Journal
EXPERT REVIEW OF MEDICAL DEVICES
Volume 11, Issue 2, Pages 121-135Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/17434440.2014.882046
Keywords
endothelial progenitor cells; percutaneous coronary intervention; restenosis; sirolimus; stent; stent thrombosis
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Funding
- OrbusNeich
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In contrast to the use of cytotoxic or cytostatic drugs, a pro-healing' approach may have an effect that is beneficial on clinical outcomes. The endothelial progenitor cell capturing stent (ECS) technology accelerates re-endothelialization after implantation in animal models and in the human arteriovenous shunt model. Several clinical studies have shown its safety in non-complex lesions. However, in the prevention of in-stent restenosis in complex lesions, the ECS is less effective compared with drug-eluting stents. The novel COMBO dual therapy stent is the first stent to combine accelerated endothelial coverage and control of neo-intimal proliferation using a pro-healing technology with an abluminal elution of sirolimus. In the randomized REMEDEE trial, the COMBO dual therapy stent showed similar angiographic and clinical outcomes compared to the paclitaxel-eluting stent. The REMEDEE-OCT study showed equal vascular healing as assessed by optical coherence tomography of the COMBO dual therapy stent compared to the Xience-V stent.
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