Article
Ophthalmology
David H. W. Steel, Niall Patton, Theodor Stappler, Niral Karia, Hans Hoerauf, Nishal Patel, Joachim Wachtlin, Thomas Raber, Petra Kozma-Wiebe
Summary: The INJECT study demonstrated the effectiveness of ocriplasmin in patients with VMT, including those with MH. The study found that in the overall group, the rate of nonsurgical VMT resolution was 40.7%, with a nonsurgical MH closure rate of 36.0%.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Heejeong Chun, Joo Young Kim, Jae Hyuck Kwak, Rae Young Kim, Mirinae Kim, Young-Gun Park, Young-Hoon Park
Summary: The study evaluated the effects of cataract surgery combined with pars plana vitrectomy on choroidal vascularity index in eyes with epiretinal membrane or full thickness macular hole. The results showed that vitrectomy decreased CVI, possibly due to traction removal or postoperative inflammation, while combined surgery initially increased CVI, indicating vascular dilatation or congestion. Thorough inflammation control may be essential after combined surgery.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Andreas Katsanos, Konstantina Gorgoli, Ioannis Asproudis, Maria Stefaniotou
Summary: This case report describes a recurrent vitreomacular traction and macular edema in an 82-year-old male patient who underwent treatment with ocriplasmin injections. Despite initial improvement post-injection, the VMT symptoms recurred. A conservative approach with observation eventually led to resolution of the VMT. More than 3 years after the injection, there is no evidence of VMT, the patient is free of metamorphopsia, and his BCVA is 0.0 logMAR.
OPHTHALMOLOGY AND THERAPY
(2021)
Article
Ophthalmology
Michael Mueller, Frank Koch, Pankaj Singh, Thomas Kohnen
Summary: After an uneventful intravitreal injection (IVI) of Ocriplasmin, a patient with vitreomacular traction and macular hole developed severe retinal detachment within a few days post-operation. This case highlights the importance of discussing potential complications and investigating reasons for excessive reactions in preoperative patient informed consent.
Review
Ophthalmology
Timothy L. Jackson, Julia Haller, Koenraad H. Blot, Luc Duchateau, Benedicte Lescrauwaet
Summary: This study systematically reviewed the effects of Ocriplasmin on VMT and investigated the impact of baseline covariates on the outcomes. The results showed that Ocriplasmin can promote VMAR and MH closure, reduce the need for vitrectomy, and improve BCVA. However, Ocriplasmin treatment may cause transient visual impairment and other adverse events.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Dimosthenis Mantopoulos, Jonathan L. Prenner, Vishal K. Patel, Daniel B. Roth, Sumit P. Shah, Onoufrios Tsavaris, Howard F. Fine, H. Matthew Wheatley
Summary: The effect of cataract extraction on the vitreomacular interface varies significantly, with Stage 2 or 3 macular hole patients all progressing to Stage 4 macular hole after surgery. The vitreomacular adhesion did not significantly change in diabetic patients' eyes. Larger studies are needed to further understand the impact of cataract extraction on vitreomacular traction.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Kai Yuan Tey, Qiu Ying Wong, Yee Shan Dan, Andrew S. H. Tsai, Daniel S. W. Ting, Marcus Ang, Gemmy Chiu Ming Cheung, Shu Yen Lee, Tien Yin Wong, Quan V. Hoang, Chee Wai Wong
Summary: This study found that in highly myopic eyes, myopic traction maculopathy and posterior staphyloma are independently associated with myopic macular degeneration.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Wen-Fei Zhang, Xin-Yu Zhao, Li-Hui Meng, Dong-Yue Wang, Shi Feng, You-Xin Chen
Summary: Ocriplasmin is an effective and relatively safe intervention for VMT, especially for patients younger than 65 years old, with smaller adhesion size (<1500 mu m), with macular hole and subretinal fluid.
ACTA OPHTHALMOLOGICA
(2022)
Article
Multidisciplinary Sciences
Minho Kim, Soonil Kwon, Sohee Jeon, Byung Ju Jung, Kyu Seop Kim
Summary: Abnormal posterior vitreous detachment (PVD) is speculated to be an important mechanism in the development of epiretinal membrane (ERM). Sphingosine-1-phosphate (S1P) has been found to be expressed in ERM specimens, indicating its potential role in the pathogenesis of ERM during abnormal PVD.
Article
Ophthalmology
Yue Qi, Pengyou Yan, Wenying Fan, Ningli Wang, An Li Duan
Summary: A retrospective study was conducted to compare the outcomes of vitrectomy with and without fovea-sparing internal limiting membrane (ILM) peeling for highly myopic eyes with retinoschisis and foveal detachment. The results showed that fovea-sparing ILM peeling had better anatomical outcomes in resolving foveoschisis and foveal detachment compared to non-ILM peeling, while both procedures had similar visual functional outcomes.
Article
Medicine, General & Internal
Lei Shao, Chuan Zhang, Li Dong, Wen Da Zhou, Rui Heng Zhang, Wen Bin Wei
Summary: The study revealed that the prevalence of vitreous macular traction (VMT) in the Chinese adult population in Greater Beijing was 2.3% to 2.4%, and was associated with older age, female gender, thicker subfoveal retinal thickness, and thinner subfoveal choroidal thickness.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Ophthalmology
Yi-Ting Hsieh, Chung-May Yang
Summary: This study retrospectively analyzed 30 patients with diabetic retinopathy and concurrent vitreomacular traction (VMT), and found that VMT in diabetic retinopathy had unique characteristics, including thickened posterior hyaloid membrane and multi-layered traction from different directions. Surgical treatment can improve visual acuity and macular structures.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Akinori Uemura, Syoki Miyake, Ryoh Funatsu, Keita Yamakiri
Summary: This study investigated the clinical characteristics and surgical outcomes of Stage 4 macular holes (MHs) with epiretinal proliferation (EP). The results showed that patients with EP were older, predominantly male, and had better preoperative and postoperative visual acuity compared with those without EP. Optical coherence tomography findings indicated that eyes with EP had more epiretinal membrane and intraretinal splitting. The presence of complete posterior vitreous detachment before MH development was documented in some patients with EP.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Editorial Material
Ophthalmology
Feng Jiang, Wen-wen Zhang, Ya-jun Liu, Fei-fei Chen, Zheng-gao Xie
Summary: Supplemental digital content is available in the text.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Cemal Ozsaygili, Bekir Kucuk, Yener Yildirim
Summary: In this retrospective cohort study of treatment-naive diabetic macular oedema patients, the efficacy of aflibercept treatment in improving central retinal thickness and best-corrected visual acuity was not affected by the presence or development of posterior vitreous detachment (PVD).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Janice Sutton, Martin J. Menten, Sophie Riedl, Hvroje Bogunovic, Oliver Leingang, Philipp Anders, Ahmed M. Hagag, Sebastian Waldstein, Amber Wilson, Angela J. Cree, Ghislaine Traber, Lars G. Fritsche, Hendrik Scholl, Daniel Rueckert, Ursula Schmidt-Erfurth, Sobha Sivaprasad, Toby Prevost, Andrew Lotery
Summary: This study aims to utilize machine learning and advanced statistical modeling to discover biomarkers for disease progression in intermediate age-related macular degeneration (AMD) and report the natural history of its progression through multimodal retinal imaging.
Article
Ophthalmology
Lindsay Prior, Noemi Lois
Summary: This study explores the acceptability of a new surveillance pathway for patients with previously treated and stable diabetic macular oedema (DMO) and/or proliferative diabetic retinopathy (PDR) from the perspectives of patients and healthcare professionals. The study finds that patients are concerned about the expertise of professionals, the quality of interactions with professionals, and the need for holistic treatment. Ophthalmologists tend to overlook the deeper implications of patient concerns for the organization of services, focusing on patient education as the solution.
Article
Ophthalmology
Shi Zhuan Tan, David H. Steel, Boris Stanzel, Martin Bedersdorfer, Peter Szurman, Shohista Saidkasimova, Katja Christina Schielke, Neruban Kumaran, David Alistair H. Laidlaw
Summary: This study investigated the safety and effectiveness of pre-emptive vitrectomy in eyes with severe non-fibrotic proliferative diabetic retinopathy. The results showed that pre-emptive vitrectomy did not lead to sight loss and maintained better eye status in this high-risk group.
Article
Anatomy & Morphology
Mona J. Albargothy, Nadhira N. Azizah, Sarah L. Stewart, Evan P. Troendle, David H. W. Steel, Tim M. Curtis, Michael J. Taggart
Summary: The retina is a complex structure with various cells that work together for vision. The retinal capillaries form a neurovascular unit (NVU) consisting of neural, glial, and vascular elements. NVU is essential for regulating blood flow in response to changes in the environment, and its dysfunction is associated with diseases like diabetic retinopathy. This study utilizes advanced imaging techniques to analyze the 3D structure of NVU in mouse retinal capillaries, providing valuable insights into its composition and potential implications for structural integrity and function.
JOURNAL OF ANATOMY
(2023)
Article
Ophthalmology
Samar Yahya, Claire E. L. Smith, James A. Poulter, Martin McKibbin, Gavin Arno, Jamie Ellingford, Kati Kampjarvi, Muhammad Khan, Frans P. M. Cremers, Alison J. Hardcastle, Bruce Castle, David H. W. Steel, Andrew R. Webster, Graeme C. Black, Mohammed E. El-Asrag, Manir Ali, Carmel Toomes, Chris F. Inglehearn
Summary: The purpose of this study was to characterize the phenotype observed in a case series with macular disease and determine the cause. Through ophthalmic examination and genetic sequencing, it was found that all patients carried the same gene deletion that caused late-onset macular disease.
Article
Ophthalmology
Noemi Lois, Christina Campbell, Norman Waugh, Augusto Azuara-Blanco, Mandy Maredza, Hema Mistry, Danny McAuley, Nachiketa Acharya, Tariq M. Aslam, Clare Bailey, Victor Chong, Louise Downey, Haralabos Eleftheriadis, Samia Fatum, Sheena George, Faruque Ghanchi, Markus Groppe, Robin Hamilton, Geeta Menon, Ahmed Saad, Sobha Sivaprasad, Marianne Shiew, David H. Steel, James Stephen Talks, Paul Doherty, Cliona McDowell, Mike Clarke
Summary: The purpose of this study was to compare the clinical effectiveness, safety, and cost-effectiveness of subthreshold micropulse laser (SML) and standard laser (SL) for diabetic macular edema (DME) with central retinal thickness (CRT) < 400 μm. The results showed that SML therapy was equivalent to SL therapy and required slightly more laser treatments.
Article
Ophthalmology
Alasdair N. Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Summary: This study describes the grading methods and baseline characteristics for UK Biobank participants who underwent retinal imaging, and characterizes individuals with retinal features suggestive of age-related macular degeneration, glaucoma, and retinopathy. The results provide important insights into both ocular and systemic health.
Article
Ophthalmology
Boon Lin Teh, Mohaimen Al-Zubaidy, Roxane J. Hillier, David H. Steel
Article
Ophthalmology
Timothy H. M. Fung, Neville C. R. A. John, Jean-Yves Guillemaut, David Yorston, David Frohlich, David H. W. Steel, Tom H. Williamson
Summary: This study developed an automated deep learning model to predict the anatomical outcome of rhegmatogenous retinal detachment surgery. By using a large dataset of digital images, the model was able to accurately predict the surgical outcome.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Flavio A. Rezende, Bruna G. Ferreira, Emmanouil Rampakakis, David H. Steel, Michael J. Koss, Zofia A. Nawrocka, Daniela Bacherini, Eduardo B. Rodrigues, Carsten H. Meyer, Tomaso Caporossi, Tamer H. Mahmoud, Stanislao Rizzo, Mark W. Johnson, Jay S. Duker
Summary: The CLOSE study group proposes an updated surgical classification for large macular holes based on a systematic review of new treatments. The need for an updated surgical classification arises from the introduction of many new techniques to treat large macular holes, but the indications are unclear.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Article
Medicine, General & Internal
Sajjad Haider, Nicola Adderley, Mohammad O. Tallouzi, Salman Naveed Sadiq, David H. Steel, Randhir Chavan, Ijaz Sheikh, Krishnarajah Nirantharakumar, Kym I. E. Snell
Summary: The prevalence of diabetes mellitus is increasing worldwide, which leads to a rise in diabetic retinopathy. The current screening method for diabetic retinopathy is primarily based on the stage of retinopathy, but other individual risk factors such as glycated hemoglobin (HbA1c) may also be useful. This study aims to validate a prediction model that combines multiple prognostic factors to predict disease progression and improve triage for patients.
Article
Medicine, General & Internal
Rosie Clark, Samantha Sze-Yee Lee, Ran Du, Yining Wang, Sander C. M. Kneepkens, Jason Charng, Yu Huang, Michael L. Hunter, Chen Jiang, J. Willem L. Tideman, Ronald B. Melles, Caroline C. W. Klaver, David A. Mackey, Cathy Williams, Helene Choquet, Kyoko Ohno-Matsui, Jeremy A. Guggenheim
Summary: This study aimed to predict the risk of high myopia (HM) through an improved polygenic score (PGS) and test if the PGS is predictive of myopic macular degeneration (MMD) after considering refractive error. The study found that PGS can predict the risk of HM in Europeans, but its predictive ability is weaker in other populations.
Review
Medicine, General & Internal
Sarah Hammadi, Nikolaos Tzoumas, Mariantonia Ferrara, Ingrid Porpino Meschede, Katharina Lo, Claire Harris, Majlinda Lako, David H. Steel
Summary: The complement system is essential for the body's defense against pathogens, but dysregulation can lead to diseases such as age-related macular degeneration (AMD). Complement activation occurs in various parts of the eye, including the choriocapillaris and the subretinal and retinal pigment epithelium spaces. The barrier of Bruch's membrane impedes complement protein diffusion and its dysfunction contributes to AMD pathogenesis. This review examines the structure of Bruch's membrane, its age-related changes, and the potential of different delivery routes for complement inhibitors in treating AMD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Mahsa Vali, Behzad Nazari, Saeed Sadri, Elias Khalili Pour, Hamid Riazi-Esfahani, Hooshang Faghihi, Nazanin Ebrahimiadib, Momeneh Azizkhani, Will Innes, David H. H. Steel, Anya Hurlbert, Jenny C. A. Read, Rahele Kafieh
Summary: This paper presents an artificial intelligence-based algorithm for automated segmentation of Choroidal Neovascularization (CNV) areas and identification of CNV activity criteria in OCTA images. The proposed algorithm includes pre-processing and segmentation of CNVs using a modified U-Net network, as well as binary classification networks for evaluating different activity criteria. Results show high accuracies for segmentation and classification, indicating that the AI-based algorithm allows reliable detection and assessment of CNV features from OCTA alone.
Article
Ophthalmology
Martin J. Menten, Robbie Holland, Oliver Leingang, Hrvoje Bogunovic, Ahmed M. Hagag, Rebecca Kaye, Sophie Riedl, Ghislaine L. Traber, Osama N. Hassan, Nick Pawlowski, Ben Glocker, Lars G. Fritsche, Hendrik P. N. Scholl, Sobha Sivaprasad, Ursula Schmidt-Erfurth, Daniel Rueckert, Andrew J. Lotery
Summary: This study used deep learning to investigate the individual course of retinal changes caused by healthy aging. By analyzing a large data set of retinal OCT images, a counterfactual generative adversarial network (GAN) was created to generate high-resolution OCT images and longitudinal time series. The results showed that the thickness of the retinal nerve fiber layer, combined ganglion cell layer plus inner plexiform layer, inner nuclear layer to the inner boundary of the retinal pigment epithelium, and retinal pigment epithelium changed with age.
OPHTHALMOLOGY SCIENCE
(2023)