The role of endoglin in kidney fibrosis

ALK1 heterozygosity increases extracellular matrix protein expression, proliferation and migration in fibroblasts

(2014) José M. Muñoz-Félix et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular Pathways: Can Activin-like Kinase Pathway Inhibition Enhance the Limited Efficacy of VEGF Inhibitors?

(2014) R. S. Bhatt et al.   CLINICAL CANCER RESEARCH

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

The ALK-1/Smad1 pathway in cardiovascular physiopathology. A new target for therapy?

(2013) María González-Núñez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy

(2013) Yhun Yhong Sheen et al.   Biomolecules & Therapeutics

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

(2013) S. Levet et al.   BLOOD

ALK1-Smad1/5 signaling pathway in fibrosis development: Friend or foe?

(2013) José M. Muñoz-Félix et al.   CYTOKINE & GROWTH FACTOR REVIEWS

BMP-7 counteracting TGF-beta1 activities in organ fibrosis

(2013) Ralf Weiskirchen   Frontiers in Bioscience-Landmark

Unilateral ureteral obstruction: beyond obstruction

(2013) Alvaro C. Ucero et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Impaired Wound Repair in Adult Endoglin Heterozygous Mice Associated with Lower NO Bioavailability

(2013) Eduardo Pérez-Gómez et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Expression of fibrosis-related genes in human renal allografts with interstitial fibrosis and tubular atrophy

(2013) Aline L. Nogare et al.   JOURNAL OF NEPHROLOGY

Heterozygous disruption of activin receptor–like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy

(2013) José M. Muñoz-Félix et al.   KIDNEY INTERNATIONAL

Transforming growth factor-  and the progression of renal disease

(2013) I. Loeffler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice

(2013) Marion Scharpfenecker et al.   RADIOTHERAPY AND ONCOLOGY

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

(2012) N. Ricard et al.   BLOOD

Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration

(2012) E. Rossi et al.   BLOOD

Reduced Endoglin Activity Limits Cardiac Fibrosis and Improves Survival in Heart Failure

(2012) Navin K. Kapur et al.   CIRCULATION

Role of the TGF-β/BMP-7/Smad pathways in renal diseases

(2012) Xiao-Ming Meng et al.   CLINICAL SCIENCE

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lifetime Risk of ESRD

(2012) T. C. Turin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The renal (myo-)fibroblast: a heterogeneous group of cells

(2012) P. Boor et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The TGF-β co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney

(2012) Marion Scharpfenecker et al.   RADIOTHERAPY AND ONCOLOGY

Notice

(2012)   Kidney International Supplements

Alternative splicing factor or splicing factor-2 plays a key role in intron retention of the endoglin gene during endothelial senescence

(2011) Francisco J. Blanco et al.   AGING CELL

Platelet TGF- 1 contributions to plasma TGF- 1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

(2011) A. Meyer et al.   BLOOD

Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients

(2011) Ana M Blázquez-Medela et al.   BMC Medicine

Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects

(2011) Francisco J. López-Hernández et al.   CELL AND TISSUE RESEARCH

Hypoxia-inducible factor signaling in the development of tissue fibrosis

(2011) Debra F. Higgins et al.   CELL CYCLE

Exploring anti-TGF-β therapies in cancer and fibrosis

(2011) Lukas J. A. C. Hawinkels et al.   GROWTH FACTORS

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

(2011) Roselyne Castonguay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

(2011) Erin Morris et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications

(2011) José M López-Novoa et al.   Journal of Translational Medicine

The BMP-7–Smad1/5/8 Pathway Promotes Kidney Repair After Obstruction Induced Renal Injury

(2011) Scott R. Manson et al.   JOURNAL OF UROLOGY

ALK1 heterozygosity delays development of late normal tissue damage in the irradiated mouse kidney

(2011) Marion Scharpfenecker et al.   RADIOTHERAPY AND ONCOLOGY

The Role of the TGF-β Coreceptor Endoglin in Cancer

(2011) Eduardo Pérez-Gómez et al.   TheScientificWorldJOURNAL

Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin

(2011) Alan M. Holmes et al.   Journal of Cell Communication and Signaling

The physiological role of endoglin in the cardiovascular system

(2010) José M. López-Novoa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endoglin negatively regulates transforming growth factor β1-induced profibrotic responses in intestinal fibroblasts

(2010) J. P. Burke et al.   BRITISH JOURNAL OF SURGERY

Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis

(2010) L. J. A. C. Hawinkels et al.   CANCER RESEARCH

Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling

(2010) Steffen K. Meurer et al.   CELLULAR SIGNALLING

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

(2010) Marwa Mahmoud et al.   CIRCULATION RESEARCH

BMP-7 as antagonist of organ fibrosis

(2010) Ralf Weiskirchen   Frontiers in Bioscience-Landmark

Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy

(2010) María T Grande et al.   Journal of Inflammation-London

Resolved: EMT Produces Fibroblasts in the Kidney

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease

(2010) Omar García-Sánchez et al.   KIDNEY INTERNATIONAL

Endoglin differentially regulates TGF-β-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes

(2010) K.W. Finnson et al.   OSTEOARTHRITIS AND CARTILAGE

Endoglin-Targeted Cancer Therapy

(2010) Ben K. Seon et al.   Current Drug Delivery

The emerging role of TGF-β superfamily coreceptors in cancer

(2009) Carmelo Bernabeu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration

(2009) Bridgette N. Ray et al.   CARCINOGENESIS

Regression of diabetic complications by islet transplantation in the rat

(2009) A. Remuzzi et al.   DIABETOLOGIA

Anti-endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature

(2009) Shima Uneda et al.   INTERNATIONAL JOURNAL OF CANCER

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Fibroblast activation and myofibroblast generation in obstructive nephropathy

(2009) María T. Grande et al.   Nature Reviews Nephrology

Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys

(2009) Marion Scharpfenecker et al.   RADIOTHERAPY AND ONCOLOGY

Endoglin in angiogenesis and vascular diseases

(2008) Peter ten Dijke et al.   ANGIOGENESIS

TGF-β regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3–Sp1–KLF6 interaction

(2008) Luisa M. Botella et al.   BIOCHEMICAL JOURNAL

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Endoglin Promotes Transforming Growth Factor β-mediated Smad 1/5/8 Signaling and Inhibits Endothelial Cell Migration through Its Association with GIPC

(2008) Nam Y. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALK1 Opposes ALK5/Smad3 Signaling and Expression of Extracellular Matrix Components in Human Chondrocytes

(2008) Kenneth W Finnson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

L- and S-endoglin differentially modulate TGF 1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts

(2008) S. Velasco et al.   JOURNAL OF CELL SCIENCE

Identification of serum endoglin as a novel prognostic marker after acute myocardial infarction

(2008) Ignacio Cruz-Gonzalez et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Expression of fibrosis-associated molecules in IgA nephropathy treated with cyclosporine

(2008) Beom Jin Lim et al.   PEDIATRIC NEPHROLOGY

Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease

(2008) Michael Zeisberg et al.   PEDIATRIC NEPHROLOGY

Placental Productions and Expressions of Soluble Endoglin, Soluble fms-Like Tyrosine Kinase Receptor-1, and Placental Growth Factor in Normal and Preeclamptic Pregnancies

(2007) Yang Gu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM