Article
Genetics & Heredity
C. Bethan Powell, Cecile Laurent, Christine Garcia, Elizabeth Hoodfar, Audrey Karlea, Christine Kobelka, Jaimie Lee, Janise Roh, Lawrence H. Kushi
Summary: This study investigated the impact of disparities and other factors on referral to genetic counseling and testing for hereditary breast and ovarian cancer syndrome (HBOC) within a large healthcare system. Factors such as younger age, family history, and chemotherapy were found to be associated with referral, while higher comorbidity score and prior cancer were associated with non-referral. Race was only a significant factor for breast cancer, with fewer Asians referred compared to Whites. Despite differences in specific cancers, health disparities in genetic referral for HBOC cancers were mitigated within a comprehensive integrated healthcare system.
Article
Biochemistry & Molecular Biology
Mar Infante, Monica Arranz-Ledo, Enrique Lastra, Luis Enrique Abella, Raquel Ferreira, Marta Orozco, Lara Hernandez, Noemi Martinez, Mercedes Duran
Summary: The probability of carrying two pathogenic variants in dominant cancer-predisposing genes for hereditary breast and ovarian cancer and lynch syndromes in the same patient is uncommon. However, four cases of patients carrying different pathogenic variants in breast, ovarian, or colorectal cancer have been identified. The ages at diagnosis and severity of disease were similar to those in single gene carriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
D. C. Greenberg, D. Kamara, Z. Tatsugawa, M. Mendoza, E. Pineda, C. H. Holschneider, M. Zakhour
Summary: This study assessed the quality of patient education videos from four major genetic testing companies and found variability in content, with the videos performing well in explaining DNA basics, cancer development, and hereditary cancer predisposition, but poorly in addressing potential disadvantages of genetic testing, medical terms, and different testing options.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Anna Ofverholm, Therese Toerngren, Anna Rosen, Brita Arver, Zakaria Einbeigi, Karin Haraldsson, Anne Kinhult Stahlbom, Ekaterina Kuchinskaya, Annika Lindblom, Beatrice Melin, Ylva Paulsson-Karlsson, Marie Stenmark-Askmalm, Emma Tham, Anna von Wachenfeldt, Anders Kvist, Ake Borg, Hans Ehrencrona
Summary: This study assessed the genetic variation in a large cohort of women with suspected HBOC and found that extending clinical genetic screening from BRCA1 and BRCA2 to 13 established cancer predisposition genes almost doubles the diagnostic yield. This has implications for genetic counseling and clinical guidelines.
Review
Oncology
Jenny Lin, Ravi N. Sharaf, Rachel Saganty, Danyal Ahsan, Julia Feit, Andrea Khoury, Hannah Bergeron, Eloise Chapman-Davis, Evelyn Cantillo, Kevin Holcomb, Stephanie V. Blank, Ying Liu, Charlene Thomas, Paul J. Christos, Drew N. Wright, Steven Lipkin, Kenneth Offit, Melissa K. Frey
Summary: This study evaluates the literature on genetic assessment for women with ovarian cancer and finds that rates of genetic testing remain below the goal of universal testing. Interventions such as mainstreaming can improve testing uptake, and strategies to improve utilization of genetic services should consider existing disparities in race and insurance status.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Benedikt Zang, Malina Helms, Laura Besch, Nanette Kalmbach, Stephanie Stegen, Jens-Uwe Blohmer, Dorothee Speiser
Summary: Genetic counseling and analysis play a crucial role in the prevention and treatment of hereditary breast and ovarian cancer. The rate of pathogenic variants detected is associated with family history, breast cancer subtype, and age at diagnosis, and can have a significant impact. Therefore, a standardized process of identification, genetic counseling, and genetic analysis is necessary.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Health Care Sciences & Services
Ute Felbor, Robin Buelow, Rita K. Schmutzler, Matthias Rath
Summary: The German Consortium Hereditary Breast and Ovarian Cancer (GC-HBOC) consists of 23 academic centers that aim to provide high-quality regional care for affected individuals and at-risk family members. Our experience in the North Eastern part of Germany demonstrates the feasibility of establishing a high-risk breast and ovarian cancer service even in a sparsely populated region.
Article
Public, Environmental & Occupational Health
Friedrich Kuehn, Maria Margarete Karsten, Friederike Kendel, Markus A. Feufel, Dorothee Speiser
Summary: The training course aimed to strengthen cross-sectoral care by disseminating specialized knowledge about hereditary breast and ovarian cancer in underserved areas. Results showed an increase in certainty regarding inclusion criteria for genetic counseling, but participants still faced difficulties in interpreting and differentiating risks.
PATIENT EDUCATION AND COUNSELING
(2021)
Article
Public, Environmental & Occupational Health
Elen Siglen, Hildegunn Hoberg Vetti, Aslaug Beathe Forberg Lunde, Thomas Akselberg Hatlebrekke, Nina Stromsvik, Anniken Hamang, Sigrid Tronsli Hovland, Jill Walker Rettberg, Vidar M. Steen, Cathrine Bjorvatn
Summary: This study aimed to develop a pilot version of an app called Rosa that utilizes chatbot technology to engage in digital conversations with breast or ovarian cancer patients about genetic BRCA testing. The research employed a commercial chatbot platform and participatory methodology, collaborating with a team of patient representatives, IT engineers, genetic counselors, and clinical geneticists nationwide. An iterative approach was taken, allowing for extensive user testing and formal usability testing during the development process.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Oncology
Alexandra Wehbe, Mark Manning, Hadeel Assad, Kristen S. Purrington, Michael S. Simon
Summary: This study examined racial differences in referral and uptake of genetic counseling among women with breast cancer. The findings showed no racial differences in referral or appointment completion in a clinic-based population of women with breast cancer. The study suggests the need for further interventions to increase referral and appointment completion for eligible women.
Article
Public, Environmental & Occupational Health
Sara Gomez-Trillos, Kristi D. Graves, Katie Fiallos, Marc D. Schwartz, Beth N. Peshkin, Heidi Hamilton, Vanessa B. Sheppard, Susan T. Vadaparampil, Claudia Campos, Ana Paula Cupertino, Maria C. Alzamora, Filipa Lynce, Alejandra Hurtado-de-Mendoza
Summary: This article describes the process of adapting a telephone genetic counseling protocol and visual aid booklet for Spanish-preferring Latina breast cancer survivors at increased risk for hereditary breast and ovarian cancer (HBOC). Culturally adapting interventions can improve health outcomes in historically marginalized populations and promote equity.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ava Kwong, Cecilia Y. S. Ho, Vivian Y. Shin, Chun Hang Au, Tsun Leung Chan, Edmond S. K. Ma
Summary: This passage describes a 48-year-old female patient with biallelic pathogenic mutations of the BRCA1 gene, diagnosed with ovarian and breast cancer, and with a strong family history of breast and gynecological cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Arian Mansur, Fang Zhang, Christine Y. Lu
Summary: Genetic testing and counseling play important roles in patient care, but access to these services is influenced by health insurance coverage. Limited research has been conducted on the association between health insurance and the uptake of genetic testing and counseling. This study found that women with health insurance, particularly military and private insurance, were more likely to undergo genetic testing and counseling for breast/ovarian cancer risk.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Celia Villafane-Bernier, Julie Lapointe, Camille Raiche, Sophie Lauzier, Jocelyne Chiquette, Karine Bouchard, Sylvie Pelletier, Arian Omeranovic, Josee Rheaume, Claire Brousseau, Johanne Hebert, Michel Dorval, Hermann Nabi
Summary: Through cultural adaptation and validation, a French version of the GCSS has been developed, which is clearly understood by patients and has psychometric properties in line with the original English version.
Review
Oncology
Fernando Augusto Batista Campos, Etienne Rouleau, Giovana Tardin Torrezan, Dirce Maria Carraro, Jose Claudio Casali da Rocha, Higor Kassouf Mantovani, Leonardo Roberto da Silva, Cynthia Aparecida Bueno de Toledo Osorio, Solange Moraes Sanches, Sandrine M. Caputo, Elizabeth Santana dos Santos
Summary: Male breast cancer is a rare disease, with distinct genetic background compared to female breast cancer. Common genetic and epigenetic features of female breast cancer are not shared with male breast cancer. Inherited germline variants likely play a significant role in the tumorigenesis of male breast cancer.
Article
Oncology
Jean A. McDougall, Matthew P. Banegas, Charles L. Wiggins, Vi K. Chiu, Ashwani Rajput, Anita Y. Kinney
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2018)
Article
Oncology
Sonam Puri, Kelly A. Hyland, Kristine Crowe Weiss, Gillian C. Bell, Jhanelle E. Gray, Richard Kim, Hui-Yi Lin, Aasha I. Hoogland, Brian D. Gonzalez, Ashley M. Nelson, Anita Y. Kinney, Stacy M. Fischer, Daneng Li, Paul B. Jacobsen, Howard L. McLeod, Heather S. L. Jim
SUPPORTIVE CARE IN CANCER
(2018)
Article
Medicine, Research & Experimental
Anita Y. Kinney, Rachel Howell, Rachel Ruckman, Jean A. McDougall, Tawny W. Boyce, Belinda Vicuna, Ji-Hyun Lee, Dolores D. Guest, Randi Rycroft, Patricia A. Valverde, Kristina M. Gallegos, Angela Meisner, Charles L. Wiggins, Antoinette Stroup, Lisa E. Paddock, Scott T. Walters
CONTEMPORARY CLINICAL TRIALS
(2018)
Article
Public, Environmental & Occupational Health
Morgan M. Millar, Anita Y. Kinney, Nicola J. Camp, Lisa A. Cannon-Albright, Mia Hashibe, David F. Penson, Anne C. Kirchhoff, Deborah W. Neklason, Alicia W. Gilsenan, Gretchen S. Dieck, Antoinette M. Stroup, Sandra L. Edwards, Carrie Bateman, Marjorie E. Carter, Carol Sweeney
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Oncology
Jean A. McDougall, Cindy K. Blair, Charles L. Wiggins, Michael B. Goodwin, Vi K. Chiu, Ashwani Rajput, Anita Y. Kinney
JOURNAL OF CANCER SURVIVORSHIP
(2019)
Article
Obstetrics & Gynecology
Nelangi M. Pinto, Kevin A. Henry, Guo Wei, Xiaoming Sheng, Tom Green, Michael D. Puchalski, Janice L. B. Byrne, Anita Y. Kinney
FETAL DIAGNOSIS AND THERAPY
(2020)
Article
Oncology
Cindy K. Blair, Jean A. McDougall, Vi K. Chiu, Charles L. Wiggins, Ashwani Rajput, Elizabeth M. Harding, Anita Y. Kinney
CANCER CAUSES & CONTROL
(2019)
Article
Health Care Sciences & Services
Kerstin Kalke, Tamar Ginossar, Joshua M. Bentley, Hannah Carver, Sayyed Fawad Ali Shah, Anita Y. Kinney
JMIR MHEALTH AND UHEALTH
(2020)
Article
Oncology
Jaya M. Satagopan, Antoinette Stroup, Anita Y. Kinney, Tina Dharamdasani, Shridar Ganesan, Elisa V. Bandera
Summary: Breast cancer incidence rates among Asian Indian and Pakistani American women are lower than non-Hispanic white women, but they are diagnosed at a younger age and tend to have more aggressive tumor characteristics. Further research is needed to understand and address the unique characteristics of breast cancer in Asian Indian and Pakistani women.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
W. Iris Zhi, Danielle Gentile, Maggie Diller, Anita Kinney, Ting Bao, Viraj Master, Xin Shelley Wang
Summary: Pain is a primary concern for cancer patients and survivors, with integrative interventions like acupuncture, massage, and music therapy being effective nonpharmacologic approaches. Patient-reported outcomes (PROs) are useful for evaluating pain intensity, associated symptom burden, and quality of life, with well-validated PROs improving patient satisfaction and symptom control. Well-standardized pain PROs are essential for high-quality integrative oncology research and effective intervention utilization.
Article
Health Care Sciences & Services
Cindy K. Blair, Elizabeth Harding, Carla Herman, Tawny Boyce, Wendy Demark-Wahnefried, Sally Davis, Anita Y. Kinney, Vernon S. Pankratz
JMIR RESEARCH PROTOCOLS
(2020)
Article
Psychology, Multidisciplinary
C. Graham Ford, Kevin E. Vowles, Bruce W. Smith, Anita Y. Kinney
ANNALS OF BEHAVIORAL MEDICINE
(2020)
Article
Medicine, Research & Experimental
Anita Y. Kinney, Cindy K. Blair, Dolores D. Guest, Julianne K. Ani, Elizabeth M. Harding, Fabiano Amorim, Tawny Boyce, Joseph Rodman, C. Graham Ford, Matthew Schwartz, Larissa Rosenberg, Olivia Foran, Jerry Gardner, Yong Lin, Wadih Arap, Michael R. Irwin
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2019)
Article
Genetics & Heredity
Deborah O. Himes, Sarah H. Davis, Jane H. Lassetter, Neil E. Peterson, Margaret F. Clayton, Wendy C. Birmingham, Anita Y. Kinney
JOURNAL OF COMMUNITY GENETICS
(2019)
Article
Genetics & Heredity
Belinda Vicuna, Harold D. Delaney, Kristina G. Flores, Lori Ballinger, Melanie Royce, Zoneddy Dayao, Tuya Pal, Anita Y. Kinney
JOURNAL OF COMMUNITY GENETICS
(2018)