Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Intrinsic disorder in proteins associated with neurodegenerative diseases

(2010) Vladimir et al.   Frontiers in Bioscience-Landmark

TAR DNA-binding protein 43 in neurodegenerative disease

(2010) Alice S. Chen-Plotkin et al.   Nature Reviews Neurology

Protein disorder in the human diseasome: unfoldomics of human genetic diseases

(2009) Uros Midic et al.   BMC GENOMICS

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

(2009) Vladimir N Uversky et al.   BMC GENOMICS

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Predicting intrinsic disorder in proteins: an overview

(2009) Bo He et al.   CELL RESEARCH

Biophysics of Parkinsons Disease: Structure and Aggregation of α- Synuclein

(2009) Vladimir Uversky et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

CDF it all: Consensus prediction of intrinsically disordered proteins based on various cumulative distribution functions

(2009) Bin Xue et al.   FEBS LETTERS

Metal-free Superoxide Dismutase-1 and Three Different Amyotrophic Lateral Sclerosis Variants Share a Similar Partially Unfolded β-Barrel at Physiological Temperature

(2009) Armando Durazo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mysterious Unfoldome: Structureless, Underappreciated, Yet Vital Part of Any Given Proteome

(2009) Vladimir N. Uversky   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model

(2009) Gabriela Mustata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of structured and intrinsically disordered regions of transmembrane proteins

(2009) Bin Xue et al.   Molecular BioSystems

Improved Disorder Prediction by Combination of Orthogonal Approaches

(2009) Avner Schlessinger et al.   PLoS One

Intrinsically Disordered Proteins and Their Environment: Effects of Strong Denaturants, Temperature, pH, Counter Ions, Membranes, Binding Partners, Osmolytes, and Macromolecular Crowding

(2009) Vladimir N. Uversky   PROTEIN JOURNAL

Assessment of disorder predictions in CASP8

(2009) Orly Noivirt-Brik et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Influence of Sequence Changes and Environment on Intrinsically Disordered Proteins

(2009) Amrita Mohan et al.   PLoS Computational Biology

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Structural Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: A Collapsed Disordered Conformation Underlies Structural Plasticity and Protein-Induced Folding†

(2008) Derek N. Lavery et al.   BIOCHEMISTRY

Prediction of disordered regions in proteins based on the meta approach

(2008) T. Ishida et al.   BIOINFORMATICS

Small-molecule perturbation of competing interactions between c-Myc and Max

(2008) Ariele Viacava Follis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The unfoldomics decade: an update on intrinsically disordered proteins

(2008) A Keith Dunker et al.   BMC GENOMICS

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

(2008) Ariele Viacava Follis et al.   CHEMISTRY & BIOLOGY

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

α-Synuclein Misfolding and Neurodegenerative Diseases

(2008) Vladimir Uversky   CURRENT PROTEIN & PEPTIDE SCIENCE

A careful disorderliness in the proteome: Sites for interaction and targets for future therapies

(2008) Robert B. Russell et al.   FEBS LETTERS

Polyglutamine Expansion Reduces the Association of TATA-binding Protein with DNA and Induces DNA Binding-independent Neurotoxicity

(2008) Meyer J. Friedman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants of the cellular localization and shuttling of TDP-43

(2008) Y. M. Ayala et al.   JOURNAL OF CELL SCIENCE

Signal transduction via unstructured protein conduits

(2008) A Keith Dunker et al.   Nature Chemical Biology

Intrinsic disorder in scaffold proteins: Getting more from less

(2008) Marc S. Cortese et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities

(2008) Dmitri Tolkatchev et al.   PROTEIN SCIENCE

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

(2007) Emanuele Buratti   Frontiers in Bioscience-Landmark

Solvent-induced collapse of α-synuclein and acid-denatured cytochrome c

(2002) Artemiza S. Morar et al.   PROTEIN SCIENCE