Article
Ophthalmology
Hansell Soto, Randy C. Bowen, Vishal Raval, Gabrielle Yeaney, Arun Singh
Summary: This study assessed the role of map biopsy in patients with conjunctival primary acquired melanosis (PAM)/melanoma. The results showed that map biopsy enhances the overall assessment of the extent of the disease and impacts the use of topical chemotherapy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Beatrice Gallo, Caroline Thaung, Gordon Hay, Amit K. Arora, Victoria Ml Cohen, Bertil Damato, Mandeep S. Sagoo
Summary: This study reported four cases of conjunctival melanoma masquerading as ocular surface squamous neoplasia, highlighting the clinical resemblance between conjunctival melanoma and ocular surface squamous neoplasia and the importance of confirming clinical impressions histopathologically.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Cell Biology
Daja Sekoranja, Gregor Hawlina, Joze Pizem
Summary: PRAME expression was evaluated in various types of conjunctival melanocytic lesions, with most nevi showing no or only focal expression, while a high percentage of invasive melanomas and in-situ melanomas exhibited diffuse 4+ PRAME expression. This indicates that diffuse 4+ PRAME positivity is highly specific for malignant conjunctival melanocytic lesions and can aid in the diagnosis of suspected conjunctival melanoma.
Review
Medical Laboratory Technology
Scott C. Bresler, Caroline Simon, Carol L. Shields, Jonathan B. McHugh, Anna M. Stagner, Rajiv M. Patel
Summary: Conjunctival melanocytic lesions comprise a range of neoplastic and nonneoplastic conditions. Accurate histologic classification is crucial for diagnosing these lesions. This article provides an overview of different classification schemes and updates on molecular features and prognostic indicators.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Ophthalmology
Simone Nuessle, Claudia Auw-Haedrich, Jana Jiang, Daniel Boehringer, Thomas Reinhard
Summary: This study compared topical interferon alpha 2b (IFN-alpha 2b) to topical mitomycin C (MMC) in patients with primary acquired melanosis with atypia (PAM) and melanoma of the conjunctiva/cornea (CM). The results suggest that topical IFN-alpha 2b (arguably together with radiotherapy) may be a viable alternative to MMC, with fewer side effects and similar response rates.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Oncology
Maria Grazia Sammarco, Monica Maria Pagliara, Gustavo Savino, Federico Giannuzzi, Matteo Mario Carla, Carmela Grazia Caputo, Maria Antonietta Blasi
Summary: This study evaluated the efficacy of hyaluronic acid eye drops and hyaluronic acid-conjugated lactobionic acid eye drops as supportive therapy. The results showed that hyaluronic acid can improve ocular parameters and reduce adverse effects induced by mitomycin C.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Magdalena Debicka-Kumela, Bozena Romanowska-Dixon, Izabella Karska-Basta, Joanna Kowal, Weronika Pociej-Marciak, Anna Markiewicz
Summary: The algorithm developed in this study, based on modified dermatoscopic characteristics, is a valuable tool for diagnosing conjunctival melanoma.
ANTICANCER RESEARCH
(2021)
Article
Ophthalmology
Noemie Lauwers, Katleen Janssens, Michelle Mertens, Danny Mathysen, Martin Lammens, Rob J. W. de Keizer, Veva De Groot
Summary: AS-OCT and UBM measurements of tumor thickness showed significant positive correlation with HP; UBM measurements also correlated positively with HP; AS-OCT measurements only showed mild, non-significant positive correlation with HP. Both AS-OCT and UBM are useful imaging techniques for corneal and conjunctival bulbar tumors, but neither should be considered as replacements for HP.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
J. A. van Ipenburg, N. C. Naus, H. J. Dubbink, R. van Ginderdeuren, G. S. Missotten, D. Paridaens, R. M. Verdijk
Summary: The study evaluated prognostic factors in conjunctival melanomas (CM) and found that tumor characteristics like thickness, pT status, specific cell types, and mutations were correlated with metastasis. TERT promoter mutations were associated with shorter metastasis-free survival. Eyelid, fornix, and caruncular melanomas were more likely to recur. The majority of CM patients were treated with excision and adjuvant therapy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Tatyana Milman, Maya Eiger-Moscovich, Roger K. Henry, Robert Folberg, Sarah E. Coupland, Hans E. Grossniklaus, Hardeep Singh Mudhar, Charles G. Eberhart, Steffen Heegaard, Claudia Auw-Haedrich, Martina C. Herwig-Carl, Karin U. Loeffler, Svetlana Cherepanoff, Qiang Zhang, James E. Sharpe, Thonnie Rose O. See, Carol L. Shields, Ralph C. Eagle
Summary: This study compared the sensitivity, specificity, accuracy, and interobserver agreement of three classification systems for conjunctival melanocytic intraepithelial lesions, finding comparable strengths in identifying lesions with potential for recurrence. The simplified WHO classification scheme was deemed appropriate for evaluating these lesions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Veterinary Sciences
Vito Biondi, Annamaria Passantino, Michela Pugliese, Salvatore Monti, Alessandra Sfacteria, Simona Di Pietro
Summary: A five-year-old Arabian mare presented with an inverted papilloma progressing to squamous cell carcinoma on the conjunctiva of the right eye, with no local recurrence during the 12-month follow-up.
VETERINARY SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natasha M. van Poppelen, Jolique A. van Ipenburg, Quincy van den Bosch, Jolanda Vaarwater, Tom Brands, Bert Eussen, Frank Magielsen, Hendrikus J. Dubbink, Dion Paridaens, Erwin Brosens, Nicole Naus, Annelies de Klein, Emine Kilic, Robert M. Verdijk
Summary: This study aimed to explore the genetic background of conjunctival melanoma (CM) and its correlation with recurrent and metastatic disease. Various gene mutations were found, with TERT promoter mutations being associated with metastatic disease. About three quarter of CM cases contain drug-targetable mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Kelsey Vernon Stuart, Daniel John Shepherd, Amy Lombard, Roland Hollhumer, Mazvita Muchengeti
Summary: This study describes the incidence and epidemiology of conjunctival squamous cell carcinoma (CSCC) in South Africa over a 25-year period, with a particular focus on the HIV epidemic. The study identifies two distinct epidemiological patterns of CSCC and finds a decline in incidence rates since 2009, which is correlated with the widespread provision of antiretroviral therapy (ART). These findings have important implications for future incidence studies and public health policy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Tae Keun Yoo, Joon Yul Choi, Hong Kyu Kim, Ik Hee Ryu, Jin Kuk Kim
Summary: The study developed a low-shot deep learning model using GAN-based augmentation for conjunctival melanoma detection, achieving significant improvement in classification accuracy. Among the models tested, MobileNetV2 showed the highest accuracy in four-class classification and 3D melanoma phantom image detection, highlighting the potential of deep learning in ocular surface image analysis.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Ophthalmology
Puneet Jain, Paul T. Finger, Maria Fili, Bertil Damato, Sarah E. Coupland, Heinrich Heimann, Nihal Kenawy, Niels Brouwer, Marina Marinkovic, Sjoerd G. Van Duinen, Jean Pierre Caujolle, Celia Maschi, Stefan Seregard, David Pelayes, Martin Folgar, Yacoub A. Yousef, Hatem Krema, Brenda Gallie, Alberto Calle-Vasquez
Summary: This multicentre international study showed that the eighth edition of AJCC tumour staging was related to the risk of local recurrence of conjunctival melanoma after treatment. Despite current management, the 10-year cumulative local recurrence remains high.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivela, Ashwin Mallipatna, Chengyue Zhang, Junyang Zhao, Matthew Wilson, Rachel Brennan, Michala Burges, Jonathan Kim, Jesse L. Berry, Rima Jubran, Vikas Khetan, Suganeswari Ganeshan, Andrey Yarovoy, Vera Yarovaya, Elena Kotova, Denis Volodin, Yacoub Yousef, Kalle Nummi, Tatiana L. Ushakova, Olga Yugay, Vladimir G. Polyakov, Marco Antonio Ramirez-Ortiz, Elizabeth Esparza-Aguiar, Guillermo L. Chantada, Paula Schaiquevich, Adriana C. Fandino, Jason C. Yam, Winnie W. Lau, Carol P. Lam, Phillipa Sharwood, Sonia Moorthy, Quah Boon Long, Vera Adobea Essuman, Lorna A. Renner, Ekaterina Semenova, Jaume Catala-Mora, Maria Correa Llano, Elisa Carreras
Summary: This study analyzed data from 1054 RB eyes from 18 ophthalmic oncology centers worldwide and found that eyes with diffuse intraocular distribution of RB seeds had a higher risk of local treatment failure compared to eyes with focal seeds. Therefore, further subclassification of AJCC RB category cT2b into focal and diffuse seeds can improve prognostication for eye salvage.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Muhammed Jawad, Krishna Yamini, Ziyaad Sultan, Sarah Coupland, James Hsuan, Austin McCormick
Summary: This article presents a case of retained intraorbital grease, discussing the clinical and radiological findings, as well as the management approach.
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2023)
Article
Ophthalmology
Stine Dahl Vest, Sarah E. Coupland, Bita Esmaeli, Paul T. Finger, Gerardo F. Graue, Hans E. Grossniklaus, Tine Gadegaard Hindso, Frederik Holm, Santosh G. Honavar, Jwu Jin Khong, Marina Knudsen Kirkegaard, Penelope A. McKelvie, Lauge Hjorth Mikkelsen, Kaustubh Mulay, Peter Kristian Rasmussen, Volkert Siersma, Lene Dissing Sjo, Matthew C. Sniegowski, Bradley A. Thuro, Geeta K. Vemuganti, Steffen Heegaard
Summary: The specific location of ocular adnexal lymphoma (OAL) and the AJCC TNM tumour stage are prognostic factors for mortality in different OAL subtypes. Eyelid lymphoma has the highest disease-specific mortality in all subtypes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Katharina Eibenberger, Rumana Hussain, Yamini Krishna, Sarah E. Coupland, Heinrich Heimann
Review
Ophthalmology
Lindsay A. McGrath, David A. Ryan, Sunil K. Warrier, Sarah E. Coupland, William J. Glasson
Summary: Conjunctival lymphoma is an ocular malignancy derived from clonal proliferation of lymphocytes. The majority of cases are extranodal marginal zone B-cell lymphoma, but other subtypes also exist. Clinical manifestations are nonspecific, but typically present as painless conjunctival lesions. Treatment approaches focus on local immunomodulation. Recent advancements in sequencing technologies have improved clinicians' ability to predict disease recurrence and systemic involvement.
Article
Ophthalmology
James Draper, Jodi Alexander, Rohini M. Nair, Nicole Scullion, Revu V. L. Narayana, Karen Aughton, Geeta K. Vemuganti, Helen Kalirai, Sarah E. Coupland
Summary: This study aimed to investigate the effects of hypoxia on tumor growth and dissemination in uveal melanoma (UM), and found that hypoxia pre-conditioning does not drive a metastatic phenotype in UM.
CURRENT EYE RESEARCH
(2023)
Article
Medicine, General & Internal
Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Arman Rahman, Fiona O'Connell, Josep M. Piulats, Valerie O'Neill, Noel Horgan, Sarah E. Coupland, Jacintha O'Sullivan, William M. Gallagher, Alberto Villanueva, Breandan N. Kennedy
Summary: A study found that high expression of CysLT(1) is associated with poor prognosis in primary uveal melanoma (UM). Additionally, quininib and 1,4-dihydroxy quininib drugs were able to alter cancer hallmarks of UM cell lines in vitro. The study also highlighted the diagnostic and therapeutic potential of CysLT(1) and ATP5F1B in UM.
FRONTIERS IN MEDICINE
(2023)
Letter
Ophthalmology
Stephanie Lemaitre, Caroline Thaung, Sarah E. Coupland, Mandeep S. Sagoo
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2023)
Article
Ophthalmology
Alexander Wallace, Yamini Krishna, Sarah E. Coupland, Heinrich Heimann, Asterios Diafas, Rumana N. Hussain
Summary: This study reports a previously unrecognized clinical feature of choroidal melanoma, termed tumor-associated retinal pigmentation (TARP), which represents tumor-associated macrophages. This feature is associated with choroidal melanomas of high metastatic-risk clinical and genetic characteristics.
Article
Oncology
Helena Robinson, Antonio Eleuteri, Joseph J. Sacco, Rumana Hussain, Heinrich Heimann, Azzam F. G. Taktak, Bertil Damato, Alexander J. Thompson, Thomas Allen, Helen Kalirai, Sarah E. Coupland
Summary: This study compares the accuracy of different prognostic systems for targeting surveillance programs in uveal melanoma patients. It suggests that the Liverpool Uveal Melanoma Prognosticator Online III (LUMPOIII) offers greater specificity and provides guidance for its use. This study provides valuable information for revising the clinical guidelines for surveillance in uveal melanoma.
Article
Chemistry, Medicinal
Jie Yin, Gangyin Zhao, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Gabriel Forn-Cuni, Annemijn P. A. Wierenga, Martine J. Jager, B. Ewa Snaar-Jagalska, Arwin Groenewoud
Summary: Given the rarity of uveal melanoma and the lack of effective treatments, researchers have developed a method to collect and preserve limited tissue samples from primary tumors and metastases for advanced research and drug screening.
Article
Cell Biology
Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Felix B. Engel, B. E. Snaar-Jagalska
Summary: This study established a patient-derived animal model for metastatic UM and identified ferroptosis induction as a possible therapeutic strategy for the treatment of UM patients.
CELL DEATH DISCOVERY
(2023)
Editorial Material
Ophthalmology
Tatyana Milman, Hans E. Grossniklaus, Gabrielle Goldman-Levy, Tero T. Kivela, Sarah E. Coupland, Valerie A. White, Hardeep Singh Mudhar, Charles G. Eberhart, Robert M. Verdijk, Steffen Heegaard, Anthony J. Gill, Martine J. Jager, Aberlardo A. Rodriguez-Reyes, Bita Esmaeli, Jennelle C. Hodge, Ian A. Cree
Summary: The 5th edition of the WHO Classification of Tumours of the Eye and Orbit is a significant step in standardizing diagnostic practices globally. It introduces new chapters and consolidates sections, highlighting recent advances in etiology, pathogenesis, and diagnosis of eye and orbital tumors. This edition also includes updates on classification schemes and newly identified tumors. The editorial summarizes the major changes and specific updates in each taxonomic category, focusing on advances in understanding tumor pathogenesis, diagnostic criteria, and molecular markers.
OCULAR ONCOLOGY AND PATHOLOGY
(2023)
Review
Oncology
Mona Meng Wang, Sarah E. Coupland, Tero Aittokallio, Carlos R. Figueiredo
Summary: Immune checkpoint therapies can enhance the function of anti-tumour T cells and improve outcomes in cancer patients. However, some patients are refractory to this therapy due to "cold" tumours that do not allow T cell generation or the infiltration of existing anti-tumour T cells. This review explores the mechanisms by which cancer cells induce T cell "desertification" and "exclusion" in these refractory tumours, and highlights the importance of developing immunotherapies that restore T cell generation and tumour trafficking.
BRITISH JOURNAL OF CANCER
(2023)
Article
Genetics & Heredity
Philip Bland, Harry Saville, Patty T. Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E. Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N. Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Guy Pratt, Ceri Oldreive, Tatjana Stankovic, Samantha Barlow, Helen Kalirai, Sarah E. Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti S. Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher J. Lord, Rachael Natrajan
Summary: SF3B1 mutations confer sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi). Mechanistically, this is independent of homologous recombination repair and instead relies on a defective replication stress response due to a reduction of the cyclin-dependent kinase 2 interacting protein (CINP). PARPi treatment of SF3B1 mutant (SF3B1(MUT)) tumors leads to replication stress induced by increased fork origin firing and culminates in cell cycle stalling. SF3B1 hotspot mutations are associated with a poor prognosis in several tumor types and lead to global disruption of canonical splicing.
