Cationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status

Comparison of BCG, MPL and cationic liposome adjuvant systems in leishmanial antigen vaccine formulations against murine visceral leishmaniasis

(2012) Rajesh Ravindran et al.   BMC MICROBIOLOGY

Chlamydia muridarum T Cell Antigens and Adjuvants That Induce Protective Immunity in Mice

(2012) Hong Yu et al.   INFECTION AND IMMUNITY

Breaking B and T cell tolerance using cationic lipid–DNA complexes (CLDC) as a vaccine adjuvant with hepatitis B virus (HBV) surface antigen in transgenic mice expressing HBV

(2011) John D. Morrey et al.   ANTIVIRAL RESEARCH

Enantiospecific adjuvant activity of cationic lipid DOTAP in cancer vaccine

(2011) Elizabeth A. Vasievich et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cationic liposomes as vaccine adjuvants

(2011) Dennis Christensen et al.   Expert Review of Vaccines

Dendritic Cells Prevent Rather Than Promote Immunity Conferred by a Helicobacter Vaccine Using a Mycobacterial Adjuvant

(2011) Iris Hitzler et al.   GASTROENTEROLOGY

Adjuvant effect of cationic liposomes and CpG depends on administration route

(2011) Bram Slütter et al.   JOURNAL OF CONTROLLED RELEASE

Pegylation of DDA:TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responses

(2011) Randip Kaur et al.   JOURNAL OF CONTROLLED RELEASE

Vaccination with Liposomal Leishmanial Antigens Adjuvanted with Monophosphoryl Lipid–Trehalose Dicorynomycolate (MPL-TDM) Confers Long-Term Protection against Visceral Leishmaniasis through a Human Administrable Route

(2011) Rajesh Ravindran et al.   MOLECULAR PHARMACEUTICS

CAF01 Potentiates Immune Responses and Efficacy of an Inactivated Influenza Vaccine in Ferrets

(2011) Cyril Jean-Marie Martel et al.   PLoS One

Immunogenicity and Protective Efficacy of a Fusion Protein Vaccine Consisting of Antigen Ag85B and HspX against Mycobacterium tuberculosis Infection in Mice

(2011) Q. Li et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity

(2011) Angela Henderson et al.   VACCINE

Construction and evaluation of a multistage Mycobacterium tuberculosis subunit vaccine candidate Mtb10.4–HspX

(2011) Hongxia Niu et al.   VACCINE

Development and preclinical safety evaluation of a new therapeutic HIV-1 vaccine based on 18 T-cell minimal epitope peptides applying a novel cationic adjuvant CAF01

(2011) Anders Fomsgaard et al.   VACCINE

Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig

(2011) David I. Bernstein et al.   VACCINE

Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes

(2011) Ida Rosenkrands et al.   VACCINE

A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). II. Studies in mice and ferrets and mechanism of adjuvanticity

(2011) Orli Even-Or et al.   VACCINE

Cationic liposome–DNA complexes (CLDC) adjuvant enhances the immunogenicity and cross-protective efficacy of a pre-pandemic influenza A H5N1 vaccine in mice

(2011) Libo Dong et al.   VACCINE

Immunogenicity and protective efficacy of a vaxfectin-adjuvanted tetravalent dengue DNA vaccine

(2011) Kevin R. Porter et al.   VACCINE

Potentiating Effects of MPL on DSPC Bearing Cationic Liposomes Promote Recombinant GP63 Vaccine Efficacy: High Immunogenicity and Protection

(2011) Saumyabrata Mazumder et al.   PLoS Neglected Tropical Diseases

Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo

(2010) Pernille Nordly et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

Chlamydia muridarum T-Cell Antigens Formulated with the Adjuvant DDA/TDB Induce Immunity against Infection That Correlates with a High Frequency of Gamma Interferon (IFN- )/Tumor Necrosis Factor Alpha and IFN- /Interleukin-17 Double-Positive CD4+ T Cells

(2010) H. Yu et al.   INFECTION AND IMMUNITY

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

(2010) Deepa Mohanan et al.   JOURNAL OF CONTROLLED RELEASE

Lympho-geographical concepts in vaccine delivery

(2010) Pål Johansen et al.   JOURNAL OF CONTROLLED RELEASE

Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response

(2010) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Immunity by formulation design: Induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method

(2010) Pernille Nordly et al.   JOURNAL OF CONTROLLED RELEASE

Subunit Vaccines: Distearoylphosphatidylcholine-Based Liposomes Entrapping Antigen Offer a Neutral Alternative to Dimethyldioctadecylammonium-Based Cationic Liposomes as an Adjuvant Delivery System

(2010) Sarah E. McNeil et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cationic Lipid/DNA Complex-Adjuvanted Influenza A Virus Vaccination Induces Robust Cross-Protective Immunity

(2010) D. K. Hong et al.   JOURNAL OF VIROLOGY

Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3β-[N-(N′,N′-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome Retention Mediates Stronger Th1 Responses

(2010) Malou Henriksen-Lacey et al.   MOLECULAR PHARMACEUTICS

Protection against Chlamydia Promoted by a Subunit Vaccine (CTH1) Compared with a Primary Intranasal Infection in a Mouse Genital Challenge Model

(2010) Anja Weinreich Olsen et al.   PLoS One

Syringe Free Vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles Provides Strong and Prolonged Protection Against Tuberculosis

(2010) Dennis Christensen et al.   PLoS One

Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine

(2010) Orli Even-Or et al.   VACCINE

Embryo vaccination of chickens using a novel adjuvant formulation stimulates protective immunity against Eimeria maxima infection

(2010) Sung-Hyen Lee et al.   VACCINE

Protection against pneumonic plague following oral immunization with a non-replicating vaccine

(2010) Abby Jones et al.   VACCINE

Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin

(2010) Larry R. Smith et al.   VACCINE

Evaluation of three experimental bovine viral diarrhea virus killed vaccines adjuvanted with combinations of Quil A cholesterol and dimethyldioctadecylammonium (DDA) bromide

(2010) Julia F. Ridpath et al.   VETERINARY RESEARCH COMMUNICATIONS

A novel vaccine adjuvant for recombinant flu antigens

(2009) Stella Chang et al.   BIOLOGICALS

Fusogenic activity of cationic lipids and lipid shape distribution

(2009) Caroline Lonez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Potent Adjuvant Activity of Cationic Liposome-DNA Complexes for Genital Herpes Vaccines

(2009) D. I. Bernstein et al.   Clinical and Vaccine Immunology

Transcutaneous immunization by lipoplex-patch based DNA vaccines is effective vaccination against Japanese encephalitis virus infection

(2009) Jing-Yan Cheng et al.   JOURNAL OF CONTROLLED RELEASE

Comparison of liposome based antigen delivery systems for protection against Leishmania donovani

(2009) Swati Bhowmick et al.   JOURNAL OF CONTROLLED RELEASE

Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen

(2009) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Novel Generation Mycobacterial Adjuvant Based on Liposome-Encapsulated Monomycoloyl Glycerol from Mycobacterium bovis Bacillus Calmette-Guerin

(2009) C. A. S. Andersen et al.   JOURNAL OF IMMUNOLOGY

Quality and Vaccine Efficacy of CD4+ T Cell Responses Directed to Dominant and Subdominant Epitopes in ESAT-6 from Mycobacterium tuberculosis

(2009) C. S. Aagaard et al.   JOURNAL OF IMMUNOLOGY

Tuberculosis Subunit Vaccination Provides Long-Term Protective Immunity Characterized by Multifunctional CD4 Memory T Cells

(2009) T. Lindenstrom et al.   JOURNAL OF IMMUNOLOGY

Rapid immunity to vaccination with woodchuck hepatitis virus surface antigen using cationic liposome-DNA complexes as adjuvant

(2009) Paul J. Cote et al.   JOURNAL OF MEDICAL VIROLOGY

Protective effect of DNA-mediated immunization with liposome-encapsulated GRA4 against infection of Toxoplasma gondii

(2009) Rui Chen et al.   Journal of Zhejiang University-SCIENCE B

Identification of Novel Leishmania donovani Antigens that Help Define Correlates of Vaccine-Mediated Protection in Visceral Leishmaniasis

(2009) Sudipta Bhowmick et al.   PLoS One

A Liposome-Based Mycobacterial Vaccine Induces Potent Adult and Neonatal Multifunctional T Cells through the Exquisite Targeting of Dendritic Cells

(2009) Arun T. Kamath et al.   PLoS One

Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone®) increases antibody response, cellular immunity, and antigenically drifted protection

(2009) Marla Lay et al.   VACCINE

Fusion protein Ag85B-MPT64190–198-Mtb8.4 has higher immunogenicity than Ag85B with capacity to boost BCG-primed immunity against Mycobacterium tuberculosis in mice

(2009) Yu Luo et al.   VACCINE

The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs

(2009) David I. Bernstein et al.   VACCINE

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes

(2008) Rogério S Rosada et al.   BMC IMMUNOLOGY

Enhanced Protection against Bovine Tuberculosis after Coadministration of Mycobacterium bovis BCG with a Mycobacterial Protein Vaccine-Adjuvant Combination but Not after Coadministration of Adjuvant Alone

(2008) D. N. Wedlock et al.   Clinical and Vaccine Immunology

Use of Vaxfectin Adjuvant with DNA Vaccine Encoding the Measles Virus Hemagglutinin and Fusion Proteins Protects Juvenile and Infant Rhesus Macaques against Measles Virus

(2008) C.-H. Pan et al.   Clinical and Vaccine Immunology

DiC14-amidine cationic liposomes stimulate myeloid dendritic cells through Toll-like receptor 4

(2008) Tetsuya Tanaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

gp63 in Stable Cationic Liposomes Confers Sustained Vaccine Immunity to Susceptible BALB/c Mice Infected with Leishmania donovani

(2008) S. Bhowmick et al.   INFECTION AND IMMUNITY

The effects of salt on the physicochemical properties and immunogenicity of protein based vaccine formulated in cationic liposome

(2008) Weili Yan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Reactive oxygen species play a central role in the activity of cationic liposome based cancer vaccine

(2008) Weili Yan et al.   JOURNAL OF CONTROLLED RELEASE

Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres

(2008) Daniel J. Kirby et al.   JOURNAL OF DRUG TARGETING

Plasmid DNA–Based Vaccines Protect Mice and Ferrets against Lethal Challenge with A/Vietnam/1203/04 (H5N1) Influenza Virus

(2008) Peggy A. Lalor et al.   JOURNAL OF INFECTIOUS DISEASES

Liposome Delivery ofChlamydia muridarumMajor Outer Membrane Protein Primes a Th1 Response That Protects against Genital Chlamydial Infection in a Mouse Model1

(2008) Jon Hansen et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of Cytotoxic T-Lymphocytes and Antitumor Activity by a Liposomal Lipopeptide Vaccine

(2008) Weihsu Chen et al.   MOLECULAR PHARMACEUTICS

Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements

(2008) Else Marie Agger et al.   PLoS One

Evaluation of immune responses and protective efficacy in a goat model following immunization with a coctail of recombinant antigens and a polyprotein of Mycobacterium avium subsp. paratuberculosis

(2008) Kumanan Kathaperumal et al.   VACCINE

Phase I study of a candidate vaccine based on recombinant HIV-1 gp160 (MN/LAI) administered by the mucosal route to HIV-seronegative volunteers: The ANRS VAC14 study

(2007) Gilles Pialoux et al.   VACCINE