Article
Urology & Nephrology
Matthew G. Parry, Arunan Sujenthiran, Julie Nossiter, Melanie Morris, Brendan Berry, Arjun Nathan, Ajay Aggarwal, Heather Payne, Jan van der Meulen, Noel W. Clarke
Summary: This observational cohort study examines the 5-year failure-free survival (FFS) of 1381 men who received high-intensity focused ultrasound (HIFU) for localized prostate cancer. The study finds that four in five men were free from local salvage treatment at 5 years, but treatment failure rates varied significantly based on ISUP Grade Group.
Article
Acoustics
Jordan B. Joiner, Nancy P. Kren, Phillip G. Durham, Autumn J. McRee, Paul A. Dayton, Yuliya Pylayeva-Gupta
Summary: Pancreatic adenocarcinoma is a highly aggressive tumor with limited treatment options and poor prognosis. This study investigated the potential of using focused ultrasound and microbubbles to modulate the tumor microenvironment and enhance the efficacy of immunotherapy in pancreatic adenocarcinoma. The results showed that the treatment induced changes in immune cells and tumor growth, indicating the potential of this approach for combination therapy. However, the effects were diminished in larger tumors, highlighting the need for further optimization.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Sung Kyu Hong, Hakmin Lee
Summary: PGA with HIFU is a safe and effective treatment option for clinically unilateral prostate cancer, providing satisfactory oncological control and preserving functional outcomes. Further prospective studies are needed to evaluate the oncological and functional outcomes of PGA with HIFU more accurately.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Review
Oncology
Petros X. E. Mouratidis, Gail ter Haar
Summary: Pancreatic cancer, with its low survival rates, presents a significant challenge in terms of treatment. Immunotherapy has shown promise in cancer treatment, but its effectiveness for pancreatic cancer patients is limited. Alternative treatment approaches to enhance the effectiveness of immunotherapy are needed. Therapeutic focused ultrasound, a non-invasive physical modality, can kill cancer cells and induce an anti-cancer immune response. Studies have shown that therapeutic focused ultrasound is a safe and effective technique for treating pancreatic cancer patients, improving survival rates.
Article
Oncology
Mu Yao Tsai, Chih Tai Lin, Ping Hsuan Chiang, Po Hui Chiang, Ping Chia Chiang
Summary: This study reported preliminary outcomes of high-intensity focused ultrasound (HIFU) in combination with transurethral resection of the prostate for localized prostate cancer in Taiwan. The results showed that HIFU treatment achieved adequate short-term cancer control, excellent potency, and continence preservation, with low complication rates.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Renske J. E. van den Bijgaart, Vera E. E. Mekers, Fabian Schuurmans, Tonke K. K. Raaijmakers, Melissa Wassink, Andor Veltien, Erik Dumont, Arend Heerschap, Jurgen J. J. Fuetterer, Gosse J. J. Adema
Summary: This study compared the immunomodulatory effects of thermal (T)-HIFU and mechanical (M)-HIFU ablation and found that M-HIFU significantly increased dendritic cell activation. Administration of CpG enhanced dendritic cell activation after both T- and M-HIFU ablation. Further experiments showed that M-HIFU generated tumor debris with fragmented RNA, DNA, and protein profiles, and lower levels of immunosuppressive cytokines compared to untreated tumor tissue or T-HIFU.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Junyong Dai, Yunfang Wu, Ziqun Chen, Linkang Xiao, Weili Zhang, Yang Cao
Summary: Prostate cancer is a common cancer type and early detection is crucial for successful treatment. This study presents a noninvasive imaging-guided therapy using targeted nanoparticles to enhance the efficacy and safety of cancer treatments. The modified sonosensitive nanoparticles can specifically accumulate in prostate tumors and release chemotherapy drugs in a controlled manner, providing a potential clinical treatment for prostate cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jian-zhou Cao, Rui Su, Jin-feng Pan, Ze-jun Yan, Qi Ma
Summary: The study proposed a hypothesis of using a combination of HIFU and bicalutamide as the first-line salvage therapy for local recurrent PCa, due to its minimal invasiveness, better quality of life, and the option to preserve radiotherapy as the second-line treatment. More clinical trials are needed to confirm the effectiveness of this approach in treating recurrent PCa.
FRONTIERS IN ONCOLOGY
(2021)
Article
Acoustics
Che-Chou Shen, Ri-Cheng Lin, Nien-Hung Wu
Summary: This study proposes a Golay-encoded ultrasound (US) monitoring method to address the difficulties in monitoring high-intensity focused ultrasound (HIFU) treatment caused by strong HIFU interference. By effectively removing HIFU interference patterns, this method improves the image quality metrics and increases the echo magnitude in real-time B-mode imaging. Experimental results show that Golay decoding significantly increases the PSNR of US monitoring images and improves the SSIM index, making the B-mode image with HIFU transmission visually indistinguishable from the one without HIFU transmission.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Acoustics
Tatiana D. Khokhlova, Yak-Nam Wang, Helena Son, Stephanie Totten, Stella Whang, Joo Ha Hwang
Summary: Pulsed high intensity focused ultrasound (pHIFU) is a non-invasive method that increases the permeability of pancreatic tumors to systemically administered drugs. In this study, the tolerability and effects of pHIFU-aided gemcitabine administrations on tumor progression and immune microenvironment were investigated in a mouse model of spontaneously occurring pancreatic tumors. The combination treatment of pHIFU and gemcitabine was well tolerated and led to significant downregulation of genes related to immunosuppression, tumorigenesis, and chemoresistance.
Article
Multidisciplinary Sciences
Brett Z. Fite, James Wang, Aris J. Kare, Asaf Ilovitsh, Michael Chavez, Tali Ilovitsh, Nisi Zhang, Weiyu Chen, Elise Robinson, Hua Zhang, Azadeh Kheirolomoom, Matthew T. Silvestrini, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, Ryan R. Davis, Clifford G. Tepper, Alexander D. Borowsky, Katherine W. Ferrara
Summary: High intensity focused ultrasound (HIFU) can rapidly and non-invasively destroy tumor tissue. A combination of HIFU with innate immune agonist CpG and checkpoint inhibitor anti-PD-1 can modulate the immune response, leading to enhanced anti-tumor effects. Both mechanical disruption HIFU and thermal ablation induce potent inflammatory responses, while priming with CpG can further enhance immune response, alter macrophage polarization, and increase T-cell activation.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Seok-Soo Byun, Noh Jin, Hakmin Lee
Summary: This study compared the clinical outcomes of whole gland ablation and partial gland ablation using high-intensity focused ultrasound for localized prostate cancer. The results showed that partial gland ablation had favorable clinical outcomes, including faster recovery of urinary incontinence and fewer adverse effects.
CLINICAL GENITOURINARY CANCER
(2022)
Article
Oncology
Sin Yuin Yeo, Grischa Bratke, Peter Knoell, Sebastian Gottfried Walter, David Maintz, Holger Gruell
Summary: Desmoid tumors are a rare form of cancer that can invade surrounding tissues and occur anywhere in the body. Treatment options include surgery, radiation therapy, chemotherapy, and thermal ablation with HIFU. This report presents a case of a desmoid tumor that was surgically resected twice and then treated with HIFU, leading to complete tumor remission and pain relief.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Biomedical
Molly Smallcomb, Julianna C. Simon
Summary: This study investigates ultrasonic atomization and erosion from planar healthy and tendinopathic tendon surfaces as we evaluate HIFU parameters for histotripsy in tendons. Results showed that tendons with chronic tendinopathies may be more susceptible than healthy tendons to erosion by HIFU atomization.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Review
Oncology
Sin Yuin Yeo, Grischa Bratke, Holger Gruell
Summary: High Intensity Focused Ultrasound (HIFU) is a non-invasive method for ablating tumors and treating painful bone lesions. It has been used for pain relief in bone metastases and primary tumors for 20 years, as well as for local treatment of bone tumors. This review summarizes 20 years of literature on HIFU treatment of bone malignancies, focusing on pain palliation, treatment efficacy, and safety.