Strategies to overcome host immunity to adenovirus vectors in vaccine development

Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1

(2009) R. C. Carlisle et al.   BLOOD

Transient Pretreatment With Glucocorticoid Ablates Innate Toxicity of Systemically Delivered Adenoviral Vectors Without Reducing Efficacy

(2009) Sergey S Seregin et al.   MOLECULAR THERAPY

Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model

(2009) Anurag Sharma et al.   VIROLOGY

The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution

(2009) Elena Seiradake et al.   PLoS Pathogens

Regulation of antigen presentation machinery in human dendritic cells by recombinant adenovirus

(2008) Lazar Vujanovic et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Mechanism of Adenovirus Neutralization by Human α-Defensins

(2008) Jason G. Smith et al.   Cell Host & Microbe

Single-dose immunogenicity and protective efficacy of simian adenoviral vectors againstPlasmodium berghei

(2008) Arturo Reyes-Sandoval et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors

(2008) D M Appledorn et al.   GENE THERAPY

Adenovirus-Based Targeting in Myoblasts Is Hampered by Nonhomologous Vector Integration

(2008) Olga Isman et al.   HUMAN GENE THERAPY

Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells

(2008) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?

(2008) Rafick-Pierre Sekaly   JOURNAL OF EXPERIMENTAL MEDICINE

Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer

(2008) Nicola K. Green et al.   JOURNAL OF GENE MEDICINE

Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages

(2008) H. J. Haisma et al.   JOURNAL OF GENERAL VIROLOGY

Adenovirus DNA polymerase is recognized by human CD8+ T cells

(2008) A. Joshi et al.   JOURNAL OF GENERAL VIROLOGY

Single-Dose Protection against Plasmodium berghei by a Simian Adenovirus Vector Using a Human Cytomegalovirus Promoter Containing Intron A

(2008) S. Sridhar et al.   JOURNAL OF VIROLOGY

Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement

(2008) Z. Xu et al.   JOURNAL OF VIROLOGY

Host Immune Responses to Chronic Adenovirus Infections in Human and Nonhuman Primates

(2008) R. Calcedo et al.   JOURNAL OF VIROLOGY

Neutralizing Antibody Blocks Adenovirus Infection by Arresting Microtubule-Dependent Cytoplasmic Transport

(2008) J. G. Smith et al.   JOURNAL OF VIROLOGY

Magnitude and Phenotype of Cellular Immune Responses Elicited by Recombinant Adenovirus Vectors and Heterologous Prime-Boost Regimens in Rhesus Monkeys

(2008) J. Liu et al.   JOURNAL OF VIROLOGY

Modification of Adenoviral Vectors With Polyethylene Glycol Modulates In Vivo Tissue Tropism and Gene Expression

(2008) Sean E Hofherr et al.   MOLECULAR THERAPY

The Immunogenicity of Adenovirus Vectors Limits the Multispecificity of CD8 T-cell Responses to Vector-encoded Transgenic Antigens

(2008) Reinhold Schirmbeck et al.   MOLECULAR THERAPY

Substitution of Hexon Hypervariable Region 5 of Adenovirus Serotype 5 Abrogates Blood Factor Binding and Limits Gene Transfer to Liver

(2008) Frédéric Vigant et al.   MOLECULAR THERAPY

Bovine Adenoviral Vector–based H5N1 Influenza Vaccine Overcomes Exceptionally High Levels of Pre-existing Immunity Against Human Adenovirus

(2008) Neetu Singh et al.   MOLECULAR THERAPY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

(2008) Jinyan Liu et al.   NATURE

Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans

(2008) David I Watkins et al.   NATURE MEDICINE

Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice

(2008) Maria A. Croyle et al.   PLoS One

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

(2008) O. Kalyuzhniy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune barriers to successful gene therapy

(2008) Te-Lang Wu et al.   TRENDS IN MOLECULAR MEDICINE

Optimization of Capsid-Incorporated Antigens For A Novel Adenovirus Vaccine Approach

(2008) Qiana L Matthews et al.   Virology Journal

HIV Vaccine Development in the Aftermath of the STEP Study: Re-Focus on Occult HIV Infection?

(2008) Klaus Überla   PLoS Pathogens

Development of PEGylated adenovirus vector with targeting ligand

(2007) Yusuke Eto et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Innate immune response induced by gene delivery vectors

(2007) Haruna Sakurai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Converging Paths of Viral and Non-viral Vector Engineering

(2007) Ernst Wagner   MOLECULAR THERAPY

Vaccination Against Hepatitis C Virus With Dendritic Cells Transduced With an Adenovirus Encoding NS3 Protein

(2007) Aintzane Zabaleta et al.   MOLECULAR THERAPY

Fully Detargeted Polyethylene Glycol-coated Adenovirus Vectors Are Potent Genetic Vaccines and Escape from Pre-existing Anti-adenovirus Antibodies

(2007) Andreas Wortmann et al.   MOLECULAR THERAPY

Modification of Adenovirus Gene Transfer Vectors With Synthetic Polymers: A Scientific Review and Technical Guide

(2007) Florian Kreppel et al.   MOLECULAR THERAPY

Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications

(2007) Zachary C. Hartman et al.   VIRUS RESEARCH