Review
Clinical Neurology
L. Roosen, P. Sienaert
Summary: This paper provides an overview of evidence-based treatment options for rapid cycling in bipolar disorder, highlighting medications such as aripiprazole, olanzapine, quetiapine, valproate, and lamotrigine. However, evidence regarding the treatment of rapid cycling remains scarce, indicating the need for future research to further validate the efficacy of these treatment methods.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Behavioral Sciences
Federica Colombo, Federico Calesella, Mario Gennaro Mazza, Elisa Maria Teresa Melloni, Marco J. Morelli, Giulia Maria Scotti, Francesco Benedetti, Irene Bollettini, Benedetta Vai
Summary: Applying machine learning to objective markers can improve the accuracy of bipolar disorder diagnosis and overcome prognosis uncertainty caused by subjectivity. However, future studies should adopt best practices in methodology for further advancements in this field.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Biology
Brett D. M. Jones, Salman Farooqui, Stefan Kloiber, Muhammad Omair Husain, Benoit H. Mulsant, Muhammad Ishrat Husain
Summary: Major depressive disorder (MDD) and bipolar disorder (BD) are often chronic and associated with metabolic dysfunction, leading to increased interest in novel treatments targeting metabolic pathways. However, current evidence on the effects of lipid lowering agents and anti-diabetics drugs on mood symptoms is conflicting, necessitating further studies.
Article
Clinical Neurology
Shiwei Lin, Chao Zhang, Yingli Zhang, Shengli Chen, Xiaoshan Lin, Bo Peng, Ziyun Xu, Gangqiang Hou, Yingwei Qiu
Summary: This study identified the shared and diagnosis-specific neurobiological mechanisms in patients with bipolar disorder (BD) and unipolar disorder (UD), providing a better understanding of the neuropathology of these disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Peter Falkai, Nikolaos Koutsouleris, Katja Bertsch, Mirko Bialas, Elisabeth Binder, Markus Buehner, Alena Buyx, Na Cai, Silvia Cappello, Thomas Ehring, Jochen Gensichen, Johannes Hamann, Alkomiet Hasan, Peter Henningsen, Stefan Leucht, Karl Heinz Moehrmann, Elisabeth Nagelstutz, Frank Padberg, Annette Peters, Lea Pfaeffel, Daniela Reich-Erkelenz, Valentin Riedl, Daniel Rueckert, Andrea Schmitt, Gerd Schulte-Koerne, Elfriede Scheuring, Thomas G. Schulze, Rudolf Starzengruber, Susanne Stier, Fabian J. Theis, Juliane Winkelmann, Wolfgang Wurst, Josef Priller
Summary: The Federal Ministry of Education and Research has issued a call for a nationwide research network on mental disorders, the German Center of Mental Health. This center aims to reduce chronicity and mortality of mental illnesses by deepening understanding, predicting accurately, and providing personalized prevention and therapeutic management.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Marta Ielmini, Ivano Caselli, Flavio Critelli, Michele Mattia, Alessandro Bellini, Camilla Callegari
Summary: This systematic review with meta-analysis evaluates the utility of pharmacogenetic tests (PGTs) in the routine clinical treatment of mood disorders. The results indicate that PGT suggestions can lead to better efficacy outcomes for patients with major depressive disorder (MDD), but not for patients with bipolar disorder (BD). However, PGTs show promising results in terms of setting up more tolerated therapies. Overall, PGTs are important in supporting clinicians' choices in psychopharmacological therapies.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Laura Montejo, Brisa Sole, Esther Jimenez, Roger Borras, Derek Clougher, Maria Reinares, Maria J. Portella, Anabel Martinez-Aran, Eduard Vieta, Caterina del Mar Bonnin, Carla Torrent
Summary: This study describes the cognitive performance in different age groups of individuals with bipolar disorder. The results demonstrate that older age is associated with a selective cognitive decline in the attentional domain in individuals with bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Michela Lupo, Giusy Olivito, Andrea Gragnani, Marco Saettoni, Libera Siciliano, Corinna Pancheri, Matteo Panfili, Marco Bozzali, Roberto Delle Chiaie, Maria Leggio
Summary: This study compared the patterns of cerebellar alterations in patients with bipolar disorder and those with cerebellar neurodegenerative pathologies, revealing similarities and differences in grey matter loss in the anterior and posterior cerebellar regions. The findings suggest a potential role of the cerebellum in cognitive and mood dysregulation symptoms of bipolar disorder, indicating common and different alteration patterns in specific cerebellar lobules between the two groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Ana M. Diaz-Zuluaga, Jorge I. Velez, Mauricio Cuartas, Johanna Valencia, Mauricio Castano, Juan David Palacio, Mauricio Arcos-Burgos, Carlos Lopez-Jaramillo
Summary: This study developed a personalized prediction model for lithium response in bipolar disorder patients using machine learning techniques. The model that included ancestry as a variable showed the best performance, and clinical variables were also important predictors. This prediction framework has potential clinical applications.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yujie Wang, Xinquan Wang, Xiaoyu Gu, Jie Pan, Zhen Ouyang, Wenrui Lin, Wu Zhu, Mi Wang, Juan Su
Summary: This study used bidirectional Mendelian randomization to investigate the causal relationship between psoriasis and common psychiatric disorders. The results suggested a possible causal association between psoriasis and bipolar disorder, as well as psoriasis and major depressive disorder. However, no significant causal associations were found between psoriasis and schizophrenia, as well as psoriasis and anxiety disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Giulia Cattarinussi, Giuseppe Delvecchio, Fabio Sambataro, Paolo Brambilla
Summary: This study provides an overview of the association between polygenic risk score (PRS) for major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) and MRI abnormalities. The study found that PRS for BD and SCZ showed either positive or negative correlations with cortical thickness, mostly involving fronto-temporal areas. PRS for MDD was associated with cortical alterations in prefrontal regions in healthy subjects. Overall, the evidence on the effect of PRS for these psychiatric disorders on the brain is heterogeneous and inconclusive.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Riccardo Bortoletto, Fabiana Piscitelli, Anna Candolo, Sagnik Bhattacharyya, Matteo Balestrieri, Marco Colizzi
Summary: This systematic review examines the biobehavioral role of palmitoylethanolamide (PEA) in psychosis. The findings suggest that PEA may serve as a potential biomarker for psychosis and supplementation of PEA could be beneficial for the treatment of the disorder.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
John de Back Jr, Erin P. Vaughan, Emily C. Kemp, Paul J. Frick, Emily L. Robertson, Toni M. Walker, Paige Picou
Summary: Due to the need for early identification of bipolar spectrum disorders, the newly developed Mood Disorder Assessment Schedule (MDAS) was tested in a sample of 396 inpatient adolescents. The MDAS showed stronger clinical utility than the standard diagnostic interview in identifying individuals at risk for bipolar spectrum disorders. This promising diagnostic tool may facilitate earlier diagnosis and prevent harmful effects of improper treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Monica Macellaro, Nicolaja Girone, Laura Cremaschi, Monica Bosi, Bruno Mario Cesana, Federico Ambrogi, Valentina Caricasole, Federica Giorgetti, Terence A. Ketter, Bernardo Dell'Osso
Summary: This study retrospectively evaluated the applicability and progression of four staging models in a sample of 100 bipolar disorder patients. The results showed a pattern of stage worsening for each model, with a significant increase at each time point. Patients with lower education level, younger age at first episode, shorter illness duration, and shorter duration of untreated illness showed greater stage increases. Lower stage values were associated with certain characteristics, such as BD II, no psychiatric hospitalization, depressive onset, and few lifetime episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Martin T. Strassnig, Michelle L. Miller, Raeanne Moore, Colin A. Depp, Amy E. Pinkham, Philip D. Harvey
Summary: The study found that people with bipolar disorder and schizophrenia exhibited high levels of unproductive and passive activities, which were predicted by momentary sadness. These activity patterns were consistent with descriptions of avolition and minimally differentiated between people with bipolar disorder and schizophrenia.
PSYCHIATRY RESEARCH
(2021)
