Journal
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
Volume 11, Issue 7, Pages 711-720Publisher
EXPERT REVIEWS
DOI: 10.1586/ERM.11.59
Keywords
clinical assays; diagnostics; heterogeneous immunoassays; magnetic particles; microfluidics; particles; surface-based
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Funding
- Engineering and Physical Sciences Research Council in the UK
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The need for fast, specific and portable diagnostic systems for clinical assays has, in recent years, led to an explosion of research into microfluidic chip-based immunoassays towards rapid point-of-care analysis. Such devices exploit small dimensions, superior fluidic control and low reagent volumes to allow a number of clinically important procedures to be achieved with improvements on conventional methods, many of which rely on the surface-based binding of antigens to antibodies. Here, we discuss recent developments and innovations in the area of on-chip surface-based immunoassays and provide an outlook on the potential of such platforms for future diagnostics.
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