Letter
Medicine, General & Internal
Katharina S. Shaw, Ahmad Rajeh, Todd Le, Philip J. Kahn, Vikash S. Oza, Lisa M. Arkin, Ruth Ann Vleugels
Summary: This case series examines the effectiveness of anifrolumab in treating adolescent patients with systemic lupus erythematosus and refractory discoid lupus erythematosus.
Article
Dermatology
Tatiana Hawat, Salwa Ballouz, Hala Megarbane, Roger Haber
Summary: Pediatric discoid lupus erythematosus (DLE) predominantly affects the head and neck with a female predominance, possibly associated with inflammatory and autoimmune diseases, and shows overall good treatment response and prognosis.
DERMATOLOGIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Paolo Fagone, Eliana Piombino, Katia Mangano, Rocco De Pasquale, Ferdinando Nicoletti, Rosario Caltabiano
Summary: This study found a negative correlation between HMOX1 levels and the inflammatory status, as well as the infiltration of M1 macrophages and activated mastocytes in DLE lesions. These findings suggest that HMOX1 plays a crucial role in the regulation of inflammation in DLE and could be a potential therapeutic target and biomarker for DLE.
Article
Dermatology
N. Ezeh, K. Ardalan, K. A. Buhr, C. Nguyen, O. Al Ahmed, S. P. Ardoin, V Barton, S. Bell, H. Brandling-Bennett, L. Castelo-Soccio, Y. E. Chiu, B. F. Chong, D. O. Co, I Lara-Corrales, A. Cintosun, M. L. Curran, L. Z. Diaz, S. A. Elman, E. Fernandez Faith, M. T. Garcia-Romero, J. Grossman-Kranseler, M. Hogeling, A. D. Hudson, R. D. Hunt, E. M. Ibler, M. C. Marques, R. L. Monir, V Oza, A. S. Paller, E. Putterman, P. Rodriguez-Salgado, J. J. Schoch, A. Truong, J. Wang, L. Wine Lee, R. A. Vleugels, M. S. Klein-Gitelman, E. von Scheven, V. P. Werth, Lisa M. Arkin
Summary: This study assessed the baseline characteristics of pediatric patients with discoid lupus and found that patients with clinically aggressive features were more likely to have systemic lupus erythematosus.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Wenting Hu, Si Zhang, Cuihong Lian
Summary: In this report, the efficacy and safety of upadacitinib, a JAK1 selective inhibitor, in treating a patient with discoid lupus erythematosus (DLE) for 28 weeks were evaluated. The results showed significant improvement of DLE lesions with upadacitinib treatment, indicating it could be a potential alternative therapy for DLE.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Review
Dermatology
Magdalena Zychowska, Malgorzata Zychowska
Summary: Discoid lupus erythematosus (DLE) can lead to scarring and hair loss, with dermoscopy serving as a useful tool in preliminary diagnosis. The study summarized dermoscopic features of DLE lesions in various locations, showing a wide variety of features with variable frequencies depending on the location. Further research is needed to reliably assess frequencies, correlation with disease stage, and significance of individual dermoscopic features.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Zsofia Kiraly, Eszter Nagy, Laura Bokor, Aniko Kovacs, Marta Marschalko, Bernadett Hidvegi
Summary: This study explored the levels of soluble programmed cell death 1/programmed cell death ligand 1 (sPD-1/sPD-L1) in untreated discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE) patients. The results showed that there were no significant differences in sPD-1 levels between DLE and SCLE groups, but the sPD-L1 level in the DLE group was significantly lower compared to the healthy control group. This suggests that alterations in the inhibitory effect of sPD-L1 on T-cell activity may explain the differences between DLE and SCLE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Veterinary Sciences
Estefany De Leon-Robles, Mariana Colmenares, Gylari Mhelanya Calderon
Summary: An 11-year-old male Golden Retriever presented with a chronic progressive lesion on the nose, diagnosed as discoid lupus erythematosus. However, the therapeutic protocol did not result in improvement.
VETERINARY MEDICINE AND SCIENCE
(2023)
Letter
Dermatology
Katharina Shaw, Stephanie Sanchez-Melendez, Dustin Taylor, Julia Barker, Avery LaChance, Neda Shahriari, Ruth Ann Vleugels
Summary: This case series investigates the effectiveness of anifrolumab as a treatment option for patients with lupus erythematosus.
Review
Pharmacology & Pharmacy
J. Freire de Carvalho, T. Larocca Skare, C. Figueiredo, P. R. Criado
Summary: This study reports on a case of a patient with discoid lupus erythematosus (DLE) who developed antiphospholipid syndrome (APS) 12 years after DLE diagnosis, and reviews related literature. The study found that APS can develop even several decades after DLE diagnosis, and patients with DLE often have anticardiolipin antibodies.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Dermatology
Ahmed H. Nouh, Ahmed R. Elshahid, Ahmed S. Kadah, Youssef A. Zeyada
Summary: Topical Nicotinamide can be used as an adjuvant therapy for Discoid lupus erythematosus, with good cosmetic results and minimal side effects, as shown in a prospective randomized double-blind clinical trial.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sudha Damarla, Brahmaiah Upputuri
Summary: Systemic lupus erythematosus is an autoimmune disorder that typically affects women, but can also occur in males. Isolated bilateral periorbital involvement is a rare presentation that may delay diagnosis and treatment. This case report highlights a unique presentation of the disease in a male patient.
Article
Medicine, General & Internal
Qian Dong, Kang Chen, Jinye Xie, Hui Han, Yanping Feng, Jianqiang Lu, Weijia Wang
Summary: Key differentially expressed genes (DEGs) were identified in discoid lupus skin, with a focus on their role in receptor signaling pathways of the immune response. Further analysis revealed upregulated genes associated with the RIG-I-like receptor signaling pathway, providing potential insights into the molecular mechanisms of DLE. Further experimentation is needed for confirmation of these findings.
Article
Dermatology
Federico Bardazzi, Giuseppe Gallo, Camilla Loi, Cosimo Misciali, Annalisa Patrizi, Andrea Filippini
Summary: Palmo-plantar lesions in discoid lupus erythematosus (DLE) are considered a rare condition that is often refractory to conventional treatments. This case report suggests that therapy with mycophenolate mofetil (MMF) may be an effective and safe approach for managing refractory palmo-plantar DLE.
DERMATOLOGIC THERAPY
(2021)
Article
Ophthalmology
Alexandra Van Brummen, Julia P. Owen, Theodore Spaide, Colin Froines, Randy Lu, Megan Lacy, Marian Blazes, Emily Li, Cecilia S. Lee, Aaron Y. Lee, Matthew Zhang
Summary: This study developed a deep learning semantic segmentation network to automate the assessment of 8 periorbital measurements, using an artificial intelligence algorithm trained and tested on 418 photographs of periorbital areas. The AI algorithm showed close agreement with human graders, demonstrating high accuracy and consistency.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
R. L. Scawn, D. H. Verity, G. E. Rose
Article
Ophthalmology
S. Hamed-Azzam, D. H. Verity, G. E. Rose
Article
Ophthalmology
Shirin W. Hamed-Azzam, David P. D'Cruz, David H. Verity
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2018)
Article
Ophthalmology
Ilse Mombaerts, Jurij R. Bilyk, Geoffrey E. Rose, Alan A. McNab, Aaron Fay, Peter J. Dolman, Richard C. Allen, Martin H. Devoto, Gerald J. Harris
JAMA OPHTHALMOLOGY
(2017)
Review
Ophthalmology
A. M. Porteous, A. S. Haridas, J. R. O. Collin, D. H. Verity
Article
Ophthalmology
Richard L. Scawn, Matthew J. Allen, Geoffrey E. Rose, David H. Verity
Article
Oncology
Anna M. Rose, Rong Luo, Utsav K. Radia, Helen Kalirai, Sophie Thornton, Philip J. Luthert, Channa N. Jayasena, David H. Verity, Sarah E. Coupland, Geoffrey E. Rose
Letter
Ophthalmology
Swan Kang, Shirin Hamed-Azzam, Fergus Robertson, Indran Davagnanam, David H. Verity
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2020)
Article
Ophthalmology
Aaron Fay, Nambi Nallasamy, Richard C. Allen, Francesco P. Bernardini, Jurij R. Bilyk, Kimberly Cockerham, Antonio Augusto Cruz, Martin Devoto, Peter J. Dolman, Jonathan J. Dutton, David R. Jordan, Robert Kersten, Yoon-Duck Kim, Mark J. Lucarelli, Alan A. McNab, Ilse Mombaerts, Maarten Mourits, Jeffrey Nerad, Julian D. Perry, Geoffrey Rose, Peerooz Saeed, Lay Leng Seah, Dinesh Selva, Jennifer Sivak-Callcott, Diego Strianese, David H. Verity
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
Article
Ophthalmology
Francesco M. Quaranta-Leoni, Dion Paridaens, David Verity
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2020)
Article
Ophthalmology
Swan Kang, Mohammad H. Dehabadi, Geoffrey E. Rose, David H. Verity, Sepideh Amin, Raja Das-Bhaumik
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2020)
Review
Ophthalmology
Shirin Hamed-Azzam, Islam AlHashash, Daniel Briscoe, Geoffrey E. Rose, David H. Verity
JOURNAL OF OPHTHALMIC & VISION RESEARCH
(2018)
Review
Ophthalmology
Shirin Hamed-Azzam, Islam AlHashash, Daniel Briscoe, Geoffrey E. Rose, David H. Verity
JOURNAL OF OPHTHALMIC & VISION RESEARCH
(2018)
Article
Ophthalmology
Sri K. Gore, Nicholas P. Plowman, Aruna Dharmasena, David H. Verity, Geoffrey E. Rose
BRITISH JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Medicine, General & Internal
Omer Jamall, Korina Theodoraki, Sepideh Amin, David Verity, Adam Bates