Review
Pharmacology & Pharmacy
Alexander Schuhmacher, Alexander Gatto, Michael Kuss, Oliver Gassmann, Markus Hinder
Summary: The study found that machine learning is the dominant AI technology used in pharmaceutical R&D. Both Big Techs and AI startups serve as competent knowledge bases for AI applications, with the former offering more general IT solutions while the latter provides more specific services in drug-discovery space.
DRUG DISCOVERY TODAY
(2021)
Article
Multidisciplinary Sciences
Di Wu, Su Wang, Senhao Chang, Guiyu Lian, Yuwen Chen
Summary: This study analyzed and compared the impacts of external and internal R&D on S&T output in China's pharmaceutical industry, and concluded that internal R&D can boost S&T output.
Review
Pharmacology & Pharmacy
Alexander Schuhmacher, Lucas Wilisch, Michael Kuss, Andreas Kandelbauer, Markus Hinder, Oliver Gassmann
Summary: Comparative analysis of the R&D efficiency of 14 leading pharmaceutical companies for the years 1999-2018 shows a close positive correlation between R&D spending and the output parameters, as well as economies of scale in pharmaceutical R&D.
DRUG DISCOVERY TODAY
(2021)
Review
Pharmacology & Pharmacy
Alexander Schuhmacher, Markus Hinder, Alexander von Stegmann und Stein, Dominik Hartl, Oliver Gassmann
Summary: We analyzed the R & D input, output, and outcome of 16 leading research-based pharmaceutical companies over 20 years (2001-2020). Our analysis shows that pharma companies increased their R & D spending at a compound annual growth rate of 6% (2001-2020) to an average R & D expenditure per company of $6.7 billion (2020). The companies in our investigation launched 251 new drugs representing 46% of all CDER-related FDA approvals in the past 20 years. The average R & D efficiency of big pharma was $6.16 billion total R & D expenditures per new drug. Almost half of the leading companies needed to compensate for their negative R & D productivity through mergers and acquisitions.
DRUG DISCOVERY TODAY
(2023)
Article
Spectroscopy
Manya Mittal, Kritika Sharma, Anurag Rathore
Summary: This paper introduces a method for rapid fingerprinting of pharmaceutical products using ATR mid-infrared spectroscopy, with antibiotics as a case study demonstrating its utility. The results show that the developed model can accurately predict the type and brand of antibiotics in pharmaceutical formulations.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Green & Sustainable Science & Technology
Rui Wang, Yonglong Lu, Shuai Song, Shengjie Yang, Yanqi Wu, Haotian Cui
Summary: This study proposes a fast and low-cost estimation method for industrial source discharge of PPCPs, which is validated by comparing the estimated results with existing monitoring data. The study finds that the discharge intensity of highly industrialized eastern provinces in China is significantly higher than that of western and northern provinces.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Medicine, General & Internal
Laila M. Sherief, Adel Ali, Ahmed Gaballa, Ghada Mohammed Abdellatif, Naglaa M. Kamal, Mona R. Afify, Diana H. Abdelmalek, Sameh A. El-Emari, Ahmed S. A. Soliman, Wesam A. Mokhtar
Summary: Vitamin D deficiency is highly prevalent among healthy Egyptian adolescents, with girls being more affected than boys. Lack of physical activity and sun exposure are significant factors associated with this deficiency. Vitamin D supplementation is recommended to address the issue.
Review
Medicine, General & Internal
Alessandra Borgheresi, Federica De Muzio, Andrea Agostini, Letizia Ottaviani, Alessandra Bruno, Vincenza Granata, Roberta Fusco, Ginevra Danti, Federica Flammia, Roberta Grassi, Francesca Grassi, Federico Bruno, Pierpaolo Palumbo, Antonio Barile, Vittorio Miele, Andrea Giovagnoni
Summary: The assessment of nodal involvement in rectal cancer patients is crucial for disease management, but the traditional dimensional and morphological criteria have limitations. Various imaging techniques have been introduced to improve the accuracy of nodal staging, and radiomics analysis has provided valuable evidence. Additionally, there are differences in recommendations for nodal evaluation in rectal cancer between European and North American guidelines.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Economics
Dimitrios Kourouklis
Summary: The study shows that public subsidies have a positive impact on drug development, particularly on Phase I clinical trials for nonorphan drugs and orphan medicinal products. Meanwhile, foreign government funding and market size have a minimal effect on pharmaceutical innovation.
Review
Pharmacology & Pharmacy
Ebtisam Alharbi, Rigina Skeva, Nick Juty, Caroline Jay, Carole Goble
Summary: The FAIR (findable, accessible, interoperable and reusable) principles are guidelines that aim to increase the effective use of scientific research data. Adhering to these principles in pharmaceutical research and development (R&D) can maximize the value of data assets, but comes with challenges and costs. The 'FAIR-Decide' framework uses business analysis techniques to estimate costs and benefits, providing support for decision-making on FAIRification in the pharmaceutical R&D industry and integration into data management strategies.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Dariusz Boczar, Katarzyna Michalska
Summary: This article reviews the complexation of cyclodextrins (CDs) with antibiotics and antibacterial agents, focusing on their drug-delivery applications such as improving drug properties, controlling drug release, and enhancing antimicrobial activity.
Review
Environmental Sciences
Aliyu Zakari-Jiya, Chiara Frazzoli, Cecilia Nwadiuto Obasi, Bolaji Bernard Babatunde, Kingsley C. Patrick-Iwuanyanwu, Orish E. Orisakwe
Summary: The use of pharmaceuticals and personal care products in Nigeria has raised concerns about their impact on the environment and ecology. Studies have identified a wide range of these products in surface and ground water, highlighting the need for legislation, toxicological profiling, and awareness on proper use and disposal.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Health Care Sciences & Services
Angelina Bania, Konstantinos Pitsikakis, Georgios Mavrovounis, Maria Mermiri, Eleftherios T. Beltsios, Antonis Adamou, Vasiliki Konstantaki, Demosthenes Makris, Vasiliki Tsolaki, Konstantinos Gourgoulianis, Ioannis Pantazopoulos
Summary: This systematic review examines the efficacy of vitamin D administration in adult patients with COVID-19. The results show that vitamin D supplements, especially calcifediol, have a significant effect in reducing ICU admissions and mortality rates. However, the effect on the duration of hospitalization is still unclear.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Business
Raffaele Silvestri, Roberta Bocconcelli, Elisa Carloni, Alessandro Pagano
Summary: This study provides an in-depth analysis of how cluster firms participate in cluster-promoted R&D IOPs and the main effects of their involvement on the development of technological and organizational resources. The study shows that the cluster-promoted IOP itself is a valuable organizational resource, and its effectiveness is influenced by a shared cluster identity.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Lorenzo Costantini, Francesco Laio, Luca Ridolfi, Carla Sciarra
Summary: Research and Development (R&D) is crucial for innovation, technological progress, sustainable development, and economic growth. In this study, a new perspective is introduced to analyze international trade by incorporating R&D and industrial activities. New indices, RDE and RDI, are proposed to summarize the R&D content of countries' export and import baskets, providing insights into the evolution of R&D choices and their impact on trade, innovation, and development. These indices offer complementary information to traditional measures of development and economic growth and can help explore the relationship between environmental performance and countries' role in international trade.
SCIENTIFIC REPORTS
(2023)
