Journal
EXPERT REVIEW OF VACCINES
Volume 11, Issue 12, Pages 1441-1457Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.12.117
Keywords
dendritic cell subsets and maturation; innate and adaptive immunity; respiratory syncytial virus; vaccine
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Krembil Foundation
- Bill and Melinda Gates Foundation
- Saskatchewan Agriculture, Food and Rural Revitalization
- Alberta Livestock and Meat Agency
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Expert Rev. Vaccines 11(12), 1441-1457 (2012) Respiratory syncytial virus (RSV) is a common human pathogen that causes cold-like symptoms in most healthy adults and children. However, RSV often moves into the lower respiratory tract in infants and young children predisposed to respiratory illness, making it the most common cause of pediatric broncheolitis and pneumonia. The development of an appropriate balanced immune response is critical for recovery from RSV, while an unbalanced and/or excessively vigorous response may lead to immunopathogenesis. Different dendritic cell (DC) subsets influence the magnitude and quality of the host response to RSV infection, with myeloid DCs mediating and plasmacytoid DCs modulating immunopathology. Furthermore, stimulation of DCs through Toll-like receptors is essential for induction of protective immunity to RSV. These characteristics have implications for the rational design of a RSV vaccine.
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