The translocator protein as a drug target in Alzheimer’s disease

Characterization and Modeling of the Oligomeric State and Ligand Binding Behavior of Purified Translocator Protein 18 kDa from Rhodobacter sphaeroides

(2013) Fei Li et al.   BIOCHEMISTRY

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

Translocator Protein/Peripheral Benzodiazepine Receptor Is Not Required for Steroid Hormone Biosynthesis

(2013) Kanako Morohaku et al.   ENDOCRINOLOGY

In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer’s disease patients

(2013) Andrea Varrone et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease

(2013) A. M. Barron et al.   JOURNAL OF NEUROSCIENCE

Etifoxine analgesia in experimental monoarthritis: A combined action that protects spinal inhibition and limits central inflammatory processes

(2013) Maya Aouad et al.   PAIN

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Mouse TSPO in a lipid environment interacting with a functionalized monolayer

(2012) David Teboul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular imaging of microglia/macrophages in the brain

(2012) Sriram Venneti et al.   GLIA

A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation

(2012) William C Kreisl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety?

(2012) David R Owen et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

(2012) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

(2011) Katherine R. Leaver et al.   ACS Chemical Neuroscience

Shedding light on the mitochondrial permeability transition

(2011) Fernanda Ricchelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Evaluation of [123I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation

(2011) Filomena Mattner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28

(2011) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-  and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders

(2011) J. Maeda et al.   JOURNAL OF NEUROSCIENCE

Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine

(2011) Balázs Gulyás et al.   NEUROIMAGE

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state

(2010) Judy Choi et al.   GLIA

Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation

(2010) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

(2010) Anne Eckert et al.   MOLECULAR NEUROBIOLOGY

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Three-Dimensional Structure of TspO by Electron Cryomicroscopy of Helical Crystals

(2010) Vladimir M. Korkhov et al.   STRUCTURE

Carbon 11–Labeled Pittsburgh Compound B and Carbon 11–Labeled (R)-PK11195 Positron Emission Tomographic Imaging in Alzheimer Disease

(2009) Clayton A. Wiley et al.   ARCHIVES OF NEUROLOGY

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Translocator protein (18 kDa) TSPO: An emerging therapeutic target in neurotrauma

(2009) Vassilios Papadopoulos et al.   EXPERIMENTAL NEUROLOGY

The Translocator Protein (18 kDa): Central Nervous System Disease and Drug Design

(2009) Alana M. Scarf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

Neuroprotective effects of a ligand of translocator protein-18kDa (Ro5-4864) in experimental diabetic neuropathy

(2009) S. Giatti et al.   NEUROSCIENCE

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

(2009) Rainer Rupprecht et al.   SCIENCE

Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding

(2008) Samuel Murail et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Neuroprotective effect of Ro5-4864 following brain injury

(2008) Jean F. Soustiel et al.   EXPERIMENTAL NEUROLOGY

Imaging Microglial Activation During Neuroinflammation and Alzheimer’s Disease

(2008) Sriram Venneti et al.   Journal of Neuroimmune Pharmacology

The Positron Emission Tomography Ligand DAA1106 Binds With High Affinity to Activated Microglia in Human Neurological Disorders

(2008) Sriram Venneti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies

(2008) B. Ji et al.   JOURNAL OF NEUROSCIENCE

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET

(2008) Sriram Venneti et al.   NEUROBIOLOGY OF AGING

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system

(2008) Balázs Gulyás et al.   NEUROCHEMISTRY INTERNATIONAL