Review
Oncology
Giovanni Corso, Federica Corso, Federica Bellerba, Patricia Carneiro, Susana Seixas, Antonio Cioffi, Carlo La Vecchia, Francesca Magnoni, Bernardo Bonanni, Paolo Veronesi, Sara Gandini, Joana Figueiredo
Summary: E-cadherin germline mutations, particularly CDH1 gene mutations, are associated with hereditary diffuse gastric cancer syndrome. The frequency of CDH1 mutations varies across different geographical areas, with a higher incidence in low-prevalence countries. The type and relative frequency of CDH1 mutations also differ between study groups and regions, with missense variants more common in high-incidence areas. Identifying individuals with clinically significant CDH1 mutations is crucial for effective genetic screening and patient management in gastric cancer.
Article
Oncology
Zhiwen Pan, Zhixuan Fu, Cong Luo, Yejiang Bao, Mingli Wang, Wenming Cao, Xiaohong Xu
Summary: The frequency of CDH1 germline mutations in Chinese patients with HDGC is 7.4%, with new variants identified as N405Y and W409X. Among the 21 patients, up to 28.6% of CDH1 mutations were c.1775G>C (E551Q).
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Huichen Zhao, Huihui Hu, Beibei Chen, Weifeng Xu, Jing Zhao, Chen Huang, Yishu Xing, Huifang Lv, Caiyun Nie, Jianzheng Wang, Yunduan He, Sai-Qi Wang, Xiao-Bing Chen
Summary: Gastric cancer ranks fifth in global cancer incidence and third in cancer mortality. E-cadherin is crucial in tumorigenesis, tumor progression, metastasis, with soluble E-cadherin playing a role in promoting invasion and metastasis in gastric cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Genetics & Heredity
Mathis Lepage, Nancy Uhrhammer, Maud Privat, Flora Ponelle-Chachuat, Myriam Kossai, Julien Scanzi, Zangbewende Guy Ouedraogo, Mathilde Gay-Bellile, Yannick Bidet, Mathias Cavaille
Summary: Germline pathogenic variants in E-cadherin (CDH1) are associated with a high risk of developing lobular breast cancer and diffuse gastric cancer (DGC). The cumulative risk of DGC in CDH1 carriers has been reassessed recently, and the risk varies depending on the presence and number of gastric cancers in the family. The management of CDH1 carriers, particularly those with incidental findings, poses challenges for both patients and providers. This study reports on the management of the risk of DGC in a family with CDH1 carriers, as well as the incidental finding of a rare aggressive cancer in a CDH1 carrier.
Review
Surgery
Lauren A. Gamble, Theo Heller, Jeremy L. Davis
Summary: Inherited variants in the CDH1 tumor suppressor gene are associated with increased risk of gastric and breast cancers. Current management strategies for the hereditary diffuse gastric cancer syndrome include prophylactic surgery and enhanced cancer surveillance. Further research is needed to understand the pathogenesis of early-stage gastric cancers and develop effective treatment and prevention strategies for this population.
Review
Oncology
Chi Zhang, Ran Liu, Wei-Han Zhang, Xin-Zu Chen, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Zhi-Xin Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: The study found that patients with signet ring cell gastric cancer are typically younger and more commonly female compared to those with non-signet ring cell gastric cancer. For early stage signet ring cell gastric cancer patients, they have a lower lymph nodes metastasis rate and comparable prognosis with non-signet ring cell cancers; however, in advanced tumor stage, signet ring cell gastric cancer has a significantly worse prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Matthew G. K. Benesch, Stuart R. Bursey, Andrew C. O'Connell, Morag G. Ryan, Carrie L. Howard, Cecily C. Stockley, Alexander Mathieson
Summary: Despite systematic biopsy protocols, many early cancers might be missed on endoscopy. Therefore, patients with hereditary gastric cancer should not rely on endoscopy to delay surgery and may have secondary adenocarcinoma risks. To confirm the risks, collaborative patient outcome data banking is needed.
Article
Oncology
Mitsuhiro Nikaido, Nobuyuki Kakiuchi, Shin'ichi Miyamoto, Tomonori Hirano, Yasuhide Takeuchi, Taro Funakoshi, Akira Yokoyama, Tatsuki Ogasawara, Yoshihiro Yamamoto, Atsushi Yamada, Takeshi Setoyama, Takahiro Shimizu, Yukari Kato, Suguru Uose, Takaki Sakurai, Sachiko Minamiguchi, Kazutaka Obama, Yoshiharu Sakai, Manabu Muto, Tsutomu Chiba, Seishi Ogawa, Hiroshi Seno
Summary: The study found that CDH1 somatic mutation is a driver mutation for Hp-uninfected intramucosal DGC, while TP53 mutation is more common in advanced DGC. Intramucosal DGCs are mainly pure signet ring cell carcinoma with a lower likelihood of developing into advanced DGCs.
Article
Oncology
Futoshi Muranaka, Emiko Kise, Shigeo Tokumaru, Masato Kitazawa, Yusuke Miyagawa, Tomoaki Suga, Takeshi Uehara, Mai Iwaya, Shota Kobayashi, Midori Sato, Daisuke Gomi, Hidetaka Yamada, Haruhiko Sugimura, Tomoki Kosho, Yuji Soejima, Tomonobu Koizumi
Summary: This study reports the clinical courses of three cases with hereditary diffuse gastric cancer in a Japanese family. One patient had advanced and metastatic gastric cancer and was found to have a known heterozygous frameshift variant in the CDH1 gene. Genetic testing for relatives revealed three positive cases, all of whom underwent total prophylactic gastrectomy after abnormal findings in endoscopy.
Review
Biochemistry & Molecular Biology
Jooske L. Monster, Lars J. S. Kemp, Martijn Gloerich, Rachel S. van der Post
Summary: Gastric cancer is the fourth leading cause of cancer-related deaths worldwide, and patients with diffuse-type gastric cancer have a poor prognosis with limited effectiveness of conventional chemotherapies. However, recent advancements in mouse and organoid models, as well as multi-omic analyses, are shedding light on the mechanisms responsible for DGC initiation and progression, offering potential opportunities for targeted therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Medicine, Research & Experimental
Nastazja Dagny Pilonis, Marc Tischkowitz, Rebecca C. Fitzgerald, Massimiliano di Pietro
Summary: Hereditary diffuse gastric cancer (HDGC) is a rare cancer syndrome associated with significant risks of gastric and lobular breast cancer, often presenting late in clinical settings. While most cases can be traced back to germline variants in the CDH1 gene, some families with clustering of DGC do not have a clear genetic cause. This review focuses on discussing key elements for assessing inherited DGC susceptibility, providing practical recommendations for surveillance and treatment of at-risk individuals and early-stage patients.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Oncology
Yangkun Wang, Yingying Li, Bin Wang, Dongmei Ran, Chaoya Zhu, Ping Li, Bo Jiang, Sunan Wang
Summary: This study investigated the early onset, development, and histological features of gastric signet-ring cell carcinoma (SRCC). The results showed that gastric mucosa infection, especially by Helicobacter pylori, can cause massive cell proliferation and transformation in specific areas of the stomach. SRCC grows infiltratively and can differentiate into various types of adenocarcinoma with signet-ring cell differentiation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nastazja D. Pilonis, Maria O'Donovan, Susan Richardson, Rebecca C. Fitzgerald, Massimiliano di Pietro
Summary: This study aimed to identify diagnostic criteria for early signet-ring cell carcinoma (SRCC) in patients with hereditary diffuse gastric cancer (HDGC) using probe-based confocal laser endomicroscopy (pCLE). Four pCLE patterns associated with SRCC histologic features were identified and a panel comprising three criteria (A, B, and C) showed high diagnostic accuracy for SRCC.
BMC GASTROENTEROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lidia-Sabina Cosma, Sophie Schlosser, Hauke C. Tews, Martina Mueller, Arne Kandulski
Summary: This article presents an overview of the genetic characteristics and current treatment approaches of hereditary diffuse gastric cancer (HDGC). It highlights the importance of the CTNNA1 gene, among others, in relation to this disease, and emphasizes the need for risk management in diagnosing patients through genetic testing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Luigina Graziosi, Elisabetta Marino, Nicola Natalizi, Annibale Donini
Summary: This study investigates the clinical pathological characteristics and survival prognostic significance of signet ring cell components in patients affected by gastric cancer. The incidence of signet ring cell carcinoma is increasing over time. The prognosis of signet ring cell carcinoma is better in early gastric cancer, but recurrence occurs more frequently in these patients. Factors such as preoperative serum albumin level, surgical resection, lymphadenectomy level, and pathological stage are independent factors affecting overall survival. Radical surgical procedures and adequate lymphadenectomy should be advocated to improve patient survival.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Yuri Kim, Bokyung Ahn, Kee Don Choi, Beom-Su Kim, Jeong-Hwan Yook, Gin Hyug Lee, Seung-Mo Hong, Jeong Hoon Lee
Summary: This study systematically evaluated the clinical and pathologic characteristics of gastric neuroendocrine tumors (NETs) based on the 2019 WHO classification. The results showed that grade 2 and grade 3 gastric NETs are associated with larger size, deeper invasion, and extragastric recurrence, requiring active treatment.
Article
Gastroenterology & Hepatology
Jin Hee Noh, Do Hoon Kim, Kee Wook Jung, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study aimed to report our experience with diverticular peroral endoscopic myotomy (D-POEM) and investigate the usefulness of endoscopic functional luminal imaging probe (EndoFLIP) in determining the need for cardiomyotomy with septotomy for symptomatic epiphrenic diverticulum. The results showed that EndoFLIP may help decide whether to perform combined cardiomyotomy and septotomy for the treatment of an epiphrenic diverticulum. Further large-scale studies are needed to confirm these results.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Joon Sung Kim, Weonjin Ko, Jun-Won Chung, Tae Ho Kim
Summary: This study compared the efficacy and safety profiles of tegoprazan-based quadruple therapy and lansoprazole-based quadruple therapy for Helicobacter pylori eradication. The results showed that tegoprazan-based quadruple therapy had higher eradication rates than lansoprazole-based quadruple therapy in intention-to-treat, modified intention-to-treat, and per-protocol analysis. There was no significant difference in the rate of adverse events between the two groups. Therefore, tegoprazan might be a substitute for proton pump inhibitors in H. pylori eradication regimens.
Article
Multidisciplinary Sciences
So Hyun Park, Young Jae Kim, Kwang Gi Kim, Jun-Won Chung, Hyun Cheol Kim, In Young Choi, Myung-Won You, Gi Pyo Lee, Jung Han Hwang
Summary: This study aimed to develop a CNN using the EfficientNet algorithm for automated classification of acute appendicitis, acute diverticulitis, and normal appendix on CT images, and evaluate its diagnostic performance. The results showed that the RGB serial image method had slightly higher sensitivity, accuracy, and specificity for classifying normal appendix and acute diverticulitis compared to the single image method. Additionally, the mean areas under the ROC curve were significantly higher with the RGB serial image method for all three conditions. Therefore, the model accurately distinguished these conditions on CT images, particularly when using the RGB serial image method.
Article
Surgery
Seokin Kang, Jeong Hoon Lee, Yuri Kim, Kwangbeom Park, Hee Kyong Na, Ji Yong Ahn, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study aimed to compare the outcomes of endoscopic submucosal dissection (ESD) and surgery in elderly patients with early gastric cancer (EGC) that is not indicated for endoscopic resection (ER). The results showed that ESD may be an alternative option for elderly patients aged >= 75 years who are not suitable for ER.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Medical Laboratory Technology
Sollip Kim
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Eun-Jung Cho, Tae-Dong Jeong, Sollip Kim, Hyung-Doo Park, Yeo-Min Yun, Sail Chun, Won-Ki Min
Summary: In order to ensure valid results in medical big data research, it is important to have high-quality laboratory input. This study aimed to establish a strategy for evaluating the quality of laboratory results suitable for big data research using KEQAS data. The acceptance rate and bias of different test items were analyzed, showing significant differences based on the quality grade for each criterion.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Jeonghyun Chang, Jinsook Lim, Jae-Woo Chung, Yong-Hak Sohn, Min Joong Jang, Sollip Kim
Summary: Pre-analytical quality management is inadequate in many primary care clinics in Korea, leading to potential impacts on laboratory test results. Implementation of a mandatory management system is necessary to ensure proper pre-analytical quality management in primary care clinics.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Hannah Lee, Hyo Sang Hwang, Jun-Won Chung, Kyeong Ah Kim, Seon Tae Kim
Summary: This study developed a liquid-type medium, Helicotest (R), to enable faster detection of Helicobacter pylori. Compared to other commercial kits, Helicotest (R) showed the fastest reaction time of 5 minutes for detecting H. pylori. Therefore, it is expected to facilitate faster diagnosis in clinical practice.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Surgery
Yuri Kim, Seokin Kang, Ji Yong Ahn, Hwoon-Yong Jung, Gin Hyug Lee, Ho June Song, Kee Don Choi, Do Hoon Kim, Kee Wook Jung, Jeong Hoon Lee, Hee Kyong Na
Summary: This study aimed to investigate the likelihood of recurrence of gastric hyperplastic polyps (GHPs) following endoscopic resection and the need for long-term follow-up. The study found that the incidence of GHP recurrence increased as the follow-up period increased, especially in patients with large-sized, multiple, or characterized by surface exudates/lobulations.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Younghee Choe, Byung-Wook Kim, Tae Ho Kim, Jun-Won Chung, Jongwon Kim, Soo-Young Na, Joon Sung Kim
Summary: This study aimed to determine the optimal interval for surveillance gastroscopy after endoscopic resection for gastric neoplasia and investigate the risk factors for metachronous gastric neoplasia. A retrospective review of medical records identified 677 patients who underwent endoscopic resection, and it was found that severe atrophic gastritis was an independent risk factor for metachronous gastric adenocarcinoma.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Letter
Medical Laboratory Technology
Seunghoo Lee, Sangpil Yoon, Hyun-Ki Kim, Sollip Kim, Woochang Lee, Sail Chun, Won-Ki Min
ANNALS OF LABORATORY MEDICINE
(2023)
Review
Oncology
JunHo Lee, Hanna Lee, Jun-won Chung
Summary: Stomach cancer has a high mortality rate worldwide, and AI technology is being developed to assist in early detection and accurate treatment. The deep learning algorithm can accurately detect gastric lesions and predict morphological characteristics, helping surgeons select the correct treatment method.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Medical Laboratory Technology
Seunghoo Lee, Joonsang Yu, Chan-Ik Cho, Eun-Jung Cho, Tae-Dong Jeong, Sollip Kim, Woochang Lee, Sail Chun, Won-Ki Min
Summary: This study evaluates the performance of a collaboration between academia and the government in standardizing laboratory medicine in Korea, specifically in the field of creatinine testing. The results show improvements in acceptance rates and bias levels over the eight-year period, indicating the positive impact of the collaboration.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Sollip Kim, Eun-Jung Cho, Tae-Dong Jeong, Hyung-Doo Park, Yeo-Min Yun, Kyunghoon Lee, Yong-Wha Lee, Sail Chun, Won-Ki Min
ANNALS OF LABORATORY MEDICINE
(2023)