Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.
Review
Pharmacology & Pharmacy
Ta-Hsin Tsung, Yi-Hao Chen, Da-Wen Lu
Summary: The complex nature of the ocular drug delivery barrier poses challenges to effective drug administration. One promising approach is the use of biodegradable formulations, such as hydrogels, implants, and polymeric nanocarriers. Research in these areas is rapidly growing. This review provides an overview of recent updates in biodegradable formulations for ocular drug delivery, exploring their clinical use in different ocular diseases and highlighting their potential for future trends and practical clinical applications.
Article
Biochemistry & Molecular Biology
Claudia Bonechi, Fariba Fahmideh Mahdizadeh, Luigi Talarico, Simone Pepi, Gabriella Tamasi, Gemma Leone, Marco Consumi, Alessandro Donati, Agnese Magnani
Summary: Glaucoma, a group of neurodegenerative diseases, is the second leading cause of irreversible blindness worldwide. The limited penetration of drugs through the ocular barrier reduces the systemic bioavailability, leading to the need for frequent drug administration and potential toxic effects. Liposomes and other novel drug-delivery systems can enhance the therapeutic efficacy of antiglaucomatous drugs by improving drug penetration, bioavailability, sustained release, tissue targeting, and reduction in intraocular pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Instruments & Instrumentation
Onyinye J. Uwaezuoke, Pradeep Kumar, Viness Pillay, Yahya E. Choonara
Summary: In the past 30 years, research on protein-resistant biomaterials targeted at designing bio-inert surfaces has been increasing. However, the results have been minimal, and the ideal anti-fouling biomaterial remains elusive. The field of implantable ocular devices has not seen as much research in this area, but the need for anti-fouling biomaterials is becoming increasingly apparent.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Materials Science, Biomaterials
Jiansheng Liu, Xueqin Qing, Qin Zhang, Ningyue Yu, Mengbin Ding, Zhaohui Li, Zhen Zhao, Zhiling Zhou, Jingchao Li
Summary: This study introduces an oxygen-producing proenzyme hydrogel for photodynamic therapy of breast cancer, which effectively inhibits tumor growth and metastasis. The hydrogel, composed of MnO2 nanoparticles and proenzyme nanoparticles, generates singlet oxygen to promote PDT and trigger cascade activation of proenzymes for cancer cell death upon photoactivation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Biotechnology & Applied Microbiology
Sean Swetledge, Jangwook P. Jung, Renee Carter, Cristina Sabliov
Summary: Polymeric nanoparticles as drug delivery systems offer advantages such as controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. However, their properties, administration route, and suspension media can impact their distribution and effectiveness in the eye, requiring careful design for specific target tissues and ocular diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Charis Rousou, Carl C. L. Schuurmans, Arto Urtti, Enrico Mastrobattista, Gert Storm, Chrit Moonen, Kai Kaarniranta, Roel Deckers
Summary: This review discusses the use of ultrasound and microbubbles for ocular drug delivery, focusing on enhancing efficacy by disrupting the blood-retina barrier, inducing cellular uptake, and achieving targeted delivery of genes. Safety and tolerability aspects of USMB are also highlighted as crucial for clinical translation.
Article
Chemistry, Multidisciplinary
Liangbo Chen, Feng Wu, Yan Pang, Dan Yan, Siyi Zhang, Fangjie Chen, Nianxuan Wu, Danni Gong, Jinyao Liu, Yao Fu, Xianqun Fan
Summary: The study demonstrates the formation of a durable and protective therapeutic nanocoating on the ocular surface by instilling biomimetic drug-loaded nanoparticles, which can specifically bind to ocular epithelium fibronectin and improve the stability of tear film. This approach shows therapeutic benefits in mouse and rabbit models of dry eye disease, indicating the potential of therapeutic nanocoating to treat eye diseases.
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Review
Biochemistry & Molecular Biology
Ta-Hsin Tsung, Yu-Chien Tsai, Hsin-Pei Lee, Yi-Hao Chen, Da-Wen Lu
Summary: Ocular drug delivery is a challenging field due to anatomical and physiological barriers of the eye. Biodegradable polymers have shown promise for efficient and controlled drug delivery in ocular diseases. This review provides an overview of biodegradable polymer-based drug-delivery systems for various ocular diseases, highlighting their potential for sustained drug release, improved bioavailability, and targeted therapy. The safety considerations and future directions of this field are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Su Yin Chaw, Wisna Novera, Ann-Marie Chacko, Tina Tzee Ling Wong, Subbu Venkatraman
Summary: Subconjunctival administration of nanocarriers can enhance drug bioavailability in specific parts of the eye by overcoming blood-ocular barriers. Different characteristics of liposomes (charge, size, cholesterol content, and lipid saturation) influence their distribution in ocular and corporeal tissues. Optimizing liposome design is necessary to control the temporal and spatial bioavailability and clearance of nanocarriers from the eye, improving the efficacy and safety of ocular therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Sofia M. Saraiva, Lucia Martin-Banderas, Matilde Duran-Lobato
Summary: The interest in using cannabinoids for medical applications, especially in treating eye conditions, has been growing. However, due to the unfavorable properties of cannabinoids and barriers for local administration in the eye, drug delivery systems are needed. This review focuses on identifying eye diseases that could be treated with cannabinoids, reviewing formulation properties, evaluating cannabinoid-based formulations for ocular administration, and exploring potential alternative formulations for eye administration.
Review
Biochemistry & Molecular Biology
Li-Ching Liu, Yi-Hao Chen, Da-Wen Lu
Summary: Ocular diseases have a significant impact on patients' vision and quality of life worldwide, but the unique anatomical and physiological barriers in the eye make effective drug delivery challenging. This comprehensive review provides an overview of various nano-based drug delivery systems for ocular applications, discussing their biology, methodology, clinical applications, and recent studies highlighting advantages and challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Onyinye Uwaezuoke, Lisa C. Du Toit, Pradeep Kumar, Naseer Ally, Yahya E. Choonara
Summary: This study investigated the potential use of transferosomes for delivering cyclosporine A to the eye. Linoleic acid was found to improve the stability and size of the transferosomes. Tween(R)-based formulation was preferred due to its lower toxicity profile. The prepared transferosomes showed significant drug release and adequate corneal permeability, remaining stable for four months at low temperature.
Review
Pharmacology & Pharmacy
Xiaojun Wang, Fuxiao Luan, Hua Yue, Cui Song, Shuang Wang, Jing Feng, Xiao Zhang, Wei Yang, Yuxin Li, Wei Wei, Yong Tao
Summary: Due to the complexity of ocular diseases and the natural ocular barriers, drug therapy for these diseases has limitations. With the development of biotechnology, smart materials have been widely tested to treat ocular diseases. This review analyzes recent developments in smart materials and discusses future directions for clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biology
Alys E. Davies, Rachel L. Williams, Gaia Lugano, Serban R. Pop, Victoria R. Kearns
Review
Ophthalmology
Ying Chen, Victoria R. Kearns, Liangyu Zhou, Teresa Sandinha, Wai Ching Lam, David H. Steel, Yau Kei Chan
Summary: This review provides an overview of the use of silicone oil as a long-term tamponade agent in the treatment of complicated vitreoretinal diseases. It covers the chemical and physical properties of silicone oil, its indications and complications, particularly emulsification, as well as the mechanisms and risk factors for emulsification and strategies for its effective removal. The review also explores new formulations of silicone oil, including research into slow-release pharmacological agents within silicone oil, and alternatives being developed for long-term tamponade.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Jessica J. Eyre, Rachel L. Williams, Hannah J. Levis
EXPERIMENTAL EYE RESEARCH
(2020)
Article
Cell & Tissue Engineering
Shen Nian, Victoria R. Kearns, David S. H. Wong, Akash Bachhuka, Krasimir Vasilev, Rachel L. Williams, Wico W. Lai, Amy Lo, Carl M. Sheridan
Summary: This study evaluated the surface modification of expanded polytetrafluoroethylene (ePTFE) using n-heptylamine (HA) plasma polymer for subretinal transplantation in a non-dystrophic rat model. Functional epithelial monolayer formation was successful on HA-coated ePFTE, with potential applications in future clinical settings. Surgical optimization using Healon GV showed successful transplantation and minimal inflammatory response in Royal College of Surgeons rats.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Review
Ophthalmology
Mariantonia Ferrara, Gaia Lugano, Maria Teresa Sandinha, Victoria R. Kearns, Brendan Geraghty, David H. W. Steel
Summary: Studying the biomechanical properties of biological tissues is crucial for understanding disease pathogenesis and optimizing surgical procedures. This article comprehensively reviews the biomechanical properties of the retina, internal limiting membrane, and Bruch's membrane-choroidal complex, emphasizing their potential implications for clinical and surgical practice.
Article
Pharmacology & Pharmacy
Lucy A. Bosworth, Kyle G. Doherty, James D. Hsuan, Samuel P. Cray, Raechelle A. D'Sa, Catalina Pineda Molina, Stephen F. Badylak, Rachel L. Williams
Summary: The conjunctiva, a critical tissue for eye protection and homeostasis, can be impaired by diseases requiring surgical intervention. A tissue engineering approach using PCL and UBM scaffolds showed potential for inducing stratification of human conjunctival epithelial cells. Further investigation is needed for these matrix-containing scaffolds as a potential therapy for conjunctival repair and regeneration.
Review
Biochemistry & Molecular Biology
Xiaochen Fan, Emine K. Bilir, Olivia A. Kingston, Rachel A. Oldershaw, Victoria R. Kearns, Colin E. Willoughby, Carl M. Sheridan
Summary: Glaucoma is a common eye disease characterized by irreversible optic nerve damage and progressive vision loss. Lowering intraocular pressure is crucial in treating glaucoma, and maintaining the structure and function of the trabecular meshwork cells is key to preventing elevated intraocular pressure. Cell transplantation is a potential treatment option for glaucoma, but challenges remain in developing a successful cell replacement approach.
Article
Materials Science, Biomaterials
Lap Tak Hung, Stephanie Hiu Ling Poon, Wing Huen Yan, Rebecca Lace, Liangyu Zhou, Jasper Ka Wai Wong, Rachel L. Williams, Kendrick Co Shih, Ho Cheung Shum, Yau Kei Chan
Summary: A strategy using a biocompatible polymer-based liquid-liquid interface has been developed for the rapid fabrication of scaffold-free corneal tissue constructs. The formed constructs exhibit essential physiological markers, preserved viability and proliferative ability, and can repair corneal epithelial wounds in vitro.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Robert C. Deller, Man Li, Kyle G. Doherty, Jenny Aveyard, Rachel L. Williams, Keli N. Kolegraff, Stephen B. Kaye, Raechelle A. D'Sa
Summary: The skin is an important barrier against environmental insults and pathogens, but injury or skin disorders can compromise its function, leading to bacterial colonization and infection. Bacterial proteases secreted by Staphylococcus aureus disturb wound healing and barrier integrity. This study demonstrates that a nitric oxide-releasing hydrogel can prevent loss of barrier function caused by S. aureus proteases, reducing microbial burden and inactivating proteases.
ADVANCED MATERIALS INTERFACES
(2023)
Meeting Abstract
Cell & Tissue Engineering
Xiaochen Fan, Emine Bilir, Stephnie Kennedy, Victoria Kearns, Colin Willoughby, Carl Sheridan
TISSUE ENGINEERING PART A
(2022)
Article
Chemistry, Physical
Man Li, Jenny Aveyard, Kyle G. Doherty, Robert C. Deller, Rachel L. Williams, Keli N. Kolegraff, Stephen B. Kaye, Raechelle A. D'Sa
Summary: Nonhealing and chronic wounds are a significant problem affecting patients' quality of life and healthcare systems. This paper introduces NO-releasing electrospun membranes as a potential alternative to antibiotics for the healing of chronic and infected wounds.
Article
Medicine, Research & Experimental
Bhumika Singh, Mohamed Essameldin Abdelgawad, Zulfiqur Ali, Jarrod Bailey, Elisa Budyn, Prospero Civita, Martin J. D. Clift, John T. Connelly, Samuel Constant, Marius Hittinger, Helena Kandarova, Victoria Rosalind Kearns, Tony Kiuru, Tomasz Kostrzewski, Sebastian Kress, Victoria Marsh Durban, Claus-Michael Lehr, Hayley McMillan, Julia Katharina Metz, Vivian Monteban, Dania Movia, Catia Neto, Carla Owen, Lauri Paasonen, Kerri Anne Palmer, Geoffrey John Pilkington, Karen Pilkington, Adriele Prina-Mello, Clive Roper, Jonathan Sheard, Sheree Smith, Janette Ellen Turner, Ipsita Roy, Melissa Anne Tutty, Eirini Velliou, John Malcolm Wilkinson
Summary: Replicating human physiology faithfully at cellular, tissue, and organ level is crucial for the development of effective and safe therapies. This requires collaboration and contributions from experts in various fields. The ACTC conference brought together professionals to share and discuss the latest developments in cell and tissue culture.
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
(2021)
Article
Chemistry, Multidisciplinary
Edyta Niezabitowska, Adam R. Town, Bassem Sabagh, Marissa D. Morales Moctezuma, Victoria R. Kearns, Sebastian G. Spain, Steve P. Rannard, Tom O. McDonald
NANOSCALE ADVANCES
(2020)
Meeting Abstract
Ophthalmology
Victoria Rosalind Kearns, Alys Davies, Helen Cauldbeck, Steve Rannard, Rachel Williams, Yau Kei Chan, Ho Cheung Shum
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)