Epigenetic mechanisms regulating normal and malignant haematopoiesis: new therapeutic targets for clinical medicine

Genome-Wide Views of Chromatin Structure

(2009) Oliver J. Rando et al.   Annual Review of Biochemistry

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

(2009) M. Hoogenkamp et al.   BLOOD

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

(2009) R. Garzon et al.   BLOOD

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies

(2009) T. E. Fandy et al.   BLOOD

Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-Initiating Cells in C/EBPα Mutant AML

(2009) Oxana Bereshchenko et al.   CANCER CELL

Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation

(2009) H. P. Mohammad et al.   CANCER RESEARCH

Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies

(2009) Susumu Goyama et al.   CANCER SCIENCE

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

MicroRNA Control in the Immune System: Basic Principles

(2009) Changchun Xiao et al.   CELL

Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

(2009) Marina Chekulaeva et al.   CURRENT OPINION IN CELL BIOLOGY

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

The molecular biology of mixed lineage leukemia

(2009) R. K. Slany   HAEMATOLOGICA

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

(2009) Pierre Fenaux et al.   LANCET ONCOLOGY

Chromatin maps, histone modifications and leukemia

(2009) T Neff et al.   LEUKEMIA

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

(2009) C Flotho et al.   LEUKEMIA

MicroRNAs in the ontogeny of leukemias and lymphomas

(2009) Muller Fabbri et al.   LEUKEMIA & LYMPHOMA

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

(2009) Ann-Marie Bröske et al.   NATURE GENETICS

Developmental programming of CpG island methylation profiles in the human genome

(2009) Ravid Straussman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis

(2009) Stefan Glaser et al.   Epigenetics & Chromatin

Translation of the Philadelphia chromosome into therapy for CML

(2008) B. J. Druker   BLOOD

Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

(2008) M. Heuser et al.   BLOOD

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Multiple copies of RUNX1: description of 14 new patients, follow-up, and a review of the literature

(2008) Patricia Pérez-Vera et al.   CANCER GENETICS AND CYTOGENETICS

Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells

(2008) Susumu Goyama et al.   Cell Stem Cell

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

(2008) M. G. Guenther et al.   GENES & DEVELOPMENT

5-Azacitidine has limited therapeutic activity in myelofibrosis

(2008) R A Mesa et al.   LEUKEMIA

A phase II study of 5-azacitidine for patients with primary and post-essential thrombocythemia/polycythemia vera myelofibrosis

(2008) A Quintás-Cardama et al.   LEUKEMIA

Concurrent methylation of promoters from tumor associated genes predicts outcome in acute myeloid leukemia

(2008) Corine J. Hess et al.   LEUKEMIA & LYMPHOMA

MiR-15a and miR-16-1 cluster functions in human leukemia

(2008) George A. Calin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene regulatory networks directing myeloid and lymphoid cell fates within the immune system

(2008) Peter Laslo et al.   SEMINARS IN IMMUNOLOGY

The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development

(2007) C. T. Griffin et al.   DEVELOPMENT

Nucleosome destabilization in the epigenetic regulation of gene expression

(2007) Steven Henikoff   NATURE REVIEWS GENETICS