Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 10, Issue 6, Pages 705-711Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2014.910119
Keywords
DC; dendritic cell; immunotherapy; ovarian cancer; uterine cancer; Wilms' tumor gene 1; WT1
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Pelvic gynecological malignancies account for 6% of all cancers. In the relapsed state, classical treatments are limited. There is an urgent need for new and personalized treatment. Wilms' tumor gene 1 (WT1) is the most important tumor-associated antigen. Although highly present in gynecological tumors, active immunotherapy against it is still underexplored. This review gives an insight into the importance of WT1 in pelvic gynecological malignancies and the first taken steps into the world of WT1 immunotherapy.
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