Review
Ophthalmology
Rafael Jose-Vieira, Andre Ferreira, Pedro Meneres, Bernardo Sousa-Pinto, Luis Figueira
Summary: This study systematically reviewed the evidence on regional corticosteroid delivery modalities in the treatment of noninfectious uveitis. The findings suggest that intravitreal corticosteroid injections are more effective but associated with more adverse events compared to periocular injections. Some evidence supports the use of subconjunctival triamcinolone acetonide. Additionally, the results indicate that a lower dosage of intravitreal fluocinolone acetonide implant may be more beneficial.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Muhammad Usman Jamil, Uzma Naz, Saliha Naz
Summary: This study compared the efficacy of a single intraoperative intravitreal injection of 4 mg triamcinolone acetonide (IVTA) with oral steroids for inflammation control in patients with complicated uveitic cataracts. The results showed that IVTA had similar efficacy to peri-operative oral steroid administration.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Gayathri Tummala, Adam Crain, Jessica Rowlan, Kathryn L. Pepple
Summary: The intravitreal injection of AAV in mice results in mild clinically evident inflammation that tends to resolve spontaneously. However, the total number of intraocular CD45+ cells, particularly T cells, remains elevated. Both innate and adaptive immune cells respond to intravitreal AAV regardless of prior immune status, but the adaptive response is delayed in AAV naive eyes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Yumi Shigemoto, Yoichi Sakurada, Yoshiko Fukuda, Mio Matsubara, Ravi Parikh, Kenji Kashiwagi
Summary: Brolucizumab is effective in treating neovascular AMD, but can cause intraocular inflammation. In this case, combination therapy of brolucizumab and STTA achieved good outcomes after aflibercept failed to control the condition.
Article
Pharmacology & Pharmacy
Steven Castleberry
Summary: There are obstacles in developing intravitreal delivered small molecule therapies, such as the need for complex polymer depot formulations in early stages of drug discovery. A diffusion limited pseudo-steady state model is proposed to predict drug release from intravitreally administered suspension formulation. This model can help preclinical formulators determine if a complex formulation is necessary or if a simple suspension can support a study design. The model is used to predict the intravitreal performance of two different molecules in rabbit eyes and to predict the performance of a marketed formulation in humans.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Letter
Ophthalmology
Ploysai Rujkorakarn, Avery Zhou, Fatima Babiker, Peter Y. Y. Chang
Summary: We report the first case of SCS-TA used in the treatment of posterior scleritis, which resulted in pain relief and improved visual acuity. SCS-TA may be an effective treatment for posterior scleritis, but further studies are needed to establish its long-term efficacy and safety.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, Research & Experimental
Cibele Rodrigues Toledo, Mayara Rodrigues Brandao Paiva, Brenda Fernanda Moreira Castro, Vinicius Viana Pereira, Sarah Pereira de Freitas Cenachi, Daniel Vitor Vasconcelos-Santos, Silvia Ligorio Fialho, Armando Silva-Cunha
Summary: The study found that lupeol significantly reduced levels of inflammatory factors IL-6 and IL-8, demonstrating its anti-inflammatory effects on noninfectious uveitis and suggesting its potential as a new candidate for the treatment of uveitis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Avik Shome, Odunayo O. Mugisho, Rachael L. Niederer, Ilva D. Rupenthal
Summary: Uveitis is a complex ocular inflammatory disease that can be caused by infections or autoimmune factors. While infectious uveitis can often be resolved with anti-infective therapy and corticosteroids, non-infectious uveitis requires a better understanding of inflammatory pathways to develop more effective treatments.
DRUG DISCOVERY TODAY
(2021)
Article
Ophthalmology
Yan Ren, Shufang Du, Dongping Zheng, Yanyun Shi, Luping Pan, Hua Yan
Summary: The study showed that intravitreal 3 mg triamcinolone acetonide injection during phacoemulsification in uveitic cataract patients can effectively reduce postoperative inflammation, improve visual acuity, shorten corticosteroid use, and lower the occurrence of complications.
Review
Pediatrics
Abhay Shivpuri, Inga Turtsevich, Ameenat Lola Solebo, Sandrine Compeyrot-Lacassagne
Summary: The challenges of childhood uveitis lie in its diverse clinical presentations, often asymptomatic nature, and its dynamic nature alongside normal physiological development. Prompt diagnosis by pediatricians can help prevent complications and reduce the risk of irreversible sequelae development.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Tianyu Tao, Shizhao Yang, Daquan He, Zhaohuai Li, Binyao Chen, Lei Zhu, Wenru Su
Summary: This cross-sectional study investigated the efficacy and safety of dexamethasone implant, Ozurdex(R), as an adjunctive treatment for refractory Behcet's uveitis (BU). The study included 61 patients (80 eyes) divided into non-DEX and DEX groups. After >12 months of treatment, the DEX group showed significantly higher improvement in fluorescein angiography score and vitritis score compared to the non-DEX group. Despite worsening posterior capsule opacification score, the DEX group had higher usage of low-dose systemic glucocorticoid and fewer relapse times. Therefore, Ozurdex(R) is an effective and safe option for refractory BU patients, providing control of vasculitis, stabilization of vitreous inflammation, prevention of recurrence, and reduction of daily glucocorticoid doses.
CLINICAL IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
S. Zeng, X. -l. Liu
Summary: This review summarizes the use of DEX-I in uveitis treatment over the past 10 years, discussing its efficacy and safety in various types of uveitis. DEX-I effectively reduces edema, improves inflammation, and enhances vision in uveitis patients. Its efficacy is influenced by factors such as disease etiology, course, systemic treatment, patient toleration, and economic considerations. Intravitreal corticosteroids implantation may replace systemic therapy in some cases. However, there are some safety concerns, such as increased intraocular pressure and cataract formation.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biology
Pradip Nirbhavane, Laxmi Moksha, Gajanand Sharma, Thirumurthy Velpandian, Bhupinder Singh, O. P. Katare
Summary: This study evaluated a novel nano-lipoidal eye drop formulation of triamcinolone acetonide (TA) for the topical treatment of uveitis. The developed triamcinolone acetonide-loaded nanostructured lipid carriers (cTA-NLC) showed sustained release and enhanced efficacy in vitro. In vivo efficacy was tested on Wistar rats and a pharmacokinetic study was conducted in rabbits. The results demonstrated that the cTA-NLC formulation effectively managed uveitis with minimal signs of inflammation.
Letter
Ophthalmology
Aaron PC. Ong, Joanne L. Sims, Rachael L. Niederer
Summary: Infectious uveitis is a visually devastating cause of uveitis worldwide, with a significant percentage of cases in New Zealand. Local steroid and methotrexate injections can lead to infectious uveitis in immunosuppressed patients, with atypical presentations possible. Polymerase chain reaction testing can play a crucial role in diagnosing infectious etiologies of uveitis following local therapy.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Carlos Pavesio, Carsten Heinz
Summary: The study findings suggest that in patients with bilateral non-infectious uveitis of the posterior segment (NIU-PS), the use of 0.2 µg/day fluocinolone acetonide implant (FAi) can effectively reduce recurrence rates, decrease the need for adjunctive medications, and improve visual acuity over a 36-month period.
Article
Ophthalmology
B. Book, M. Ziegler, B. Heimes, M. Gutfleisch, G. Spital, D. Pauleikhoff, A. Lommatzsch
Article
Ophthalmology
Marie-Louise Farecki, Matthias Gutfleisch, Henrik Faatz, Kai Rothaus, Britta Heimes, Georg Spital, Albrecht Lommatzsch, Daniel Pauleikhoff
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Stephan Roehrig, Marie-Louise Farecki, Karl T. Boden, Arno Haus, Matthias Gutfleisch, Sascha Jung, Albrecht Lommatzsch, Peter Szurman, Kai Januschowski
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2019)
Article
Ophthalmology
Henrik Faatz, Marie-Louise Farecki, Kai Rothaus, Frederic Gunnemann, Matthias Gutfleisch, Albrecht Lommatzsch, Daniel Pauleikhoff
Letter
Ophthalmology
Marie-Louise Gunnemann, Stephan Roehrig, Matthias Gutfleisch, Albrecht Lommatzsch, Peter Szurman, Karl Boden, Kai Januschowski
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Marius Book, Martin Ziegler, Kai Rothaus, Henrik Faatz, Marie-Louise Gunnemann, Matthias Gutfleisch, Georg Spital, Albrecht Peter Lommatzsch, Daniel Pauleikhoff
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2020)
Article
Multidisciplinary Sciences
Henrik Faatz, Kai Rothaus, Marie-Louise Gunnemann, Marius Book, Pia Wilming, Matthias Guttleisch, Georg Spital, Albrecht Lommatzsch, Daniel Pauleikhoff
Article
Ophthalmology
Frauke Juergens, Kai Rothaus, Henrik Faatz, Britta Heimes-Bussmann, Daniel Pauleikhoff, Albrecht Peter Lommatzsch
Summary: This study investigated the potential for quantifying early and intermediate AMD using en-face optical coherence tomography, finding that a segmentation 6 mu m underneath the RPE with a slice thickness of 20 mu m was best for delineating drusen on the images. The quantification of drusen on en-face OCT images showed good similarity to the standardised drusen analysis on fundus photography, making it easier to assess other changes in early and intermediate AMD.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Article
Ophthalmology
Matthias Gutfleisch, Oliver Ester, Soekmen Aydin, Martin Quassowski, Georg Spital, Albrecht Lommatzsch, Kai Rothaus, Adam Michael Dubis, Daniel Pauleikhoff
Summary: This study aims to develop convolutional neural networks (CNN) that can differentiate treatment indicated presentations of neovascular AMD (nAMD) based solely on SD-OCT scans. The results show that the developed AI algorithms have a high correlation with expert opinion and can provide diagnostic judgments on whether AMD needs treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Henrik Faatz, Kai Rothaus, Martin Ziegler, Marius Book, Georg Spital, Britta Heimes-Bussmann, Daniel Pauleikhoff, Albrecht Lommatzsch
Summary: The purpose of this study was to investigate the association between the vascular architecture of untreated macular neovascularisations (MNV) in neovascular age-related macular degeneration (nAMD) as visualized by optic coherence tomography angiography (OCTA) and the functional and morphological alterations of the retina as visualized by optic coherence tomography (SD-OCT). The study included 107 patients with newly diagnosed nAMD, and automated quantitative vascular analysis was performed. The results showed that BCVA was significantly worse with greater MNV area and total vascular length. Fluid distribution differed significantly in relation to MNV area, total vascular length, and fractal dimension. Greater pigment epithelial detachment (PED) height was significantly associated with higher density of vascular nodes and lower average vascular width. Atrophy was present significantly more often in MNV with larger area, higher total vascular length, and higher flow density. There was no significant association between MNV parameters and central retinal thickness or the occurrence of haemorrhage.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Julian Johannes Kuhlmann, Kai Rothaus, Xiaoyi Jiang, Britta Heimes-Bussmann, Henrik Faatz, Marius Book, Daniel Pauleikhoff
Summary: The purpose of this study is to describe and quantify the nonpathological axial stretching in the retinal vascular plexus in 3D optical coherence tomography angiography (OCTA) images. The vessels in the OCTA images were found to be stretched in the direction of the A-Scan by a factor of 2.46 +/- 1.82, with a larger cross-section area resulting in higher axial stretching. The elliptical shape of the vessel's cross-section was found to deviate from the expected pathology of the vascular network in the human eye, suggesting the need for volume data correction before 3D analysis.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Claus von der Burchard, Helge Sudkamp, Jan Tode, Cristoph Ehlken, Konstantine Purtskhvanidze, Moritz Moltmann, Britta Heimes, Peter Koch, Michael Muenst, Malte Vom Endt, Timo Kepp, Dirk Theisen-Kunde, Inke Koenig, Gereon Huettmann, Johann Roider
Summary: SELFF-OCT is a novel OCT technology designed for home monitoring of neovascular age-related macular degeneration (AMD). It has been successfully used for retinal self-examination in most patients, and could potentially become a valuable tool for retinal home monitoring in the future.
Article
Ophthalmology
C. Lommatzsch, P. Bauermann, B. Heimes-Bussmann, C. Nolte, C. Heinz
Summary: This study used OCTA to measure VD in uveitic eyes with secondary glaucoma, and found that VD in the UG group was significantly lower compared to the UV and HY groups. In the macular area, the superficial VD was also significantly lower in the UG group compared to the healthy group.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Ophthalmology
Henrik Faatz, Kai Rothaus, Martin Ziegler, Marius Book, Claudia Lommatzsch, Georg Spital, Matthias Gutfleisch, Daniel Pauleikhoff, Albrecht Lonnnnatzsch
CLINICAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Henrik Faatz, Marie-Louise Farecki, Kai Rothaus, Matthias Gutfleisch, Daniel Pauleikhoff, Albrecht Lommatzsch
BMJ OPEN OPHTHALMOLOGY
(2019)
