Article
Medicine, General & Internal
Jiarui Yang, Huaqin Xia, Yushi Liu, Xinglin Wang, Hao Yuan, Qingyi Hou, Yimeng Ge, Yi Ding, Yuexin Wang, Changguan Wang, Xuemin Li
Summary: The study compared the structural diameters of the EZ and ELM bands on SD-OCT images between vision-improved and vision-unimproved patients, finding significant differences in parameters and their correlation with visual prognosis. Postoperative BCVA outcome was significantly correlated with integrity, thickness and reflectivity of the EZ band. Patients with smaller diameter of EZ disruption and higher reflectivity of EZ band tended to have better visual outcomes, suggesting EZ band as a promising parameter for functional evaluation of photoreceptors.
FRONTIERS IN MEDICINE
(2021)
Article
Biology
Vivek Kumar Singh, Burak Kucukgoz, Declan C. Murphy, Xiaofan Xiong, David H. Steel, Boguslaw Obara
Summary: This study establishes a new benchmark for the segmentation of the retinal external limiting membrane in patients with idiopathic full-thickness macular holes using spectral domain optical coherence tomography images. The annotation of ELM line was performed with precise image-wise binary annotations after extensive quality analysis of OCT imaging and annotation data. Comparison with seven state-of-the-art machine learning-based segmentation methods was conducted to identify the ELM line with an automated system.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Ophthalmology
Ivastinovic Domagoj, Haas Anton, Weger Martin, Seidel Gerald, Mayer-Xanthaki Christoph, Lindner Ewald, Guttmann Andreas, Wedrich Andreas
Summary: The study evaluated the relevance of external limiting membrane (ELM) in eyes with diabetic macular edema (DME) post pars plana vitrectomy (PPV). Eyes with intact ELM preoperatively had significantly better final visual outcomes. Early PPV treatment is recommended for DME patients with intact ELM to maximize benefits.
Article
Ophthalmology
Dhananjay Shukla, Jay Kalliath
Summary: This study reports a modified internal limiting membrane (ILM) peeling surgery tailored to the shape of macular holes, aiming to improve closure rates. The results showed that the macular holes were horizontally oval in shape, and a corresponding enlargement of the ILM rhexis yielded excellent anatomical and satisfactory visual outcomes.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
An-Lun Wu, Ya-Tung Liu, Hung-Da Chou, Lan-Hsin Chuang, Kuan-Jen Chen, Yen-Po Chen, Laura Liu, Ling Yeung, Nan-Kai Wang, Yih-Shiou Hwang, Wei-Chi Wu, Chi-Chun Lai
Summary: This study demonstrated the significant effects of various growth factors and internal limiting membrane constituents on Muller cell migration, which may assist in the macular hole healing process.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Medicine, General & Internal
Yiqi Chen, Jun Wang, Xin Ye, Jiafeng Yu, Jiwei Tao, Li Lin, Sulan Wu, Jia Qu, Lijun Shen
Summary: The study showed that the inverted internal limiting membrane (ILM) flap technique was effective in achieving macular hole closure, with higher closure rate compared to ILM peeling. Postoperative best-corrected visual acuity (BCVA) and microstructural restoration were not significantly different between the two groups. Excessive gliosis was identified in the inverted group but did not affect postoperative BCVA, and its incidence was not influenced by the use of adjuvants.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Bianca Pacini, Daniela Bacherini, Alfonso Savastano, Stanislao Rizzo, Tomaso Caporossi
Summary: The study compared the macular microstructures of eyes treated with autologous internal limiting membrane (ILM) transplant and human Amniotic Membrane (hAM) plug transplant for failed macular holes (FMH), revealing important differences in the cellular mechanism underlying tissue remodelling in the two techniques. Additional validation with a larger patient sample and longer follow-up is needed.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Xujia Liu, Jinqu Huang, Ruiqin Zhou, Zehua Jiang, Haoyu Chen, Weiqi Chen, Tsz Kin Ng, Zhenggen Wu, Guihua Zhang
Summary: This study evaluated the outcomes of ILM peeling and the inverted ILM flap technique for rhegmatogenous retinal detachment with macular hole. The inverted ILM flap technique had a higher Type 1 closure rate and similar rates of retinal reattachment and visual improvement compared to ILM peeling.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Nathalie Bleidissel, Julia Friedrich, Julian Klaas, Nikolaus Feucht, Chris Patrick Lohmann, Mathias Maier
Summary: The study demonstrates the favorable morphological and functional outcomes of the I-ILM flap technique in treating large idiopathic full-thickness macular holes, with a 100% closure rate and significant improvement in BCVA over a 12-month follow-up period. Better preoperative BCVA, complete restoration of ELM, higher MHI, and smaller MH base diameter are associated with greater improvements in BCVA.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Hui Qi, Hongtao Yan, Yan Cheng, Ling Zuo
Summary: Terson's syndrome with spontaneous inner limiting membrane (ILM) peeling off combined with macular hole is rare. Patients may have poor visual outcomes due to the extensive ILM peeling off, despite successful closure of the macular hole after surgery.
Article
Ophthalmology
Nurullah Kocak, Volkan Yeter, Hakki Birinci
Summary: The study compares the outcomes of conventional ILM peeling and temporal inverted ILM flap technique for large full-thickness macular holes. The results suggest that the temporal inverted ILM flap technique is more effective in terms of hole closure rate, BCVA improvement, and restoration of the outer retinal layers.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
J. M. Yang, J. -G. Kim
Summary: This study introduces two effective and simple methods to handle the internal limiting membrane during macular hole surgery, including controlling the direction and status of the infusion. With these techniques, the ILM flap can remain stable.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Sunjin Hwang, Min-Ho Kang, Mincheol Seong, Heeyoon Cho, Yong-Un Shin
Summary: This study compared the OCTA findings between eyes with nearly recovered and partially recovered outer retina after FTMH surgery. It was found that the partially recovered group had a significantly higher choriocapillaris flow-void area at six months postoperatively, while the nearly recovered group showed better choroidal vascular flow. Vision at six months postoperatively correlated with the ratio of the operated eye's choriocapillaris flow-void area to the fellow eye.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Ophthalmology
Mariantonia Ferrara, Antonio Rivera-Real, Roxane J. Hillier, Maged Habib, Mustafa R. Kadhim, Maria T. Sandinha, Katie Curran, Alyson Muldrew, David H. W. Steel
Summary: This study compared the effects of using atraumatic ILM forceps and standard forceps on anatomical and functional changes after ILM peeling. The results showed no significant differences in terms of final visual acuity, visual field mean deviation, pick-up-related retinal haemorrhages, swelling of arcuate nerve fibre layer lesions, dissociated optic nerve fibre layer lesions, inner retina defects, and inner retinal volumes between the two groups. The study provided estimates for future studies in this field.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Akira Hirata, Keiko Mine, Ken Hayashi
Summary: Patients who undergo temporal inverted internal limiting membrane (ILM) flap technique for macular hole (MH) show good postoperative outcomes with improved visual acuity and closure of MH. The area of the ILM flap decreases significantly between 1 and 6 months postoperatively, with some patients experiencing flap contraction. Younger age and larger ILM flap area at 1 month postoperatively are correlated with ILM flap contraction.
SCIENTIFIC REPORTS
(2021)
