Article
Pharmacology & Pharmacy
Wei Xiao, Zehui He, Weikang Luo, Dandan Feng, Yang Wang, Tao Tang, Ali Yang, Jiekun Luo
Summary: Intracerebral hemorrhage (ICH) induces inflammatory response that affects brain repair and organism recovery. Research suggests that Buyang Huanwu Decoction (BYHWD) can attenuate the inflammatory response during ICH recovery in rats by inhibiting the NIK-mediated noncanonical NF-kappa B signaling pathway, improving neurological function in rats.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Sevval Nur Bilgic, Aylin Domaniku, Batu Toledo, Samet Agca, Bahar Z. C. Weber, Dilsad H. Arabaci, Zeynep Ozornek, Pascale Lause, Jean-Paul Thissen, Audrey Loumaye, Serkan Kir
Summary: Skeletal muscle atrophy is a common problem in patients with cancer, leading to poor survival and reduced quality of life. The mechanisms behind this muscle wasting are still not fully understood, making it difficult to develop effective therapies.
Article
Oncology
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Summary: This study confirmed that cytoplasmic protein TRAF2 can be methylated by SMYD2 and contribute to the continuous activation of NF-kappa B signaling pathway. Knocking down SMYD2 showed varying degrees of mitigation in acute and chronic inflammation mouse models. Moreover, lysine-specific demethylase LSD1 was found to resist the methylation of TRAF2 induced by SMYD2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Dongfang Dai, Hongping Zhou, Li Yin, Fei Ye, Xiao Yuan, Tao You, Xiaohui Zhao, Weiguo Long, Deqiang Wang, Xia He, Jifeng Feng, Deyu Chen
Summary: PELI1 regulates the sensitivity of tumor cells to radiotherapy by modulating the expression of noncanonical NF-kappa B induced by IR, ultimately promoting apoptosis in tumor cells.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xue Liang, Jiping Yao, Danrui Cui, Weiyang Zheng, Yanning Liu, Guohua Lou, Bingjue Ye, Liyan Shui, Yi Sun, Yongchao Zhao, Min Zheng
Summary: This study investigated the dysregulation of TRAF2 in liver cancer and its biological function, aiming to validate TRAF2 as a promising therapeutic target for liver cancer.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Medicine, Research & Experimental
Yingke Zhou, Xin Jin, Haixin Yu, Gengdu Qin, Penglin Pan, Jingyuan Zhao, Taoyu Chen, Xueyi Liang, Yan Sun, Bo Wang, Dianyun Ren, Shikai Zhu, Heshui Wu
Summary: This study reveals the role of HDAC5 in regulating the NF-KB signaling pathway and antitumor immune responses in PDAC. HDAC5 downregulation is associated with favorable prognosis in PDAC patients. HDAC5 regulates PD-L1 expression by interacting with NF-KB p65 and its inhibition sensitizes PDAC tumors to immune checkpoint blockade therapy.
Review
Gastroenterology & Hepatology
Qianhui Chen, Xinyu Lu, Xiaoyong Zhang
Summary: The noncanonical NF-kappa B signaling pathway plays a crucial role in regulating inflammation and immune response, showing potential therapeutic value against liver diseases. Activation of this pathway may contribute to viral clearance, with specific inhibitors and antibodies currently under development and testing.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Review
Oncology
John Silke, Lorraine Ann O'Reilly
Summary: Pancreatic Ductal Adenocarcinoma (PDAC) is a deadly cancer with increasing incidence and limited treatment options, necessitating the development of new therapeutic approaches. NF-kappa B pathways play a critical role in pancreatic injury, tumor progression, and drug resistance, but its dysregulation can also inhibit inflammation and cancer depending on the context. The role of individual components of the NF-kappa B pathway in PDAC microenvironment is complex and stage-dependent.
Article
Veterinary Sciences
Xiao Liu, Yanan Zhu, Dan Wang, Ran Feng, Zhihao Chen, Zifang Zheng, Yang Li, Lele Xu, Haixue Zheng, Yunpeng Fan, Yupeng Yin, Shuqi Xiao
Summary: By screening natural compounds, researchers discovered that Sanggenon C (SC) can inhibit the infection of porcine reproductive and respiratory syndrome virus (PRRSV) and protect cells from damage. The mechanism involves regulating the TRAF2/NF-kappa B signaling pathway to reduce viral replication. This study contributes to the understanding of therapeutic targets and pathogenesis in PRRSV infection.
VETERINARY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Baptiste Dumetier, Aymeric Zadoroznyj, Jean Berthelet, Sebastien Causse, Jennifer Allegre, Pauline Bourgeois, Florine Cattin, Cindy Racoeur, Catherine Paul, Carmen Garrido, Laurence Dubrez
Summary: Cellular inhibitor of apoptosis-1 (cIAP1) is a signaling regulator involved in the regulation of multiple signaling pathways and has oncogenic properties. It interacts with the molecular adaptor TRAF2 to form signaling complexes and promotes tumor growth through the activation of the JAK/STAT3 pathway.
Article
Virology
Thomas Charles Bisom, Hope Smelser, Jean-Marc Lanchy, J. Stephen Lodmell
Summary: The noncanonical NF-κB pathway, originally involved in lymphoid organogenesis, has shown increased importance in innate immunity in the past 20 years. RNA viruses have been found to activate and exploit this pathway, especially in disrupting transcription of type 1 interferon. This study demonstrates that alternative splicing of RIOK3 mRNA is associated with activation of the noncanonical NF-κB pathway, which is co-opted by RVFV (MP12) to enhance viral success during infection.
Article
Chemistry, Medicinal
James J. Crawford, Jianwen Feng, Hans D. Brightbill, Adam R. Johnson, Matthew Wright, Aleksandr Kolesnikov, Wendy Lee, Georgette M. Castanedo, Steven Do, Nicole Blaquiere, Steven T. Staben, Po-Chang Chiang, Peter W. Fan, Matt Baumgardner, Susan Wong, Robert Godemann, Alice Grabbe, Catharina Wiegel, Swathi Sujatha-Bhaskar, Sarah G. Hymowitz, Nicholas Liau, Peter L. Hsu, Paul A. McEwan, Moulay Hicham Alaoui Ismaili, Matthew L. Landry
Summary: Clearance-driven optimization was conducted to improve the NIK inhibitor by utilizing metabolite identification studies and structure-based drug design. This resulted in the discovery of an azabicyclo[3.1.0]hexanone motif that reduced in vitro and in vivo clearance, maintained NIK potency, increased selectivity over other kinases, and achieved a more than ten-fold reduction in predicted human dose.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Cell Biology
Jun Xie, Ying Du, Dewang Liu, Jianfeng Wu, Kang Yang, Xiaoyu He, Jiayi Zhao, Peicheng Hong, Kunyu Liao, Huanrong Zhang, Yazhen Hong, John R. Teijaro, Seung Goo Kang, Changchun Xiao, Wen-Hsien Liu
Summary: The miR-17 similar to 92 family microRNAs play a key role in T cell and plasma cell differentiation. In this study, researchers found that the miR-17 similar to 92 family also has important functions in B cell differentiation and function, regulating the key target gene Socs3 in plasma cell differentiation.
Article
Oncology
Xianze Wang, Hao Chen, Rui Jiang, Xiafei Hong, Junya Peng, Wenyan Chen, Jialin Jiang, Jie Li, Dan Huang, Hongmei Dai, Wenze Wang, Junliang Lu, Yupei Zhao, Wenming Wu
Summary: The study confirmed the pro-tumor effects of IL-17 and Notch pathways in PanIN/PDAC progression and identified a positive correlation between IL-17 and Notch. Furthermore, co-inhibition of IL-17 and Notch pathways was shown to enhance therapeutic efficacy by restricting tumor growth.
Article
Biochemistry & Molecular Biology
Xiujuan Shi, Yongjia Hu, Yuxiong Jiang, Jiawen Wu, Chen Zhang, Jieping Zhang, Shengyu Wu, Yingshi Wu, Weibing Dong, Jue Li
Summary: In this study, it was found that Scutellarein significantly inhibited PE-induced cardiomyocyte hypertrophy and suppressed the expression of hypertrophic markers. Additionally, the attenuating effects of Scutellarein on cardiac hypertrophy may be mediated by suppressing the activity of the TRAF2/NF-kappa B signaling pathway.
MOLECULAR BIOLOGY REPORTS
(2022)
