Update on the genetic risk factors for rheumatoid arthritis

Novel Association of the Interleukin 2–Interleukin 21 Region With Inflammatory Bowel Disease

(2009) Ana Márquez et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

CTLA4/ICOSgene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population

(2009) Erin J. Walker et al.   ARTHRITIS AND RHEUMATISM

Association of a single-nucleotide polymorphism inCD40with the rate of joint destruction in rheumatoid arthritis

(2009) Michael P. M. van der Linden et al.   ARTHRITIS AND RHEUMATISM

Variants inTNFAIP3,STAT4, andC12orf30loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

(2009) Sampath Prahalad et al.   ARTHRITIS AND RHEUMATISM

Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: All alleles are important

(2009) Emeli Lundström et al.   ARTHRITIS AND RHEUMATISM

Confirmation ofSTAT4,IL2/IL21, andCTLA4polymorphisms in rheumatoid arthritis

(2009) Nina A. Daha et al.   ARTHRITIS AND RHEUMATISM

Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis

(2009) H. M. Albers et al.   ARTHRITIS AND RHEUMATISM

Genetic risk factors for rheumatoid arthritis differ in caucasian and Korean populations

(2009) Hye-Soon Lee et al.   ARTHRITIS AND RHEUMATISM

Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region

(2009) Bo Ding et al.   ARTHRITIS AND RHEUMATISM

Association of the TRAF1/C5 locus with increased mortality, particularly from malignancy or sepsis, in patients with rheumatoid arthritis

(2009) Vasileios F. Panoulas et al.   ARTHRITIS AND RHEUMATISM

Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci

(2009) Charlotte Vignal et al.   ARTHRITIS AND RHEUMATISM

The NF- B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas

(2009) U. Novak et al.   BLOOD

Impaired development of human Th1 cells in patients with deficient expression of STAT4

(2009) H.-C. Chang et al.   BLOOD

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

(2009) E A M Festen et al.   GUT

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF- B signalling

(2009) G. Trynka et al.   GUT

Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes

(2009) Anne Barton et al.   HUMAN MOLECULAR GENETICS

Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23

(2009) Gisela Orozco et al.   HUMAN MOLECULAR GENETICS

The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype

(2009) B. Rueda et al.   HUMAN MOLECULAR GENETICS

Common and different genetic background for rheumatoid arthritis and coeliac disease

(2009) Marieke J.H. Coenen et al.   HUMAN MOLECULAR GENETICS

Genetics of rheumatoid arthritis: Underlying evidence of ethnic differences

(2009) Yuta Kochi et al.   JOURNAL OF AUTOIMMUNITY

TNFAIP3(A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

(2009) Roland Schmitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Value of HLA-DRB1 Shared Epitope, -308 Tumor Necrosis Factor-  Gene Promoter Polymorphism, Rheumatoid Factor, Anti-Citrullinated Peptide Antibodies, and Early Erosions for Predicting Radiological Outcome in Recent-Onset Rheumatoid Arthritis

(2009) S. RENESES et al.   JOURNAL OF RHEUMATOLOGY

Rheumatoid arthritis

(2009) Lars Klareskog et al.   LANCET

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Frequent inactivation of A20 in B-cell lymphomas

(2009) Motohiro Kato et al.   NATURE

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

(2009) Peter K Gregersen et al.   NATURE GENETICS

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

(2009) Melanie Bahlo et al.   NATURE GENETICS

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

6q23 polymorphisms in rheumatoid arthritis Spanish patients

(2009) N. Perdigones et al.   RHEUMATOLOGY

Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility

(2009) Rebeca Dieguez-Gonzalez et al.   ARTHRITIS RESEARCH & THERAPY

An African Ancestry-Specific Allele of CTLA4 Confers Protection against Rheumatoid Arthritis in African Americans

(2009) James M. Kelley et al.   PLoS Genetics

The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis

(2008) H M Albers et al.   ANNALS OF THE RHEUMATIC DISEASES

Association ofSTAT4with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population

(2008) Shu Kobayashi et al.   ARTHRITIS AND RHEUMATISM

Association ofSTAT4with rheumatoid arthritis: A replication study in three European populations

(2008) Gisela Orozco et al.   ARTHRITIS AND RHEUMATISM

ThePTPN22620W allele confers susceptibility to systemic sclerosis: Findings of a large case–control study of European Caucasians and a meta‐analysis

(2008) P. Dieudé et al.   ARTHRITIS AND RHEUMATISM

Association of the TRAF1–C5 locus on chromosome 9 with juvenile idiopathic arthritis

(2008) Edward M. Behrens et al.   ARTHRITIS AND RHEUMATISM

Progression of joint damage in early rheumatoid arthritis: Association with HLA–DRB1, rheumatoid factor, and anti–citrullinated protein antibodies in relation to different treatment strategies

(2008) J. K. de Vries-Bouwstra et al.   ARTHRITIS AND RHEUMATISM

Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate

(2008) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases

(2008) A. Martínez et al.   ARTHRITIS AND RHEUMATISM

Replication of the tumor necrosis factor receptor−associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study

(2008) F. A. S. Kurreeman et al.   ARTHRITIS AND RHEUMATISM

Genome-wide association study of rheumatoid arthritis in the Spanish population:KLF12as a risk locus for rheumatoid arthritis susceptibility

(2008) Antonio Julià et al.   ARTHRITIS AND RHEUMATISM

Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease

(2008) Beate Skinningsrud et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

(2008) E Y M G Fung et al.   GENES AND IMMUNITY

Variant form of STAT4 is associated with primary Sjögren's syndrome

(2008) B D Korman et al.   GENES AND IMMUNITY

STAT4: A risk factor for type 1 diabetes?

(2008) Maria I. Zervou et al.   HUMAN IMMUNOLOGY

Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population

(2008) Maria I. Zervou et al.   HUMAN IMMUNOLOGY

Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility

(2008) Anne Barton et al.   HUMAN MOLECULAR GENETICS

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

(2008) S. Sigurdsson et al.   HUMAN MOLECULAR GENETICS

Familial disease, the HLA-DRB1 shared epitope and anti-CCP antibodies influence time at appearance of substantial joint damage in rheumatoid arthritis

(2008) Adriana Rojas-Villarraga et al.   JOURNAL OF AUTOIMMUNITY

A20: Central Gatekeeper in Inflammation and Immunity

(2008) Beatrice Coornaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unknown

(2008) Hye-Soon Lee et al.   MOLECULAR MEDICINE

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

(2008) Jason D Cooper et al.   NATURE GENETICS

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

(2008) Anne Barton et al.   NATURE GENETICS

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

(2008) Soumya Raychaudhuri et al.   NATURE GENETICS

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

(2008) Stacy L Musone et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Detecting shared pathogenesis from the shared genetics of immune-related diseases

(2008) Alexandra Zhernakova et al.   NATURE REVIEWS GENETICS

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

(2008) Deborah J. Smyth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis

(2008) V. Goeb et al.   RHEUMATOLOGY

Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis

(2008) S. M. J. Harney et al.   RHEUMATOLOGY

Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects

(2008) Bernadett Farago et al.   RHEUMATOLOGY INTERNATIONAL

New classification of HLA-DRB1 alleles in Rheumatoid Arthritis susceptibility: a combined analysis of worldwide samples

(2008) Thomas Barnetche et al.   ARTHRITIS RESEARCH & THERAPY

T cells in rheumatoid arthritis

(2008) Andrew P Cope   ARTHRITIS RESEARCH & THERAPY

Control of autoimmune diseases by the vitamin D endocrine system

(2008) Luciano Adorini et al.   Nature clinical practice. Rheumatology

A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2

(2008) Monica Chang et al.   PLoS Genetics

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

(2008) Ying Liu et al.   PLoS Genetics

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology