4.3 Article

Intravenous golimumab in rheumatoid arthritis

Journal

EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 10, Issue 7, Pages 823-830

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2014.918847

Keywords

anti-TNF- antibodies; golimumab; rheumatoid arthritis treatment; safety of TNF- inhibition; TNF- inhibition

Categories

Funding

  1. Abbott Laboratories
  2. Amgen
  3. AstraZeneca Pharmaceuticals
  4. Bristol-Meyers Squibb
  5. F. Hoffman LaRoche
  6. Genentech
  7. Janssen
  8. Johnson and Johnson
  9. Merck/Schering Plough
  10. Novartis
  11. Pfizer
  12. UCB
  13. Wyeth

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Intravenous golimumab in a dosage of 2 mg/kg, initially given every 4 weeks but then every 8 weeks, in addition to methotrexate, is effective in the treatment of patients with rheumatoid arthritis. This weight-based infusion is administered over thirty minutes with an acceptable safety profile. Since it is a relatively new formulation, more time will be required to assess its specific role in the rheumatologists' armamentarium and to appreciate more fully its long-term safety.

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