Review
Biochemistry & Molecular Biology
Jacek Kabzinski, Monika Maczynska, Ireneusz Majsterek
Summary: This article discusses the potential use of microRNAs in the diagnosis of head and neck squamous cell carcinoma, highlighting their application in radiotherapy and immunotherapy, as well as addressing the challenges and future research directions in developing this promising technology.
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elham Badrlou, Atefe Abak, Mohammad Taheri
Summary: miRNAs play a significant role in CRC by influencing the expression and activity of CRC-related pathways and interacting with long non-coding RNAs. Levels of miRNAs can be used to distinguish CRC patients from healthy controls. Despite evaluation of therapeutic application of miRNAs in CRC in animal models, it has not been verified in clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Soudeh Ghafouri-Fard, Ali Khanbabapour Sasi, Atefe Abak, Hamed Shoorei, Ali Khoshkar, Mohammad Taheri
Summary: miRNAs play a significant role in breast carcinogenesis by modulating key processes and potentially affecting treatment outcomes. Their presence in the peripheral blood of patients also offers a new avenue for non-invasive diagnosis of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sanghyun Roh, Sooyoun Kim, Inpyo Hong, Minho Lee, Han Jo Kim, Tae Sung Ahn, Dong Hyun Kang, Moo-Jun Baek, Hyoung Jong Kwak, Chang-Jin Kim, Dongjun Jeong
Summary: In this study, the TSPAN5 gene was identified as an important biomarker for predicting the prognosis of patients with colorectal cancer (CRC). Suppression of TSPAN5 was found to decrease cancer cell proliferation, migration, invasion, and tumorigenicity, suggesting its potential as a therapeutic target. Evaluating TSPAN5 expression may help in prognosis observation and treatment determination for CRC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Neda Yaghoubi, Farnaz Zahedi Avval, Majid Khazaei, Seyed Hamid Aghaee-Bakhtiari
Summary: miRNAs, as highly sensitive and specific markers, play important roles in the diagnosis, prognosis, and treatment of colorectal cancer. They can serve as quantifiable and effective molecular tools, offering potential new strategies for early cancer detection and treatment.
CELLULAR SIGNALLING
(2021)
Article
Pharmacology & Pharmacy
Nadine De Godoy Torso, Julia Coelho Franca Quintanilha, Maria Aparecida Cursino, Eder De Carvalho Pincinato, Pia Loren, Luis A. Salazar, Carmen Silvia Passos Lima, Patricia Moriel
Summary: The use of miRNAs as renal biomarkers shows promise for evaluating cisplatin-induced nephrotoxicity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Gazi Nurun Nahar Sultana, Ferdowsi Akter, S. M. Hasan Israfil, Utpal Chandra Ray, Rumana Akther Jahan, Mohammad Shawkat Ali, Salim Al Din, Shafiqur Rahman, Rezaul Halim, Mohammad Sahajadul Alam
Summary: According to the GLOBOCAN 2020 report, breast cancer is the most common cancer among women in the United States. This study investigates the use of circulating cell-free DNA (cfDNA) as a diagnostic and prognostic marker for breast cancer. The combination of UV spectrophotometric, fluorometric, and real-time qPCR assays shows promising results in measuring cfDNA levels.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiao-long Mi, Yu-ping Gao, Da-jie Hao, Zhi-jun Zhang, Zheng Xu, Tong Li, Xue-wen Li
Summary: This study aimed to determine the diagnostic accuracy of circulating miR-21-5p and miR-126 as biomarkers for patients with AMI and IR-ATO. The results showed that miR-21-5p and miR-126 exhibited considerable diagnostic accuracy for IR-ATO AMI, suggesting their potential as promising prognostic biomarkers for AMI and IR-ATO patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Oncology
Hussein Al-Akhrass, Niki Christou
Summary: MiRNAs are increasingly important in the diagnosis, prognosis, and treatment decisions for colorectal cancers, with the need to identify the most sensitive and specific miRNAs through multicentric prospective studies for different goals. MiRNAs are becoming a key part of the healthcare management armamentarium for colorectal cancers due to their diversity and feasibility of use.
Article
Oncology
Houshi Xu, Anke Zhang, Xiaying Han, Yanning Li, Zeyu Zhang, Liying Song, Wei Wang, Meiqing Lou
Summary: ITGB2 expression is significantly elevated in high-grade gliomas and predicts poor prognosis; high and low ITGB2 expression subgroups show different clinical outcomes and immune activation status; glioma patients with high ITGB2 expression levels have better response to immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Junlan Feng, Qing Wei, Muqing Yang, Xiaodong Wang, Bin Liu, Jiyu Li
Summary: The study demonstrates that a miRNA-based classifier can serve as a reliable predictive tool for determining prognosis in patients with stage II/III CRC, identifying high-risk patients for personalized clinical management and surveillance.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Francesca Precazzini, Simone Detassis, Andrea Selenito Imperatori, Michela Alessandra Denti, Paola Campomenosi
Summary: Research on microRNAs as potential biomarkers for cancer, immune-related diseases, or cardiac pathogenic diseases has increased significantly in recent years. However, inconsistencies in the literature and technological limitations have prevented microRNAs from being used clinically.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Siyuan Weng, Zaoqu Liu, Xiaofeng Ren, Hui Xu, Xiaoyong Ge, Yuqing Ren, Yuyuan Zhang, Qin Dang, Long Liu, Chunguang Guo, Richard Beatson, Jinhai Deng, Xinwei Han
Summary: The study identified that the SCG2 gene is closely associated with the chemotherapy response in colorectal cancer patients, with high expression predicting poorer prognosis and showing significantly higher expression in the APC non-mutation group. The SCG2 high expression subgroup is more suitable for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Mengfeng Liu, Xiran Yu, Jianlong Bu, Qifan Xiao, Sitong Ma, Naozhong Chen, Changfa Qu
Summary: This study found that miRNAs in salivary exosomes may serve as biomarkers for the prediction and diagnosis of lung cancer. By miRNA sequencing and qPCR validation, differentially expressed miRNAs between lung cancer and non-lung cancer groups were identified, which were associated with pathways related to cancer.
FRONTIERS IN GENETICS
(2023)
