Article
Oncology
Hope M. Guzzo, Stephanie A. Valente, Graham S. Schwarz, Ayat ElSherif, Stephen R. Grobmyer, Cagri Cakmakoglu, Risal Djohan, Steven Bernard, Julie E. Lang, Debra Pratt, Zahraa Al-Hilli
Summary: The study evaluated the safety and recurrence rates of immediate lymphatic reconstruction (ILR) in breast cancer patients undergoing axillary lymph node dissection (ALND). The results showed that ILR during ALND was not associated with short-term axillary recurrence and appeared to be oncologically safe.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Medicine, General & Internal
Ilhan Tasdoven, Hakan Balbaloglu, Rabiye Uslu Erdemir, Burak Bahadir, Cakmak Guldeniz Karadeniz
Summary: Axillary staging is an important issue in the management of breast cancer. This study used triple mapping to assess the metastatic involvement of axillary reverse mapping (ARM) nodes after neoadjuvant systemic therapy (NST). The results showed a significant overlap between arm and breast draining nodes, which may explain the development of lymphedema in patients even after treatment.
Article
Oncology
Ji Young You, Eun Sook Lee, Siew Kuan Lim, Youngmee Kwon, So-Youn Jung
Summary: According to the study, performing sentinel lymph node biopsy (SLNB) without axillary lymph node dissection (ALND) may be a reasonable treatment option for patients with positive lymph nodes after breast cancer surgery. There was no significant difference in the loco-regional recurrence rates between SLNB with ALND and SLNB alone.
FRONTIERS IN ONCOLOGY
(2023)
Review
Surgery
Nur Amalina Che Bakri, Richard M. Kwasnicki, Naairah Khan, Omar Ghandour, Alice Lee, Yasmin Grant, Aleksander Dawidziuk, Ara Darzi, Hutan Ashrafian, Daniel R. Leff
Summary: This study evaluated the impact of axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) on upper limb morbidity in breast cancer patients. The results showed that ALND patients had higher prevalence of lymphedema, pain, reduced strength, and range of motion compared with SLNB patients. These findings support the continued de-escalation of axillary surgery.
Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Ian Campbell, Neil Wetzig, Owen Ung, David Espinoza, Gelareh Farshid, John Collins, James Kollias, Val Gebski, Rebecca Mister, R. John Simes, Martin R. Stockler, Grantley Gill
Summary: For early breast cancer patients who are clinically node-negative, sentinel node-based management (SNBM) is the international standard of care. In the SNAC1 study, we report the rates of axillary recurrence, overall survival, and breast cancer-specific survival at 10 years.
Article
Medicine, General & Internal
Kelsey Lipman, Anna Luan, Kimberly Stone, Irene Wapnir, Mardi Karin, Dung Nguyen
Summary: This study highlights the LYMPHA technique as a feasible and effective method for prevention of lymphedema. By performing lymphatic mapping and lymphaticovenous anastomosis during the primary surgery, the morbidity associated with lymphedema can be avoided. A retrospective review showed successful prevention of lymphedema with minimal surgical complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Se Hyun Oh, Ju Hyeon Kim, Seung Tae Seong, Jun Young Park, Jae Hyun Lee, Ghi Chan Kim, Ho Joong Jeong, Young Joo Sim
Summary: This study investigated the impact of axillary site radiation therapy on lymphoscintigraphy in breast cancer-related lymphedema patients who underwent sentinel lymph node dissection. The results suggest that both SLND and aRTx affect the activity of axillary lymph nodes and adversely affect lymphatic flow, becoming risk factors for lymphedema. Additionally, lymphedema may develop even in patients with normal lymphoscintigraphy.
Article
Oncology
Jing Si, Rong Guo, Huan Pan, Xiang Lu, Zhiqin Guo, Chao Han, Li Xue, Dan Xing, Wanxin Wu, Caiping Chen
Summary: The aim of this study was to determine whether breast cancer patients with mastectomy and false-negative frozen section in sentinel lymph node biopsy (SLNB) could forgo axillary lymph node dissection (ALND). The study found that SLNB and axillary radiation therapy could effectively replace ALND in selected patients who met specific criteria.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lotte Poulsen, Manraj Kaur, Amalie L. Jacobsen, Mie P. Bjarnesen, Anna P. Bjarnesen, Anne F. Klassen, Andrea L. Pusic, Claire E. E. de Vries, Jens A. Sorensen
Summary: This study aimed to assess the impact of SLND and ALND on the HRQOL in women diagnosed with BCRL, and found no significant difference in the LYMPH-Q UE module scales between the two groups.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Massimiliano Gennaro, Chiara Listorti, Luigi Mariani, Marco Maccauro, Giulia Bianchi, Giuseppe Capri, Ilaria Maugeri, Laura Lozza, Maria Carmen De Santis, Secondo Folli
Summary: In this study, we followed up on 100 consecutive axillary node-positive patients treated with ARM-SAD and found a low rate of axillary failure, indicating that the ARM-SAD procedure is oncologically safe.
Article
Oncology
Gilles Houvenaeghel, Monique Cohen, Pedro Raro, Jeremy De Troyer, Pierre Gimbergues, Christine Tunon de Lara, Vivien Ceccato, Veronique Vaini-Cowen, Christelle Faure-Virelizier, Frederic Marchal, Tristan Gauthier, Eva Jouve, Pierrick Theret, Claudia Regis, Philippe Gabelle, Julia Pernaut, Francesco Del Piano, Gauthier D'Halluin, Stephane Lantheaume, Emile Darai, Bassoodeo Beedassy, Caroline Dhainaut-Speyer, Xavier Martin, Sophie Girard, Richard Villet, Emilie Monrigal, Theophile Hoyek, Jean-Francois Le Brun, Pierre-Emmanuel Colombo, Agnes Tallet, Jean-Marie Boher
Summary: The study analyzed the treatment and pathological results of patients included in the SERC trial, a multicenter randomized non-inferiority phase-3 trial comparing completion axillary lymph node dissection (cALND) with sentinel lymph node biopsy alone in breast cancer patients. Patients with one or two involved sentinel nodes by micro- or macro-metastases may not require cALND, but further research is needed for those with more than two involved nodes.
Article
Oncology
Massimiliano Gennaro, Marco Maccauro, Luigi Mariani, Chiara Listorti, Carmela Sigari, Annarita De Vivo, Marco Chisari, Ilaria Maugeri, Alice Lorenzoni, Gianluca Aliberti, Gianfranco P. Scaperrotta, Augusto Caraceni, Giancarlo Pruneri, Secondo Folli
Summary: This study confirms that axillary reverse mapping and selective axillary dissection (ARM-SAD) can reduce the risk of breast-cancer-related lymphedema (BCRL) in patients with node-positive breast cancer, compared to standard axillary dissection (AD). ARM-SAD showed significantly lower incidence of BCRL in multiple assessments, including physiatrist's findings, excess arm volume, and lymphoscintigraphic findings, although there was no significant difference in patients' self-reports.
Article
Oncology
Anna C. Beck, Monica Morrow
Summary: Although sentinel lymph node biopsy is the preferred method for axillary staging and therapeutic for limited nodal disease, axillary lymph node dissection is still necessary in certain cases and for maintaining local control with heavy axillary tumor burden. Knowledge of the number of involved axillary nodes, obtained through axillary lymph node dissection, is also needed for tailored systemic therapies. Ongoing trials will explore the possibility of radiotherapy as a replacement for axillary lymph node dissection in certain circumstances.
Article
Oncology
Qianqian Yuan, Jinxuan Hou, Yukun He, Yiqian Liao, Lewei Zheng, Gaosong Wu
Summary: ALND based on BLL can minimize surgical extent for node-positive breast cancer patients, potentially reducing the occurrence of BCRL.
