablonski, Inga Lau, Stephan Zipfel, Wolfgang Herzog, Beate Wild, Hans-Christoph Friederich, Gaby Resmark, Katrin Giel, Martin Teufel, Markus Burgmer, Andreas Dinkel, Stephan Herpertz, Bernd Loewe, Sefik Tagay, Joern von Wietersheim, Martina De Zwaan, Max Zettl, Alexander F. Meier, Armin Hartmann
Summary: The results suggest that patients with anorexia nervosa have a low capacity for mentalizing during therapy sessions, which is partly dependent on the degree of starvation. The study also found that an increase in mentalizing during sessions is associated with better treatment outcomes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Matthias Jahnen, Leopold Zeng, Martina Kron, Valentin H. Meissner, Alexander Korte, Stefan Schiele, Helga Schulwitz, Andreas Dinkel, Juergen E. Gschwend, Kathleen Herkommer
Summary: The study found that a majority of male medical students consume pornography frequently, while only 7.3% of female students do so. It also revealed that students who were inspired by pornography and those who have had experiences such as anal intercourse or threesomes tend to consume pornography more frequently.
Article
Oncology
Valentin H. Meissner, Cornelia Peter, Donna P. Ankerst, Stefan Schiele, Juergen E. Gschwend, Kathleen Herkommer, Andreas Dinkel
Summary: This longitudinal study investigates the course and predictors of prostate cancer-related anxiety in long-term survivors treated by radical prostatectomy. The study found that prostate cancer-related anxiety remains stable over 5 years, and factors such as initial anxiety levels, biochemical recurrence, and psychological well-being predict future anxiety.
Article
Urology & Nephrology
Valentin H. Meissner, Barbara W. Simson, Andreas Dinkel, Stefan Schiele, Donna P. Ankerst, Lukas Lunger, Juergen E. Gschwend, Kathleen Herkommer
Summary: This study investigates the prevalence, course, and predictors of decision regret in long-term prostate cancer survivors treated by radical prostatectomy. The findings suggest that decision regret increases over time and is associated with localized prostate cancer, previous decision regret, higher depression scores, and less shared decision-making.
Article
Psychology, Clinical
Alexander Ferdinand Meier, Almut Zeeck, Svenja Taubner, Thorsten Gablonski, Inga Lau, Romi Preiter, Hannes Glaeser, Stephan Zipfel, Wolfgang Herzog, Beate Wild, Hans-Christoph Friederich, Gaby Resmark, Katrin Giel, Martin Teufel, Markus Burgmer, Andreas Dinkel, Stephan Herpertz, Bernd Loewe, Sefik Tagay, Joern von Wietersheim, Martina De Zwaan, Armin Hartmann
Summary: This study aimed to explore the use of mentalization-enhancing interventions (MEIs) in psychotherapeutic treatments for patients with anorexia nervosa and their association with patients' capacity to mentalize in sessions. The results showed a moderate correlation between the amount of MEIs used and patients' in-session reflective functioning, but no relation to change in BMI or eating disorder symptoms.
PSYCHOTHERAPY RESEARCH
(2023)
Article
Oncology
Matthias Jahnen, Patrick Bayer, Valentin H. Meissner, Stefan Schiele, Helga Schulwitz, Juergen E. Gschwend, Kathleen Herkommer, Andreas Dinkel
Summary: This study investigated the extent of benefit finding and associated factors in prostate cancer survivors. The results showed that many patients experience positive life-changes soon after diagnosis and this feeling remains relatively stable over time. The perception of disease severity, cancer-related distress, and quality of life were found to be important factors influencing benefit finding.
Article
Psychology, Multidisciplinary
Tamara Frank, Theresia Pichler, Sabrina Maier, Ineke Batenhorst, Tanja Abawi, Nadia Harbeck, Hana Alguel, Volker Heinemann, Kerstin Hermelink, Friederike Mumm, Andreas Dinkel
Summary: This study aimed to investigate the impact of pandemic-related stressors on the psychological well-being of oncological patients. The results showed that satisfaction with information was negatively associated with psychological symptoms, while fear of disease deterioration was related to distress and depressive symptoms. The study suggests that physical well-being has a stronger influence on patients' psychological well-being, and satisfaction with information is an important determinant of anxiety.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Timo Brockmeyer, Marieke Titzmann, Stephan Zipfel, Beate Wild, Gaby Resmark, Martin Teufel, Katrin Giel, Martina de Zwaan, Andreas Dinkel, Stephan Herpertz, Markus Burgmer, Bernd Loewe, Sefik Tagay, Eva Rothermund, Almut Zeeck, Wolfgang Herzog, Hans-Christoph Friederich
Summary: This study investigated the role of general change mechanisms in body-weight related sudden gains (SGs) in cognitive-behavioral therapy (CBT) and focal psychodynamic therapy (FPT) for anorexia nervosa. The findings suggest that clarification and mastery contribute to SGs, but therapeutic relationship does not.
BEHAVIOUR RESEARCH AND THERAPY
(2023)
Meeting Abstract
Urology & Nephrology
Kathleen Herkommer, Lukas Lunger, Valentin Meissner, Benedikt Kopp, Andreas Dinkel, Stefan Schiele, Donna Ankerst, Juergen Gschwend
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Kathleen Herkommer, Valentin Meissner, Lukas Lunger, Kolja Imhof, Matthias Jahnen, Donna Ankerst, Andreas Dinkel, Stefan Schiele, Juergen Gschwend
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Matthias Jahnen, Leopold Zeng, Martina Kron, Valentin H. Meissner, Alexander Korte, Stefan Schiele, Helga Schulwitz, Andreas Dinkel, Juergen Gschwend, Kathleen Herkommer
JOURNAL OF SEXUAL MEDICINE
(2022)