The challenge of developing a herpes simplex virus 2 vaccine

A Herpes Simplex Virus 2 Glycoprotein D Mutant Generated by Bacterial Artificial Chromosome Mutagenesis Is Severely Impaired for Infecting Neuronal Cells and Infects Only Vero Cells Expressing Exogenous HVEM

(2012) K. Wang et al.   JOURNAL OF VIROLOGY

Live Attenuated Herpes Simplex Virus 2 Glycoprotein E Deletion Mutant as a Vaccine Candidate Defective in Neuronal Spread

(2012) Sita Awasthi et al.   JOURNAL OF VIROLOGY

Efficacy Results of a Trial of a Herpes Simplex Vaccine

(2012) Robert B. Belshe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sustained immunogenicity and efficacy of the HPV-16/18 AS04-adjuvanted vaccine

(2012) Cecilia M. Roteli-Martins et al.   Human Vaccines & Immunotherapeutics

Severe Viral Infections and Primary Immunodeficiencies

(2011) L. K. Dropulic et al.   CLINICAL INFECTIOUS DISEASES

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

A Murine Genital-Challenge Model Is a Sensitive Measure of Protective Antibodies against Human Papillomavirus Infection

(2011) S. Longet et al.   JOURNAL OF VIROLOGY

Immunization with Herpes Simplex Virus 2 (HSV-2) Genes plus Inactivated HSV-2 Is Highly Protective against Acute and Recurrent HSV-2 Disease

(2011) C. S. Morello et al.   JOURNAL OF VIROLOGY

Immunization with a Vaccine Combining Herpes Simplex Virus 2 (HSV-2) Glycoprotein C (gC) and gD Subunits Improves the Protection of Dorsal Root Ganglia in Mice and Reduces the Frequency of Recurrent Vaginal Shedding of HSV-2 DNA in Guinea Pigs Compared to Immunization with gD Alone

(2011) S. Awasthi et al.   JOURNAL OF VIROLOGY

A Live-Attenuated HSV-2 ICP0− Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine

(2011) William P. Halford et al.   PLoS One

Safety and immunogenicity of long HSV-2 peptides complexed with rhHsc70 in HSV-2 seropositive persons

(2011) Anna Wald et al.   VACCINE

Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs

(2010) Richard Brans et al.   BMC MICROBIOLOGY

Diversity in CD8+ T Cell Function and Epitope Breadth Among Persons with Genital Herpes

(2010) Kerry J. Laing et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Detailed Characterization of T Cell Responses to Herpes Simplex Virus-2 in Immune Seronegative Persons

(2010) C. M. Posavad et al.   JOURNAL OF IMMUNOLOGY

Sequence Variability in Clinical and Laboratory Isolates of Herpes Simplex Virus 1 Reveals New Mutations

(2010) M. L. Szpara et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 2 ICP0− Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine

(2010) William P. Halford et al.   PLoS One

Herpes simplex virus type 2 glycoprotein E is required for efficient virus spread from epithelial cells to neurons and for targeting viral proteins from the neuron cell body into axons

(2010) Fushan Wang et al.   VIROLOGY

Protection from Herpes Simplex Virus (HSV)–2 Infection with Replication‐Defective HSV‐2 or Glycoprotein D2 Vaccines in HSV‐1–Seropositive and HSV‐1–Seronegative Guinea Pigs

(2009) Yo Hoshino et al.   JOURNAL OF INFECTIOUS DISEASES

Prevention of Genital Herpes Simplex Virus Type 1 and 2 Disease in Mice Immunized with a gD-Expressing Dominant-Negative Recombinant HSV-1

(2009) Richard Brans et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Macaque Model to Study Vaginal HSV-2/Immunodeficiency Virus Co-Infection and the Impact of HSV-2 on Microbicide Efficacy

(2009) Federica Crostarosa et al.   PLoS One

The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding

(2009) R. C. Kines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection

(2008) Katharine Looker   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Phase I Study of a Herpes Simplex Virus Type 2 (HSV-2) DNA Vaccine Administered to Healthy, HSV-2-Seronegative Adults by a Needle-Free Injection System

(2008) A. Cattamanchi et al.   Clinical and Vaccine Immunology

Rapidly Cleared Episodes of Herpes Simplex Virus Reactivation in Immunocompetent Adults

(2008) Karen E. Mark et al.   JOURNAL OF INFECTIOUS DISEASES

High-Level Expression of Glycoprotein D by a Dominant-Negative HSV-1 Virus Augments its Efficacy as a Vaccine against HSV-1 Infection

(2008) Zheming Lu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Virus-Encoded B7-2 Costimulation Molecules Enhance the Protective Capacity of a Replication-Defective Herpes Simplex Virus Type 2 Vaccine in Immunocompetent Mice

(2008) S. P. Vagvala et al.   JOURNAL OF VIROLOGY

Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs

(2008) Yo Hoshino et al.   VACCINE

An HSV-1 gD mutant virus as an entry-impaired live virus vaccine

(2008) Sita Awasthi et al.   VACCINE