Article
Medicine, General & Internal
Weiwei Lu, Rui Ning, Kai Diao, Yang Ding, Ruru Chen, Lei Zhou, Yan Lian, Colm McAlinden, Francis W. B. Sanders, Fangfang Xia, Jinhai Huang, Wanqing Jin
Summary: This study compared the efficacy and safety of corneal refractive therapy (CRT) lenses and vision shaping treatment (VST) lenses for myopia control in children. The results showed that compared with VST lenses, CRT lenses had a weaker effect on myopia control but were safer. Different types of VST lenses had similar efficacy and safety in controlling myopia progression.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Zhen Yi, Shen Jing, Wang Wenhua, Li Qian, Wang Ningli
Summary: The study demonstrates that the new fitting algorithm accurately calculates the AC value of orthokeratology lenses suitable for Chinese patients. Compared to the traditional method, the new algorithm requires fewer lens trials, but there is no significant difference in AC values between the two methods.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Ophthalmology
Mark A. Bullimore, Maria Liu
Summary: This paper comprehensively reviews the published studies on the efficacy of the Euclid Emerald lens designs for orthokeratology in slowing myopia progression in children. The results demonstrate that this lens design is effective in slowing axial elongation in myopic children.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Medicine, General & Internal
Kai Yip Choi, Jimmy K. W. Cheung, Gigi T. K. Wong, Peter H. Li, Sonia S. H. Chan, Thomas C. Lam, Henry H. L. Chan
Summary: The study evaluated the myopia control efficacy and long-term safety of the Breath-O-Correct orthokeratology (OK) lens using a 2-year randomized, single-blind clinical trial. The results showed that the OK lens significantly reduced axial length elongation in schoolchildren without adverse clinical effects or subclinical inflammatory responses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Sin Wan Cheung, Maureen Valerie Boost, Pauline Cho
Summary: The study found that using a povidone iodine-based rigid lens disinfecting solution effectively reduced contamination rates of lenses and lens cases and conjunctival colonization. Regardless of the cleaning routine adopted, there were no significant differences observed in conjunctival colonization or contamination of lenses or cases.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Liyuan Sun, Xuewei Li, Heng Zhao, Yan Li, Kai Wang, Jia Qu, Mingwei Zhao
Summary: The purpose of this study was to investigate the relationship between patients' baseline biometric factors or lens parameters and the diameter of the treatment zone in young myopic children undergoing Corneal Refractive Therapy. Retrospective review of data from patients undergoing Corneal Refractive Therapy lens treatment within two years was conducted. Results showed that spherical refraction, flat keratometric reading, Reverse Zone Depth 2, Landing Zone Angle 1, and lens diameter were independent factors of treatment zone diameter. Logistic regression analysis accurately predicted the treatment zone size with a 71.5% accuracy.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Jianxia Fang, Zhu Huang, Yan Long, Miaomiao Zhu, Qin Wu, Xiaojun Chen, Wei Xv, Chixin Du
Summary: This study compared the effectiveness of multifocal soft contact lenses (MFSCLs), orthokeratology contact lenses (Ortho-kCLs), and single vision spectacles (SVSs) for myopia control. The results showed that wearing MFSCLs and Ortho-kCLs significantly delayed myopia progression compared to SVSs.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Ophthalmology
Biyue Guo, Sin Wan Cheung, Randy Kojima, Pauline Cho
Summary: The purpose of this study was to compare the axial elongation (AE) and treatment zone (TZ) characteristics in children wearing 6 mm or 5 mm orthokeratology lenses over 2 years. The results showed that children wearing 5 mm lenses had a smaller TZ diameter and less AE after 24 months of treatment, with no difference in choroidal thickness changes. In conclusion, using orthokeratology lenses with a smaller back optic zone diameter can slow down axial elongation in children.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Ophthalmology
Kim Duong, Gerald McGwin, Quentin X. Franklin, Jared Cox, Andrew D. Pucker
Summary: The study aimed to determine whether refitting symptomatic soft contact lens wearers into orthokeratology lenses could improve ocular symptoms and signs. Results showed that after 3 months, subjects who were wearing orthokeratology had significant improvement in ocular symptoms, although not all symptomatic wearers were successfully refitted. Additional research is needed to understand the mechanism behind the improved comfort.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Biochemical Research Methods
Guoting Qin, Cecilia Chao, Lauren J. Lattery, Hong Lin, Wenjiang Fu, Kathryn Richdale, Chengzhi Cai
Summary: Contact lens-related ocular surface complications are more common in teenagers and young adults. This study investigated the changes in tear proteome of young patients wearing glasses, orthokeratology lenses, and soft contact lenses. The results showed that tear proteomes were altered by orthokeratology and soft contact wear and age. These findings highlight the need for further research on the ocular surface responses to contact lens wear in teenagers and young adults separately.
JOURNAL OF PROTEOMICS
(2023)
Article
Medicine, General & Internal
Changfei Li, Li Zeng, Jiaqi Zhou, Bingjie Wang, Zhi Chen
Summary: This retrospective study investigated the relationship between the toricity of dual-axis corneal refractive therapy (CRT) orthokeratology lenses and corneal parameters. The study found a positive correlation between corneal astigmatism and the difference in elevation at 8 mm chord length with CRT lens toricity. The difference in elevation at 8 mm chord length can be used to estimate CRT lens toricity in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Jason K. Lau, Kin Wan, Pauline Cho
Summary: The study aimed to investigate the effectiveness of orthokeratology (ortho-k) lenses for myopia control and the corneal changes with increased compression factor. The findings showed that ortho-k lenses with increased compression factor can effectively slow down the progression of myopia without compromising corneal health. Further research is needed to confirm the potential mechanism of an increased compression factor for improved myopia control effectiveness.
CONTACT LENS & ANTERIOR EYE
(2023)
Review
Medicine, General & Internal
Hou-Ren Tsai, Jen-Hung Wang, Huei-Kai Huang, Tai-Li Chen, Po-Wei Chen, Cheng-Jen Chiu
Summary: This study compared the efficacy of atropine, Ortho-K, and combined atropine with Ortho-K for childhood myopia through a network meta-analysis. The results showed that different dosages of atropine and combined treatment could effectively slow down myopic progression, and the efficacy of atropine was dose-related. Additionally, Ortho-K and low-dose atropine had similar efficacy, and the combination of 0.01% atropine with Ortho-K had comparable efficacy to high-dose atropine.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, Research & Experimental
Ying Yuan, Chengcheng Zhu, Mingming Liu, Yali Zhou, Xiao Yang, Bingru Zheng, Zhouyue Li, Xinjie Mao, Bilian Ke
Summary: This study aims to compare the efficacy of using a combination of OK lens and 0.01% atropine versus monotherapy of OK lens in controlling myopia in children. The primary outcome will be determined by observing the axial length differences between the two groups over a 24-month follow-up period, to evaluate the effects of different treatment protocols on myopia control.
Article
Ophthalmology
Angelica C. Scanzera, Elmer Y. Tu, Charlotte E. Joslin
Summary: The study aimed to explore whether orthokeratology may increase the frequency of Acanthamoeba keratitis compared with other lens modalities. Findings showed that the proportion of orthokeratology cases among AK minors exceeded the expected proportion based on market penetrance, suggesting a potential increased risk of AK in orthokeratology users.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Ophthalmology
Tianpu Gu, Boteng Gong, Daqian Lu, Weiping Lin, Na Li, Qing He, Ruihua Wei
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2019)
Article
Ophthalmology
Tianpu Gu, Bei Du, Hua Bi, Lu Zhou, Guihua Liu, Nan Jin, Zhuzhu Liu, Bin Zhang, Ruihua Wei
CURRENT EYE RESEARCH
(2020)
Article
Ophthalmology
Tianpu Gu, Lu Zhao, Zhuzhu Liu, Shaozhen Zhao, Hong Nian, Ruihua Wei
Article
Ophthalmology
Bei Du, Nan Jin, Xiurui Zhu, Daqian Lu, Chengcheng Jin, Zhen Li, Chunle Han, Yani Zhang, Donghai Lai, Kang Liu, Ruihua Wei
EXPERIMENTAL EYE RESEARCH
(2020)
Article
Ophthalmology
Qiong Wang, Xiaowen Ji, Daqian Lu, Ying Zhu, Amy Whelchel, Jingyi Wang, Hongmei Zhang, Lijie Dong, Ruihua Wei
Summary: The Lenstar optical biometer showed better repeatability and provided smaller measurements for Delta L, VCD, and ASD compared to A-scan ultrasonography. There was a high correlation between the two devices in measuring Delta AL. While the devices did not agree in absolute measurements, the Lenstar can still be considered as an option in measuring the difference in AL between eyes in a guinea pig myopia model.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ying Zhu, Jing Fang Bian, Da Qian Lu, Chi Ho To, Carly Siu-Yin Lam, King Kit Li, Feng Juan Yu, Bo Teng Gong, Qiong Wang, Xiao Wen Ji, Hong Mei Zhang, Hong Nian, Thomas Chuen Lam, Rui Hua Wei
Summary: This study investigated the retinal protein changes in a form-deprived myopic guinea pig model treated with 1% atropine gel. The results revealed the involvement of retinal EIF2 signaling, glycolysis, and dopamine secretion pathways in atropine treatment of myopia. The study utilized next-generation proteomics to provide molecular evidence for the mechanism of atropine's effect on myopia progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhang, Jiangmei Wu, Daqian Lu, Chi-Ho To, Thomas Chuen Lam, Bin Lin
Summary: This study investigated the changes in the retinal proteomic profile in the EIU mouse model using mass spectrometry analysis. The study identified differentially expressed proteins related to uveitis and acute retinal inflammation, and identified important pathways associated with these conditions. These findings provide potential candidates for exploring the mechanism and novel therapeutic targets for uveitis and other retinal inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ying Zhu, Jingfang Bian, Daqian Lu, Qiong Wang, Boteng Gong, King-Kit Li, Fengjuan Yu, Jimmy Ka-Wai Cheung, Xiaowen Ji, Hongmei Zhang, Bei Du, Hong Nian, Chi-ho To, Ruihua Wei, Thomas Chuen Lam