Pre-erythrocytic malaria vaccines: identifying the targets

Plasmodium yoelii Macrophage Migration Inhibitory Factor Is Necessary for Efficient Liver-Stage Development

(2012) Jessica L. Miller et al.   INFECTION AND IMMUNITY

Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector

(2012) Geraldine A. O’Hara et al.   JOURNAL OF INFECTIOUS DISEASES

Protective CD8+ T lymphocytes in Primates Immunized with Malaria Sporozoites

(2012) Walter R. Weiss et al.   PLoS One

Host cell invasion by apicomplexans: what do we know?

(2012) Daniel Bargieri et al.   TRENDS IN PARASITOLOGY

Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates

(2012) Takeshi Annoura et al.   VACCINE

Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte

(2011) David T. Riglar et al.   Cell Host & Microbe

Independent Roles of Apical Membrane Antigen 1 and Rhoptry Neck Proteins during Host Cell Invasion by Apicomplexa

(2011) Donatella Giovannini et al.   Cell Host & Microbe

Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

(2011) Noah S. Butler et al.   Cell Host & Microbe

Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites

(2011) Sebastian A. Mikolajczak et al.   CELLULAR MICROBIOLOGY

Novel Strategies to Improve DNA Vaccine Immunogenicity

(2011) Cevayir Coban et al.   CURRENT GENE THERAPY

Early Transcriptional Responses of HepG2-A16 Liver Cells to Infection byPlasmodium falciparumSporozoites

(2011) Rana Chattopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host

(2011) Alida Coppi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study

(2011) Meta Roestenberg et al.   LANCET

Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5–17 months in Kenya and Tanzania: a randomised controlled trial

(2011) Ally Olotu et al.   LANCET INFECTIOUS DISEASES

Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates

(2011) Keith Limbach et al.   MALARIA JOURNAL

Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites

(2011) Joana M. Haussig et al.   MOLECULAR MICROBIOLOGY

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Induction of Plasmodium falciparum-Specific CD4+ T Cells and Memory B Cells in Gabonese Children Vaccinated with RTS,S/AS01E and RTS,S/AS02D

(2011) Selidji T. Agnandji et al.   PLoS One

Virosome-Formulated Plasmodium falciparum AMA-1 & CSP Derived Peptides as Malaria Vaccine: Randomized Phase 1b Trial in Semi-Immune Adults & Children

(2011) Patrick Georges Cech et al.   PLoS One

Circumsporozoite-Specific T Cell Responses in Children Vaccinated with RTS,S/AS01E and Protection against P falciparum Clinical Malaria

(2011) Ally Olotu et al.   PLoS One

Evaluation of Approaches to Identify the Targets of Cellular Immunity on a Proteome-Wide Scale

(2011) Fernanda C. Cardoso et al.   PLoS One

Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults

(2011) Martha Sedegah et al.   PLoS One

Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

(2011) Cindy Tamminga et al.   PLoS One

Revealing a Parasite's Invasive Trick

(2011) J. Baum et al.   SCIENCE

Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites

(2011) Satish Mishra et al.   VACCINE

Plasmodium Protease ROM1 Is Important for Proper Formation of the Parasitophorous Vacuole

(2011) Iset Medina Vera et al.   PLoS Pathogens

Longevity and Composition of Cellular Immune Responses Following Experimental Plasmodium falciparum Malaria Infection in Humans

(2011) Anne C. Teirlinck et al.   PLoS Pathogens

Hostile Takeover by Plasmodium: Reorganization of Parasite and Host Cell Membranes during Liver Stage Egress

(2011) Stefanie Graewe et al.   PLoS Pathogens

The Th1 Immune Response to Plasmodium falciparum Circumsporozoite Protein Is Boosted by Adenovirus Vectors 35 and 26 with a Homologous Insert

(2010) K. Radosevic et al.   Clinical and Vaccine Immunology

Minimal Role for the Circumsporozoite Protein in the Induction of Sterile Immunity by Vaccination with Live Rodent Malaria Sporozoites

(2010) M. Mauduit et al.   INFECTION AND IMMUNITY

Plasmodiumpyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection

(2010) Ying Pei et al.   MOLECULAR MICROBIOLOGY

Transcriptional Analysis of the Pre-Erythrocytic Stages of the Rodent Malaria Parasite, Plasmodium yoelii

(2010) Calvin T. Williams et al.   PLoS One

Immunization with Pre-Erythrocytic Antigen CelTOS from Plasmodium falciparum Elicits Cross-Species Protection against Heterologous Challenge with Plasmodium berghei

(2010) Elke S Bergmann-Leitner et al.   PLoS One

Development of the malaria parasite in the skin of the mammalian host

(2010) P. Gueirard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

(2010) Nathan W. Schmidt et al.   PLoS Pathogens

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

(2009) Sónia S Albuquerque et al.   BMC GENOMICS

Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1 Induce Antibody- and T Cell-Mediated Multistage Protection against Malaria

(2009) Simon J. Draper et al.   Cell Host & Microbe

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

(2009) Russell E. Vance et al.   Cell Host & Microbe

LISP1 is important for the egress ofPlasmodium bergheiparasites from liver cells

(2009) Tomoko Ishino et al.   CELLULAR MICROBIOLOGY

Plasmodium sporozoite–host interactions from the dermis to the hepatocyte

(2009) Ijeoma Ejigiri et al.   CURRENT OPINION IN MICROBIOLOGY

Role of Plasmodium berghei cGMP-dependent Protein Kinase in Late Liver Stage Development

(2009) Adebola Falae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinology in the genome era

(2009) C. Daniela Rinaudo et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetically Attenuated Parasite Vaccines Induce Contact-Dependent CD8+ T Cell Killing of Plasmodium yoelii Liver Stage-Infected Hepatocytes

(2009) A. Trimnell et al.   JOURNAL OF IMMUNOLOGY

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Adjuvants for malaria vaccines

(2009) R. N. COLER et al.   PARASITE IMMUNOLOGY

Antigens for pre-erythrocytic malaria vaccines: building on success

(2009) C. SPEAKE et al.   PARASITE IMMUNOLOGY

Conserved Protective Mechanisms in Radiation and Genetically Attenuated uis3(-) and uis4(-) Plasmodium Sporozoites

(2009) Kota Arun Kumar et al.   PLoS One

A Randomized Trial Assessing the Safety and Immunogenicity of AS01 and AS02 Adjuvanted RTS,S Malaria Vaccine Candidates in Children in Gabon

(2009) Bertrand Lell et al.   PLoS One

A Role for Immune Responses against Non-CS Components in the Cross-Species Protection Induced by Immunization with Irradiated Malaria Sporozoites

(2009) Marjorie Mauduit et al.   PLoS One

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

(2009) K. M. VanBuskirk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

(2009) James F. Cummings et al.   VACCINE

Assessment and improvement of the Plasmodium yoelii yoelii genome annotation through comparative analysis

(2008) Ashley Vaughan et al.   BIOINFORMATICS

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

(2008) Min Yu et al.   Cell Host & Microbe

The Plasmodium TRAP/MIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites

(2008) Cristina K. Moreira et al.   CELLULAR MICROBIOLOGY

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

Contribution of influenza immunity and virosomal-formulated synthetic peptide to cellular immune responses in a phase I subunit malaria vaccine trial

(2008) Elisabetta Peduzzi et al.   CLINICAL IMMUNOLOGY

Functional Characterization of a RedundantPlasmodiumTRAP Family Invasin, TRAP-Like Protein, by Aldolase Binding and a Genetic Complementation Test

(2008) Kirsten Heiss et al.   EUKARYOTIC CELL

The skin stage of malaria infection: biology and relevance to the malaria vaccine effort

(2008) Photini Sinnis et al.   Future Microbiology

Impact of Recombinant Adenovirus Serotype 35 Priming versus Boosting of a Plasmodium falciparum Protein: Characterization of T- and B-Cell Responses to Liver-Stage Antigen 1

(2008) A. Rodriguez et al.   INFECTION AND IMMUNITY

Effector CD8+ T Lymphocytes against Liver Stages of Plasmodium yoelii Do Not Require Gamma Interferon for Antiparasite Activity

(2008) S. Chakravarty et al.   INFECTION AND IMMUNITY

TREP, a novel protein necessary for gliding motility of the malaria sporozoite

(2008) Audrey Combe et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

An efficient strategy for gene targeting and phenotypic assessment in the Plasmodium yoelii rodent malaria model

(2008) Sebastian A. Mikolajczak et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Distinct Malaria Parasite Sporozoites Reveal Transcriptional Changes That Cause Differential Tissue Infection Competence in the Mosquito Vector and Mammalian Host

(2008) S. A. Mikolajczak et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeted deletion ofSAP1abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection

(2008) Ahmed S. I. Aly et al.   MOLECULAR MICROBIOLOGY

Evidence-Based Annotation of the Malaria Parasite's Genome Using Comparative Expression Profiling

(2008) Yingyao Zhou et al.   PLoS One

Phase 1 Trial of Malaria Transmission Blocking Vaccine Candidates Pfs25 and Pvs25 Formulated with Montanide ISA 51

(2008) Yimin Wu et al.   PLoS One

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

(2008) N. W. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A combined transcriptome and proteome survey of malaria parasite liver stages

(2008) A. S. Tarun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

No TRAP, no invasion

(2008) Belinda J. Morahan et al.   TRENDS IN PARASITOLOGY

Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research

(2008) Kent E. Kester et al.   VACCINE

Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice

(2008) Andreas Wack et al.   VACCINE

A Sporozoite Asparagine-Rich Protein Controls Initiation of Plasmodium Liver Stage Development

(2008) Olivier Silvie et al.   PLoS Pathogens

Temperature Shift and Host Cell Contact Up-Regulate Sporozoite Expression of Plasmodium falciparum Genes Involved in Hepatocyte Infection

(2008) Anthony Siau et al.   PLoS Pathogens

Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity

(2008) Edwin Lasonder et al.   PLoS Pathogens