Using proteomics to identify the HBx interactome in hepatitis B virus: how can this inform the clinic?

Unraveling the complexity of hepatitis B virus: From molecular understanding to therapeutic strategy in 50 years

(2013) Bo Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

An integrated proteomics and bioinformatics analyses of hepatitis B virus X interacting proteins and identification of a novel interactor apoA-I

(2013) Tao Zhang et al.   Journal of Proteomics

Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription

(2013) S. Benhenda et al.   JOURNAL OF VIROLOGY

Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation

(2012) Hye Young Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation

(2012) Ekta Khattar et al.   FEBS Journal

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatitis B Virus Encoded X Protein Suppresses Apoptosis by Inhibition of the Caspase-Independent Pathway

(2012) Haiying Liu et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of PP1 Phosphatase Activity by HBx: A Mechanism for the Activation of Hepatitis B Virus Transcription

(2012) D. Cougot et al.   Science Signaling

Proinflammatory cytokine TNF-α increases the stability of hepatitis B virus X protein through NF-κB signaling

(2011) Ruchi Shukla et al.   CARCINOGENESIS

E3 ubiquitin ligase Siah-1 facilitates poly-ubiquitylation and proteasomal degradation of the hepatitis B viral X protein

(2011) Jing Zhao et al.   FEBS LETTERS

Virological breakthrough and resistance in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice

(2011) Chanunta Hongthanakorn et al.   HEPATOLOGY

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

(2011) Julie Lucifora et al.   JOURNAL OF HEPATOLOGY

Comprehensive proteomic analysis of host cell lipid rafts modified by HBV infection

(2011) Na Xie et al.   Journal of Proteomics

The X-Linked Tumor Suppressor TSPX Interacts and Promotes Degradation of the Hepatitis B Viral Protein HBx via the Proteasome Pathway

(2011) Tatsuo Kido et al.   PLoS One

Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylation-associated Recruitment of Transcription Factors to the Promoter

(2011) Xin Yue et al.   Virology Journal

Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review

(2010) George V. Papatheodoridis et al.   JOURNAL OF HEPATOLOGY

The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

(2010) C. Wei et al.   JOURNAL OF IMMUNOLOGY

Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon

(2010) M. Kumar et al.   JOURNAL OF VIROLOGY

High-level expression and large-scale preparation of soluble HBx antigen fromEscherichia coli

(2009) Dong Liu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Risk of hepatocellular carcinoma in hepatitis B and prevention through treatment

(2009) M. SHERMAN   CLEVELAND CLINIC JOURNAL OF MEDICINE

Deregulated Direct Targets of the Hepatitis B Virus (HBV) Protein, HBx, Identified through Chromatin Immunoprecipitation and Expression Microarray Profiling

(2009) Wing-Kin Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Array MAPPIT: High-Throughput Interactome Analysis in Mammalian Cells

(2009) Sam Lievens et al.   JOURNAL OF PROTEOME RESEARCH

Hepatitis B-related hepatocellular carcinoma: epidemiological characteristics and disease burden

(2009) V. T. T. Nguyen et al.   JOURNAL OF VIRAL HEPATITIS

p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2

(2009) Lingling Xian et al.   MOLECULAR BIOLOGY REPORTS

A promiscuous α-helical motif anchors viral hijackers and substrate receptors to the CUL4–DDB1 ubiquitin ligase machinery

(2009) Ti Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRα

(2008) KyeongJin Kim et al.   BIOCHEMICAL JOURNAL

MAPPIT: a versatile tool to study cytokine receptor signalling: Figure 1

(2008) Irma Lemmens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Diagnosis and Treatment of Hepatocellular Carcinoma

(2008) Hashem B. El-Serag et al.   GASTROENTEROLOGY

The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells

(2008) Samuel Martín-Vílchez et al.   HEPATOLOGY

Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A

(2008) Da-Li Zheng et al.   JOURNAL OF HEPATOLOGY

Complex Formation between Heat Shock Protein 72 and Hepatitis B Virus X Protein in Hepatocellular Carcinoma Tissues

(2008) Xiaoping Wang et al.   JOURNAL OF PROTEOME RESEARCH

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities

(2008) Y Li et al.   ONCOGENE

HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint

(2008) S Kim et al.   ONCOGENE

Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model

(2008) Aiping Tong et al.   PROTEOMICS

Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors

(2007) Giovanna Fattovich et al.   JOURNAL OF HEPATOLOGY

Id-1 Induces Proteasome-dependent Degradation of the HBX Protein

(2007) Ming-Tat Ling et al.   JOURNAL OF MOLECULAR BIOLOGY