Article
Clinical Neurology
Jonathan J. Simone, Matthew R. Green, Cheryl M. McCormick
Summary: As more countries and states legalize the medical use of cannabis, there is a growing interest among health and research professionals in the endocannabinoid system (ECS). This review discusses the maturation of the ECS during adolescence and the consequences of manipulating the ECS during this period, highlighting sex differences and future research directions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Shuangtao Li, Yuanbing Huang, Lijun Yu, Xiaoyu Ji, Jie Wu
Summary: Cannabinoids, isolated from cannabis and present in animal nervous and immune systems, have shown promising clinical medicinal value, particularly in the field of neurodegenerative diseases such as Alzheimer's disease. This review explores the therapeutic potential of cannabinoids in treating Alzheimer's disease, highlighting their interactions with different endocannabinoid receptor subtypes and the role of the endocannabinoid system in this disease. The underlying mechanisms and potential usefulness of cannabinoids in clinical treatment are also discussed.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gabriella Dornyei, Zsolt Vass, Csilla Berta Juhasz, Gyorgy L. Nadasy, Laszlo Hunyady, Maria Szekeres
Summary: Metabolic syndrome is a complex disease state that arises from an unhealthy, sedentary lifestyle. It brings about various metabolic complications and reduces life expectancy. The endocannabinoid system plays a crucial role in signalization processes in both the central nervous system and peripheral tissues, affecting several physiological functions. Understanding cannabinoid receptor functions can offer potential therapeutic effects for the treatment of metabolic diseases like diabetes, insulin resistance, obesity, and hypertension.
Article
Biochemistry & Molecular Biology
Tibor Stark, Fabio Arturo Iannotti, Serena Di Martino, Martina Di Bartolomeo, Jana Ruda-Kucerova, Fabiana Piscitelli, Carsten T. Wotjak, Claudio D'Addario, Filippo Drago, Vincenzo Di Marzo, Vincenzo Micale
Summary: According to a study on Sprague-Dawley rats, prenatal exposure to MAM resulted in behavioral alterations in adulthood, including social withdrawal and cognitive impairment, which mimicked schizophrenia-like symptoms. Neonatal reflex delay and increased levels of 2-AG in the brain were observed prior to these abnormalities. Early treatment with the CB1 antagonist/inverse agonist AM251 reversed schizophrenia-like deficits, whereas it affected the behavioral performance of control rats and increased 2-AG content in the prefrontal cortex.
Review
Behavioral Sciences
Martin Migliaro, Alejandra E. Ruiz-Contreras, Andrea Herrera-Solis, Monica Mendez-Diaz, Oscar E. Prospero-Garcia
Summary: This narrative review article summarizes the current state of knowledge regarding the relationship between the endocannabinoid system (ECS) and aggression across multiple vertebrate species. Experimental evidence indicates that acute administration of phytocannabinoids, synthetic cannabinoids, and the pharmacological enhancement of endocannabinoid signaling decreases aggressive behavior in several animal models. However, research on the chronic effects of cannabinoids on animal aggression has yielded inconsistent findings, indicating a need for further investigation. Cannabinoid receptors, particularly cannabinoid receptor type 1, appear to be an important part of the endogenous mechanism involved in the dampening of aggressive behavior.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Daniela Matei, Dan Trofin, Daniel Andrei Iordan, Ilie Onu, Iustina Condurache, Catalin Ionite, Ioana Buculei
Summary: The endocannabinoid system (ECS) plays a role in various physiological processes and can be activated by physical exercise. Endocannabinoids generated during exercise contribute to the phenomenon of a runner's high, which is associated with pain relief, sedation, heightened euphoria, and reduced anxiety levels. This review provides an overview of the current understanding of the relationship between endocannabinoids and physical effort, summarizing relevant studies in the literature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Nicholas DiPatrizio
Summary: The gut-brain signaling system, particularly the endocannabinoid system in the upper gastrointestinal tract, plays a crucial role in controlling food intake and the dysregulation of this system is associated with obesity. Direct and indirect interactions between endocannabinoids and vagal afferent neurons are key mechanisms in this control, with a focus on how diet-induced obesity impacts these pathways.
Review
Biochemistry & Molecular Biology
Tristyn L. Clarke, Rachael L. Johnson, Jonathan J. Simone, Robert L. Carlone
Summary: This review provides a comprehensive summary of the endocannabinoid system, with a focus on the current advances in the contributions of the endocannabinoid system to invertebrate neurodevelopment and regeneration. It emphasizes the promising results of research investigating the role of cannabinoids in regeneration and neurodevelopment in vertebrate models, while highlighting the importance of invertebrate species as models for regeneration research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Toobah Farooqi, Deep Jyoti Bhuyan, Mitchell Low, Justin Sinclair, Mathew Leonardi, Mike Armour, Valentino Remorgida
Summary: This narrative review explores the role of the endocannabinoid system (ECS) and the gut microbiota in endometriosis. The review finds that both the ECS and microbiota influence endometriosis, with the former regulating inflammation and pain perception and the latter influencing immune responses and hormonal balance. Dysregulation of the ECS and the gut microbiota can impact endometriosis symptoms and progression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Urszula Skupio, Julia Welte, Roman Serrat, Abel Eraso-Pichot, Francisca Julio-Kalajzi, Doriane Gisquet, Astrid Cannich, Sebastien Delcasso, Isabelle Matias, Unai B. Fundazuri, Sandrine Pouvreau, Antonio C. Pagano Zottola, Gianluca Lavanco, Filippo Drago, Inigo Ruiz de Azua, Beat Lutz, Luigi Bellocchio, Arnau Busquets-Garcia, Francis Chaouloff, Giovanni Marsicano
Summary: Corticosteroid-mediated stress responses involve complex brain circuits and mitochondrial activity, and the endocannabinoid system plays a role in regulating these processes. The study shows that corticosterone impairs novel object recognition (NOR) task performance in mice through the activation of mitochondrial CB1 receptors and the regulation of neuronal mitochondrial calcium levels. Different brain circuits are modulated by this mechanism to mediate the effects of corticosterone during specific phases of the task.
Review
Clinical Neurology
Ranjini Garani, Jeremy J. Watts, Romina Mizrahi
Summary: Despite evidence of endocannabinoid system involvement in psychiatric disorders, our understanding remains limited. Studies show alterations of brain CB1 receptors and peripheral blood endocannabinoids in psychotic and mood disorders, sensitive to treatment status, disease state, and symptom severity. More investigation beyond the CB1 receptor is needed to fully understand the role of the endocannabinoid system in these disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Riikka M. Ajalin, Haidar Al-Abdulrasul, Jouni M. Tuisku, Jussi E. S. Hirvonen, Tero Vahlberg, Salla Lahdenpohja, Juha O. Rinne, Anna E. Bruck
Summary: CB1 receptor availability is lower in patients with Parkinson's disease compared to healthy controls. Dopaminergic medication increases CB1 receptor availability towards normal levels.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Arianna De Rosa, Anna Di Maio, Silvia Torretta, Martina Garofalo, Valentina Giorgelli, Rita Masellis, Tommaso Nuzzo, Francesco Errico, Alessandro Bertolino, Srinivasa Subramaniam, Antonio Rampino, Alessandro Usiello
Summary: This study investigates the role of RasGRP1 in schizophrenia (SCZ) and its potential as a biomarker and therapeutic target. The results suggest that RasGRP1 may mediate the risk for SCZ by involving the dorsolateral-prefrontal cortex (DLPFC) and peripheral blood. Further studies are encouraged to explore its mechanisms and clinical applications.
Review
Biochemistry & Molecular Biology
Ishtiaq Ahmed, Saif Ur Rehman, Shiva Shahmohamadnejad, Muhammad Anjum Zia, Muhammad Ahmad, Muhammad Muzammal Saeed, Zain Akram, Hafiz M. N. Iqbal, Qingyou Liu
Summary: The endocannabinoid system in the human body plays a crucial role in physiological functions, immune system modulation, and therapeutic potential. Research indicates that cannabinoids have promising anti-tumor properties and potential benefits in various disease treatments.
Review
Pharmacology & Pharmacy
Ines Gallego-Landin, Alba Garcia-Baos, Adriana Castro-Zavala, Olga Valverde
Summary: Major depressive disorder is a prevalent and debilitating disease with limited treatment options. Recent research suggests the endocannabinoid system plays a crucial role in depression, impacting neurotransmission and other systems. Before further research, understanding the relationship between the two is essential.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Psychiatry
Jose A. Crippa, Luiz C. Pereira Junior, Livia C. Pereira, Patricia M. Zimmermann, Liberato Brum Junior, Leticia M. Rechia, Isabella Dias, Jaime E. Hallak, Alline C. Campos, Francisco S. Guimaraes, Regina H. Queiroz, Antonio W. Zuardi
Summary: This study compared plasma concentrations of CBD following oral administration of two formulations (powder and oil) and evaluated their effects on responses to emotional stimuli. The results showed that neither formulation altered responses to emotional stimuli in healthy subjects, but the oil-based CBD formulation had a faster onset and higher oral bioavailability.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Renata K. Carvalho, Thiago L. Rocha, Fabio H. Fernandes, Bruno B. Goncalves, Maingredy R. Souza, Amanda A. Araujo, Caio C. Barbosa, Daniela M. Silva, Hericles M. Campos, Mariana Tomazett, Paulo C. Ghedini, Francisco S. Guimaraes, Monica L. Andersen, Fernanda C. A. Santos, Renata Mazaro-Costa
Summary: CBD has negative effects on spermatogenesis and sperm quality, reducing sperm quality and causing DNA damage, affecting sperm motility and acrosome integrity. However, it does not affect reproductive organ weight, sperm count, and hormone levels. These effects may be associated with dysregulation of the endocannabinoid system.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Clinical Neurology
Nicole Rodrigues Silva, Francisco Isaac Fernandes Gomes, Alexandre Hashimoto Pereira Lopes, Isadora Lopes Cortez, Jessica Cristina dos Santos, Conceicao Elidianne Anibal Silva, Raphael Mechoulam, Felipe Villela Gomes, Thiago Mattar Cunha, Francisco Silveira Guimaraes
Summary: The CBD fluorinated analog PECS-101 shows potential as a therapeutic option to alleviate PTX-induced neuropathic pain by potentially activating PPAR gamma in macrophages.
Article
Neurosciences
Livia Maria Bolsoni, Jose Alexandre S. Crippa, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Antonio Waldo Zuardi
Summary: Studies suggest that CBD has anxiolytic properties and may attenuate symptoms induced by recall of traumatic events in individuals with PTSD. This double-blind trial found that CBD in a dosage of 300 mg significantly reduced cognitive impairment associated with trauma recall, with this effect lasting for a week after administration. However, CBD did not significantly affect anxiety, alertness, or discomfort induced by recall, and there were no differences in physiological measures between the CBD and placebo groups.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Jaqueline M. Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S. Guimaraes, Leandro J. Bertoglio
Summary: Growing evidence suggests that cannabidiol (CBD) modulates aversive memories and anxiety-related responses in females. This has therapeutic implications for treating anxiety and stress-related disorders in women. Studies in adult female rats show that CBD can attenuate the behavioral manifestations of learned fear and anxiety.
Article
Psychiatry
Andreza M. Cavichioli, Thamyris Santos-Silva, Anthony A. Grace, Francisco S. Guimaraes, Felipe Gomes
Summary: This study suggests that levetiracetam can attenuate the adverse outcomes associated with schizophrenia caused by stress during adolescence, by reversing the behavioral changes, ventral hippocampus hyperactivity, and enhanced ventral tegmental area dopamine system activity.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Amanda J. Sales, Izaque S. Maciel, Carlos C. Crestani, Francisco S. Guimara, Samia R. L. Joca
Summary: SAMe exerts antidepressant effects by regulating serotonin synthesis and 5-HT1A receptor activation, reducing immobility time in the forced swimming test in mice.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Danielle Diniz Aguiar, Cristina da Costa Oliveira, Flavia Cristina Sousa Fonseca, Douglas Lamounier de Almeida, William Valadares Campos Pereira, Francisco Silveira Guimara, Andrea Castro Perez, Igor Dimitri Gama Duarte, Thiago Roberto Lima Romero
Summary: This study evaluated the analgesic effects of CBD when administered peripherally for the treatment of acute neuropathic pain, and investigated the involvement of the 5-HT1A and TRPV1 receptors. The results showed that CBD induced dose-dependent antinociceptive effects, with the highest potency observed at a dose of 30 mu g/paw. Furthermore, selective antagonists of the 5-HT1A and TRPV1 receptors partially reversed the antinociceptive effects of CBD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Ana Maria Raymundi, Jeferson Machado Batista Sohn, Bruna Wuilleumier Salemme, Nathalie Carla Cardoso, Francisco Silveira Guimaraes, Cristina Aparecida Stern
Summary: Cannabis preparations could be an effective treatment for post-traumatic stress disorder. The study found that THC has a bidirectional effect on fear memory labilization, and this effect is associated with the involvement of hippocampal GluN2B-NMDA receptors.
Article
Neurosciences
Mauricio dos Santos Pereira, Bruna Maitan Santos, Rocio Gimenez, Francisco Silveira Guimaraes, Rita Raisman-Vozari, Elaine Del Bel, Patrick Pierre Michel
Summary: Research found that 4'-F-CBD and HU-910, two synthetic cannabinoids, have anti-inflammatory potential and may have therapeutic utility in treating neuroinflammatory conditions.
Article
Psychiatry
Thamyris Santos-Silva, Dogukan Hazar Ulgen, Caio Fabio Baeta Lopes, Francisco S. Guimaraes, Luciane Carla Alberici, Carmen Sandi, Felipe V. Gomes
Summary: Adolescent individuals show significant diversity in cortical dynamics and behavioral outcomes. The developing adolescent brain is sensitive to social experiences and environmental insults, which can influence the emergence of personality traits. Mitochondria play a crucial role in brain maturation and the development of mental illnesses, with specific mitochondrial features in certain brain regions accounting for behavioral differences in adulthood. This study investigates whether distinct adolescent behavioral phenotypes and the consequences of early adolescent stress exposure are associated with changes in PFC mitochondria-related genes and respiratory chain capacity.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Ligia RenataRodrigues Tavares, Daniela Baptista-de-Souza, Lucas Canto-de-Souza, Cleopatra da Silva Planeta, Francisco Silveira Guimaraes, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza
Summary: Living with a partner experiencing chronic pain can lead to pain hypersensitivity and increased expression of 5-HT3 receptor and glutamic acid decarboxylase 67 in the amygdala. The anxiolytic benzodiazepine midazolam (MDZ) and cannabidiol (CBD) can attenuate this hypersensitive behavior, while the 5-HT3 receptor antagonist ondansetron can prevent their antinociceptive effects. These findings suggest that 5-HT3 receptor and GABAergic mechanisms in the amygdala play a role in pain hypersensitivity induced by empathy for pain, and that MDZ and CBD may be potential therapies for emotional pain disorders.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Pedro Henrique Gobira, Jacob LaMar, Jade Marques, Ariandra Sartim, Kennia Silveira, Luana Santos, Gregers Wegener, Francisco S. Guimaraes, Ken Mackie, Hui-Chen Lu, Samia Joca
Summary: This study investigates the involvement of cannabinoid type 1 receptors (CB1R) in the antidepressant and psychostimulant effects induced by ketamine. The results suggest that CB1R mediate the psychostimulant side effects of ketamine, but do not play a role in its antidepressant properties. Furthermore, pharmacological blockade of CB1R has similar antidepressant effects, but does not potentiate the effects of ketamine.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Meeting Abstract
Neurosciences
Debora Colodete, Anthony Grace, Francisco Guimaraes, Felipe Gomes
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jose Alexandre S. Crippa, Julia Cozar Pacheco, Antonio W. Zuardi, Francisco S. Guimaraes, Alline Cristina Campos, Flavia de Lima Osorio, Sonia Regina Loureiro, Rafael G. dos Santos, Jose Diogo S. Souza, Juliana Mayumi Ushirohira, Rafael Rinaldi Ferreira, Karla Cristinne Mancini Costa, Davi Silveira Scomparin, Franciele Franco Scarante, Isabela Pires-Dos-Santos, Raphael Mechoulam, Flavio Kapczinski, Benedito A. L. Fonseca, Danillo L. A. Esposito, Afonso Dinis Costa Passos, Amaury Lelis Dal Fabbro, Fernando Bellissimo-Rodrigues, Eurico Arruda, Sandro Scarpelini, Maristela Haddad Andraus, Julio Cesar Nather Junior, Danilo Tadao Wada, Marcel Koenigkam-Santos, Antonio Carlos Santos, Geraldo Busatto Filho, Jaime E. C. Hallak
Summary: A clinical trial conducted in Brazil showed that daily administration of 300 mg CBD for 14 days failed to alter the clinical evolution of COVID-19, with no significant effect on symptom resolution. CBD was well tolerated, producing mostly mild and transient side effects.
CANNABIS AND CANNABINOID RESEARCH
(2022)
