Article
Clinical Neurology
Brittany O'Brien, Marijn Lijffijt, Jaehoon Lee, Ye Sil Kim, Allison Wells, Nicholas Murphy, Nithya Ramakrishnan, Alan C. Swann, Sanjay J. Mathew
Summary: The study used GMM to analyze response trajectories of depressed patients receiving ketamine treatment, revealing three distinct response trajectories. Among severely depressed patients, there were significant differences in antidepressant response to ketamine. Patients with childhood maltreatment and severe baseline depression showed consistent response to ketamine-induced blockade of behavioral sensitization.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Huang Lin, Shujuan Xiao, Lei Shi, Xiao Zheng, Yaqing Xue, Qilong Yun, Ping Ouyang, Dong Wang, Hong Zhu, Chichen Zhang
Summary: The study found that multimorbidity is significantly positively associated with depression, anxiety, and stress symptoms in older adults, especially in females. Therefore, promoting access to multimorbidity treatment for older adults of different sexes may effectively promote mental health in China.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Brittany O'Brien, Jaehoon Lee, Seungman Kim, Guriqbal S. Nandra, Prabhneet Pannu, Alan C. Swann, Nicholas Murphy, Amanda J. F. Tamman, Dania Amarneh, Marijn Lijffijt, Lynnette A. Averill, Sanjay J. Mathew
Summary: The goal of this study was to replicate previous findings of three distinct treatment response pathways associated with repeated intravenous (IV) ketamine infusions among patients with major depressive disorder (MDD). The results showed that only about a third of depressed patients benefited significantly from an acute induction course of ketamine infusions.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Laura Raffaelli, Sara Poletti, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: This study investigated the impact of Neutrophil-to-lymphocyte ratio (NLR) on treatment response in Major Depressive Disorder (MDD) patients, and the influence of sex and hippocampal volume on this relationship. The results showed that NLR had a different effect on treatment response in females compared to males. Additionally, NLR negatively affected hippocampal volume in females, and hippocampal volume partially mediated the effect of NLR on treatment response in females.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mitjan Morr, Jeanine Noell, Daphne Sassin, Jule Daniels, Alexandra Philipsen, Benjamin Becker, Birgit Stoffel-Wagner, Rene Hurlemann, Dirk Scheele
Summary: Loneliness may contribute to vulnerability to intrusive memories after trauma in healthy men, with altered limbic processing of fear signals being a potential underlying mechanism. Lonely men showed more intrusions and altered amygdala activity, while loneliness did not have the same impact on women.
Article
Psychiatry
Mark M. Gergues, Christine N. Yohn, Anusha Bharadia, Marjorie R. Levinstein, Benjamin Adam Samuels
Summary: This study developed a method to assess treatment resistance in mice to antidepressants, revealing differences in expression of Activin signaling-related genes in the dentate gyrus (DG) between responders and non-responders to fluoxetine treatment. The findings suggest that targeted manipulations of DG can modify the behavioral response to fluoxetine bidirectionally, offering a new therapeutic avenue for more effective antidepressant treatments.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Immunology
Andreas Menke, Felix Nitschke, Anna Hellmuth, Jacqueline Helmel, Catherina Wurst, Saskia Stonawski, Manuel Blickle, Carolin Weiss, Heike Weber, Leif Hommers, Katharina Domschke, Juergen Deckert
Summary: This study investigates the effects of childhood trauma and severe events later in life on the stress-response systems of the body in depressed patients. Severe recent life events were found to impair the stress-response systems and treatment response in patients with major depressive disorder. Additional treatment options, such as psychotherapy or immune-modulating approaches, may be needed for patients with a history of severe life events.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Neurosciences
Jianfeng Liu
Summary: The stress system in the brain plays a crucial role in protecting humans and animals from harmful stimuli. Excessive stress can lead to maladaptive changes in the stress system and result in depression. Recent evidence suggests that PKM zeta is involved in stress response and depressive-like behavior, and it could be a molecular target for developing novel antidepressants.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Psychology, Biological
Marcia C. Chavez, Maria Ragusa, Kayla Brooks, Chakeer Drake-Frazier, Isabella Ramos, Megan Zajkowski, Kalynn M. Schulz
Summary: The study found that prenatal and adolescent stress have different effects on fear memory, with no cumulative effects observed in males and females.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Clinical Neurology
Caitlin A. Madison, Roanna A. Debler, Nathan I. Vardeleon, Lauren Hillbrick, Arul Jayaraman, Stephen Safe, Robert S. Chapkin, Shoshana Eitan
Summary: Our study found that 1,4-dihydroxy-2-napthoic acid (DHNA) has the potential to act as an antidepressant in female mice, but not in males. However, DHNA can mitigate stress effects and reactivity in male mice.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Kehinde E. Cole, Ryan G. Parsons
Summary: There is evidence that prior experience can alter memory formation, but little is known about whether this effect is similar in both sexes. This study found that male rats trained with auditory fear conditioning showed facilitated learning to subsequent visual fear conditioning, while females only showed facilitation with a one-hour interval.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Behavioral Sciences
Erin P. Harris, Andrew J. McGovern, Thieza G. Melo, Aaron Barron, Yvonne M. Nolan, Olivia F. O'Leary
Summary: Stress during childhood is a significant risk factor for depression, with higher prevalence in women suggesting biological sex plays a role. This study aimed to investigate whether stress during the prepubertal period induces sex-specific changes in anxiety-like behavior, anhedonia, and antidepressant-like behavior in adulthood. The results showed that juvenile stress led to long-lasting effects on antidepressant-like and reward-seeking behavior, potentially due to alterations in catecholaminergic innervation of the medial prefrontal cortex.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ikumi Mizuno, Shingo Matsuda, Suguru Tohyama, Akihiro Mizutani
Summary: The prevalence of PTSD is higher in women than in men, and females exhibit higher resistance to fear extinction than males. The involvement of the cannabinoid system in fear memory and extinction is unclear, particularly regarding sex differences.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yoshiki Matsuda, Nobuyuki Ozawa, Takiko Shinozaki, Kazuhisa Aoki, Naomi Nihonmatsu-Kikuchi, Toshikazu Shinba, Yoshitaka Tatebayashi
Summary: Chronic antidepressant treatment can significantly alleviate social avoidance, sleep disturbances, and EEG abnormalities in rodent chronic stress models. Additionally, reduced REM sleep theta power may be a core sleep symptom in socially defeated rats.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Yuka Ishikawa, Shiho Kitaoka, Yuko Kawano, Shinichi Ishii, Tomohide Suzuki, Kanako Wakahashi, Taro Kato, Yoshio Katayama, Tomoyuki Furuyashiki
Summary: Chronic stress induces changes in neutrophils in two strains of mice, affecting bone marrow, spleen, and blood. BALB/c mice show a stronger stress response. These findings may contribute to our understanding of the pathophysiology of mental illness.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)