Article
Chemistry, Multidisciplinary
Jae-Hwan Oh, Jung-Hyuk Kwon, Hye-Hyun Kim, Jeewon Lee
Summary: This study aims to develop an advanced one-step immunoassay for quick and accurate diagnosis of sepsis by measuring PCT concentration in patient sera. By attaching multiple anti-PCT antibodies (IgGs) to a modified hepatitis B virus (HBV) capsid surface to construct a 3D probe, hook effect-free and PCT concentration-dependent optical signals were successfully generated.
Article
Pediatrics
Ummuhan Oncul, Nazan Dalgic, Mesut Demir, Pinar Karadeniz, Cetin Ali Karadag
Summary: Infection and sepsis are the main causes of morbidity and mortality in burn injuries. Diagnosing sepsis in burns is challenging due to the overlapping signs and symptoms with burn injury. This study aimed to investigate the role of procalcitonin (PCT) in distinguishing sepsis in pediatric burns.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Jipeng Shi, Zhen-Qi Lu, Qing-Mei Lin, Wang Zeng, Ping-Jiao Gu, Qing Yu, Jing Long, Da-Gui Huang, Yi-Heng Dai
Summary: This study aimed to determine whether the combination of albumin (ALB), C-reactive protein (CRP), and procalcitonin (PCT) is useful for the early diagnosis of neonatal sepsis. The results showed that the combination of ALB, CRP, and PCT is more reliable than CRP, PCT, or CRP+PCT alone, and can better diagnose neonatal sepsis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Pediatrics
Gabriella Bottari, Mariangela Caruso, Emanuel Paionni, Maia De Luca, Lorenza Romani, Mara Pisani, Annalisa Grandin, Livia Gargiullo, Giorgio Zampini, Chiara Gagliardi, Danilo Alunni Fegatelli, Annarita Vestri, Laura Lancella, Ottavia Porzio, Andrea Onetti Muda, Alberto Villani, Marta Ciofi Degli Atti, Massimiliano Raponi, Corrado Cecchetti
Summary: PSP can differentiate sepsis from non-infectious systemic inflammation, but our findings require validation in a larger pediatric population.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Critical Care Medicine
Jerome Pugin, Thomas Daix, Jean-Luc Pagani, Davide Morri, Angelo Giacomucci, Pierre-Francois Dequin, Christophe Guitton, Yok-Ai Que, Gianluca Zani, David Brealey, Alain Lepape, Ben Creagh-Brown, Duncan Wyncoll, Daniela Silengo, Irina Irincheeva, Laurie Girard, Fabien Rebeaud, Iwan Maerki, Philippe Eggimann, Bruno Francois
Summary: Serial measurements of CRP, PCT, and PSP showed potential for early recognition of sepsis in ICU patients. The increase in biomarker values before clinical sepsis diagnosis suggests their usefulness in early detection. Further evaluation of serial PSP measurement is warranted for managing critically ill patients with nosocomial sepsis.
Article
Multidisciplinary Sciences
Christian Gosset, Jacques Foguenne, Mickael Simul, Olivier Tomsin, Hayet Ammar, Nathalie Layios, Paul B. Massion, Pierre Damas, Andre Gothot
Summary: This study used flow cytometric data as a biomarker of bloodstream infection and developed an iDAR score with high specificity to identify bacteremia in ICU patients. The machine learning approach translated changes in myeloid cell phenotype into a score that could effectively differentiate infected from noninfected patients.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
NagaSpurthy Reddy Anugu, Safeera Khan
Summary: Procalcitonin is a useful biomarker in the prompt diagnosis of neonatal sepsis, with better correlation with proven sepsis and being an early biomarker for diagnosing neonatal sepsis. Future clinical trials are needed to determine optimal cut-off levels of procalcitonin with shifting neonatal ages and its use in the post-op setting.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Elena Maria Alessandra Mantovani, Paolo Formenti, Stefano Pastori, Vincenzo Roccaforte, Miriam Gotti, Rossella Panella, Andrea Galimberti, Roberto Costagliola, Francesco Vetrone, Michele Umbrello, Angelo Pezzi, Giovanni Sabbatini
Summary: The diagnosis of sepsis is difficult and delayed, leading to high mortality rates. The study evaluated the role of Neutrophil-Reactive Intensity (NEUT-RI) in the diagnosis of sepsis. NEUT-RI can be used as an early indicator to rule out sepsis and is not influenced by renal function.
Review
Pharmacology & Pharmacy
Benjamin A. August, Pramodini B. Kale-Pradhan, Christopher Giuliano, Leonard B. Johnson
Summary: Managing critically ill patients with infection requires the use of biomarkers such as procalcitonin and CRP to guide antimicrobial therapy. However, the literature on the use of these biomarkers is complicated due to heterogeneous populations and incongruent methodology. Although procalcitonin-guided therapy appears to be safe and effective, more studies are needed for CRP.
Review
Critical Care Medicine
Pedro Povoa, Luis Coelho
Summary: Diagnosing infection in patients with suspected sepsis is often challenging and relies on a combination of systemic manifestations, organ dysfunction, and microbiological documentation. Current criteria for diagnosis are imperfect, leading to overuse and misuse of antibiotics, as well as contributing to antibiotic resistance. Biomarkers have been studied as potential tools to improve diagnostic accuracy and guide antibiotic treatment decisions in various clinical scenarios. New evidence suggests that biomarkers can support suspicion of infection, aid pathogen identification, and help exclude infection, but the ideal biomarker has yet to be found.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Serife Kurul, Sinno H. P. Simons, Christian R. B. Ramakers, Yolanda B. De Rijke, Rene F. Kornelisse, Irwin K. M. Reiss, H. Rob Taal
Summary: Serum IL-6 and PCT levels at the moment of suspected late onset neonatal sepsis offer valuable information about sepsis severity and mortality risk in preterm infants. These biomarkers have a superior discriminative value compared to CRP and may help identify patients requiring more intensive monitoring and therapy.
Article
Clinical Neurology
Yan Chen, Zhanghua Yin, Xiaohui Gong, Jing Li, Wenhua Zhong, Liqin Shan, Xiaoping Lei, Qian Zhang, Qin Zhou, Youyan Zhao, Chao Chen, Yongjun Zhang
Summary: The study developed a sequential algorithm integrating clinical and laboratory parameters to stratify the risk of BM in neonates, showing excellent predictive performance and proving to be helpful for clinicians in decision-making related to LP.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Ji Eun Shin, Kyung Deok Seo, Hyun Jae Cha, Jong Wook Lee, Youn Moo Heo, Kwang Kyoun Kim, Tae Gyun Kim, Chan Kang, Gi Soo Lee, Jae Hwang Song
Summary: This study found that the delta neutrophil index is the best predictor of surgical treatment for patients with foot and ankle infections, helping clinicians make decisions at the right time.
Article
Critical Care Medicine
Iraklis Tsangaris, Nikolaos Antonakos, Massimo Fantoni, Gilles Kaplanski, Evdoxia Kyriazopoulou, Francisco Veas, Mark Clemens
Summary: Accurate assessment of severity and prognosis is crucial for optimizing the management of septic patients. Circulating biomarkers such as ultrasensitive detection of bacteremia, suPAR, CRP, ferritin, and procalcitonin have been used for improved evaluation. Novel multiwavelength optical biosensor technology allows noninvasive monitoring of metabolites to assess severity and prognosis in septic patients, offering potential for personalized management.
Article
Medicine, General & Internal
Yi-Hsuan Tang, Mei-Jy Jeng, Hsin-Hui Wang, Pei-Chen Tsao, Wei-Yu Chen, Yu-Sheng Lee
Summary: Detecting and predicting bacteremic sepsis in preterm and term neonates is challenging. This study identified different risk factors and predictive markers for early-onset and late-onset neonatal sepsis. PCT and PLT count were accurate diagnostic serum markers for early-onset sepsis, while WBC count was useful for late-onset sepsis.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Michel D. Kazatchkine, Michel Goldman, Jean-Louis Vincent
Editorial Material
Microbiology
Jean-Louis Vincent
FUTURE MICROBIOLOGY
(2021)
Letter
Critical Care Medicine
Jean-Louis Vincent, Jacques Creteur
INTENSIVE CARE MEDICINE
(2021)
Article
Critical Care Medicine
Wasineenart Mongkolpun, Peter Bakos, Jean-Louis Vincent, Jacques Creteur
Summary: This study included 42 patients with shock, and found that baseline skin blood flow and its early reduction after initiation of fluid removal using CVVH can predict worsened tissue perfusion, reflected by an increase in blood lactate levels.
ANNALS OF INTENSIVE CARE
(2021)
Review
Medicine, General & Internal
Jean-Louis Vincent, Jacques Creteur
Summary: With increasing life expectancy, more elderly patients are being admitted to ICU, representing a unique subgroup with changes in organ function, reduced daily living activities, decreased mobility, and cognitive decline. Ethical decisions regarding intensive care, life-sustaining interventions, life support withdrawal/withholding, and terminal sedation are more common in elderly patients, and should be personalized to consider individual beliefs and wishes.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jean-Louis Vincent
Summary: Intensive care units (ICUs) worldwide have faced significant challenges due to the COVID-19 pandemic, such as resource shortages and ethical dilemmas. Through the discussions prompted by the COVID-19 situation, valuable lessons can be learned about resource allocation, end-of-life decision-making, and staff support.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fabio Silvio Taccone, Fuhong Su, Xinrong He, Lorenzo Peluso, Katia Donadello, Sabino Scolletta, Daniel De Backer, Jean-Louis Vincent
Summary: The effects of correcting hypotension with vasopressors in septic shock may improve cerebral oxygenation but do not reverse the alterations in brain microcirculation or cerebral metabolism.
Review
Virology
Maya Hites, Jean-Louis Vincent
Summary: This article reviews the clinical studies conducted in Belgium on hospitalized patients with COVID-19, showing a limited participation of hospitals, low international collaboration, and a lack of adaptive platform trials.
Article
Neurosciences
Katia Donadello, Fuhong Su, Filippo Annoni, Sabino Scolletta, Xinrong He, Lorenzo Peluso, Leonardo Gottin, Enrico Polati, Jacques Creteur, Olivier De Witte, Jean-Louis Vincent, Daniel De Backer, Fabio Silvio Taccone
Summary: This study investigated the effects of cooling on cerebral microcirculation, oxygenation and metabolism in a healthy swine model. The results showed that during the cooling phase, cerebral functional capillary density and proportion of small-perfused vessels decreased, while oxygenation increased and metabolism decreased. After rewarming, all variables returned to normal values, except for an increased metabolism in the two groups subjected to hypothermia during the rewarming phase compared to the normothermia group.
Review
Biochemistry & Molecular Biology
Jean-Louis Vincent, Tom van der Poll, John C. Marshall
Summary: Sepsis, a life-threatening organ dysfunction caused by an uncontrolled host response to infection, remains a major challenge for clinicians and trialists. The evaluation of therapeutics targeting components of host response anomalies in sepsis patients is complicated by the inability to identify those who are more likely to benefit from a specific intervention. Furthermore, the existence of multiple and diverse host response aberrations in sepsis and limited knowledge of the dysregulated biological organ system or pathway driving sepsis-induced pathology in individual patients further complicate the development of effective therapies.
Article
Infectious Diseases
Jean-Louis Vincent
Summary: Sepsis is an infection associated with organ dysfunction, and early recognition and assessment of severity are crucial.
Correction
Critical Care Medicine
Alberto Fogagnolo, Fabio Silvio Taccone, Jean Louis Vincent, Giulia Benetto, Elaine Cavalcante, Elisabetta Marangoni, Riccardo Ragazzi, Jacques Creteur, Carlo Alberto Volta, Savino Spadaro
Review
Critical Care Medicine
Carlos A. Santacruz, Jean-Louis Vincent, Andres Bader, Luis A. Rincon-Gutierrez, Claudia Dominguez-Curell, David Communi, Fabio S. Taccone
Summary: Studies suggest that altered CSF concentrations of protein biomarkers related to cytoskeletal damage, inflammation, apoptosis, and oxidative stress may predict worse neurological outcomes in patients with acute brain injuries.
Article
Critical Care Medicine
Jean-Louis Vincent, Nicole P. Juffermans, Karen E. A. Burns, V. Marco Ranieri, Chryssa Pourzitaki, Francesca Rubulotta
Summary: There is a significant gender gap in critical care medicine, with women being underrepresented, but gender diversity has beneficial effects. The article discusses the reasons behind gender imbalance and proposes solutions, emphasizing the need to address and eliminate this issue.
Article
Critical Care Medicine
Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur, Maurizio Cecconi
Summary: The current coronavirus pandemic has heavily impacted ICUs worldwide, putting immense pressure on healthcare systems and staff. It is important to learn from both the positive and negative aspects of the response to improve organization and patient care in the future.