Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Review
Pharmacology & Pharmacy
Haseeb Ahsan, Salman Ul Islam, Muhammad Bilal Ahmed, Young Sup Lee
Summary: Cancer is a complex disease that can be prevented or suppressed through chemoprevention. Targeting molecules such as Nrf2, STAT3, and Src, which are involved in various pathways of cancer, can reduce oxidative stress and inflammation and stop cancer initiation and progression.
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lin Gao, Shanze Chen, Malin Hong, Wenbin Zhou, Bilan Wang, Junying Qiu, Jinquan Xia, Pan Zhao, Li Fu, Jigang Wang, Yong Dai, Ni Xie, Qinhe Yang, Hsien-Da Huang, Xiang Gao, Chang Zou
Summary: The study identified KTN1 as a carcinogenic promoter in triple-negative breast cancer (TNBC), with high KTN1 expression associated with poor prognosis. Functional experiments revealed that KTN1 promotes TNBC tumorigenesis and progression through upregulation of the CXCL8 gene. These findings suggest that targeting KTN1 may be a potential therapeutic strategy for TNBC.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Yue Xia, Minghuan Ge, Ling Xia, Guang Shan, Huijun Qian
Summary: This study reveals that the aberrant expression of cathepsin V (CTSV) is associated with a poor outcome in bladder cancer patients. CTSV enhances the inflammatory reaction, thereby promoting the development of bladder cancer. Overexpression of CTSV increases the proliferation and viability of bladder cancer cells, while deletion of CTSV significantly inhibits their proliferation and viability. Furthermore, overexpression of CTSV activates the inflammatory signaling pathway, which can be restored by introducing an NF-kappa B inhibitor.
Review
Biochemistry & Molecular Biology
Supattra Chaithongyot, Phatcharida Jantaree, Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, with environmental factors and dysregulation of the transcription factor nuclear factor kappa B (NF-kappa B) playing crucial roles in its development. NF-kappa B actively participates in tumor microenvironment cell crosstalk, with diverse effects on tumor cell and immune cell populations.
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Maryam Roozbehani, Mohammad Hossein Abdolmohammadi, Maryam Hamzeloo-Moghadam, Shiva Irani, Faranak Fallahian
Summary: Gaillardin exerts its anti-cancer properties in gastric cancer cells by inducing apoptosis through inhibition of NF-kappa B pathway and upregulation of ROS production. This study suggests Gaillardin could be a potential natural agent for future anticancer drug development.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Microbiology
Hironori Nishitsuji, Satoko Iwahori, Mariko Ohmori, Kunitada Shimotohno, Takayuki Murata
Summary: This study reveals the molecular mechanisms behind the induction of proinflammatory cytokines by the SARS-CoV-2 virus. The NSP6 and ORF7a proteins activate the NF-kappa B pathway through interactions with TAK1. The polyubiquitination of NSP6 and ORF7a is essential for NF-kappa B activation, with TRIM13 and RNF121 playing key roles in this process. These findings provide novel insights into the pathogenesis of SARS-CoV-2 and the host immune response.
Article
Multidisciplinary Sciences
Yasuto Takeuchi, Natsuko Kimura, Takahiko Murayama, Yukino Machida, Daisuke Iejima, Tatsunori Nishimura, Minoru Terashima, Yuming Wang, Mengjiao Li, Reiko Sakamoto, Mizuki Yamamoto, Naoki Itano, Yusuke Inoue, Masataka Ito, Nobuaki Yoshida, Jun-ichiro Inoue, Koichi Akashi, Hideyuki Saya, Koji Fujita, Masahiko Kuroda, Issay Kitabayashi, Dominic Voon, Takeshi Suzuki, Arinobu Tojo, Noriko Gotoh
Summary: Adaptor protein FRS20 induces proinflammatory changes in premalignant mammary tissues and is responsible for disease onset, while the FRS2 beta-NF-kappa B axis reveals the molecular link between inflammation changes and tumorigenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jun Xiao, Fei Sun, Ya-Nan Wang, Bo Liu, Peng Zhou, Fa-Xi Wang, Hai-Feng Zhou, Yue Ge, Tian-Tian Yue, Jia-Hui Luo, Chun-Liang Yang, Shan-Jie Rong, Ze-Zhong Xiong, Sheng Ma, Qi Zhang, Yang Xun, Chun-Guang Yang, Yang Luan, Shao-Gang Wang, Cong-Yi Wang, Zhi-Hua Wang
Summary: The role of tumor-associated macrophages (TAMs) and the regulatory mechanisms of macrophage activation in prostate cancer (PCa) are poorly understood. In this study, it was found that PCa growth in mice with macrophage-specific Ubc9 deficiency was suppressed due to enhanced CD8+ T cell response. The study also identified STAT4 as a crucial UBC9-mediated SUMOylation target, with K350 as the major modification site. Furthermore, inhibition of UBC9 with the inhibitor 2-D08 increased the antitumor effect of TAMs and expression of PD-1 on CD8+ T cells, providing valuable insights for cancer therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Immunology
Cise Kizilirmak, Marco E. Bianchi, Samuel Zambrano
Summary: The transcription factor family NF-kappa B plays a crucial role in inflammation and immunity. Live cell imaging has revealed the dynamic nature of NF-kappa B activation, including oscillations in its nuclear localization. This interdisciplinary research has provided insights into the heterogeneous response of NF-kappa B in different cell types and its impact on gene expression. Future steps in this field should focus on filling existing knowledge gaps.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Enping Liu, Jiawei Sun, Jing Yang, Lin Li, Qili Yang, Jiuqin Zeng, Jiayu Zhang, Dahua Chen, Qinmiao Sun
Summary: ZDHHC11 positively regulates NF-kappa B signaling by promoting TRAF6 oligomerization and ligase activity, subsequently activating TAK1 and IKK complexes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)