Targeting the p53 signaling pathway in cancer therapy – the promises, challenges and perils
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Title
Targeting the p53 signaling pathway in cancer therapy – the promises, challenges and perils
Authors
Keywords
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Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 16, Issue 1, Pages 67-83
Publisher
Informa Healthcare
Online
2012-01-12
DOI
10.1517/14728222.2011.643299
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Note: Only part of the references are listed.- Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts
- (2011) Cyrus Chargari et al. CANCER LETTERS
- What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator
- (2011) Alexander H. Stegh et al. CELL CYCLE
- Beyond effector caspase inhibition
- (2011) Alexander H. Stegh et al. CELL CYCLE
- Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
- (2011) Ian R. Hardcastle et al. JOURNAL OF MEDICINAL CHEMISTRY
- Removing all obstacles: A critical role for p53 in promoting tissue renewal
- (2010) David W. Schoppy et al. CELL CYCLE
- INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect
- (2010) Alberto A Chiappori et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor
- (2010) A. H. Stegh et al. GENES & DEVELOPMENT
- Alternative cell death mechanisms in development and beyond
- (2010) J. Yuan et al. GENES & DEVELOPMENT
- Identification and Characterization of the First Small Molecule Inhibitor of MDMX
- (2010) Damon Reed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53
- (2010) Mark Demma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
- (2010) Andrea Alimonti et al. JOURNAL OF CLINICAL INVESTIGATION
- The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias
- (2010) K. Kojima et al. MOLECULAR CANCER THERAPEUTICS
- A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis
- (2010) H. Wang et al. MOLECULAR CANCER THERAPEUTICS
- Selective activation of p53-mediated tumour suppression in high-grade tumours
- (2010) Melissa R. Junttila et al. NATURE
- Stage-specific sensitivity to p53 restoration during lung cancer progression
- (2010) David M. Feldser et al. NATURE
- p53 isoforms gain functions
- (2010) V Olivares-Illana et al. ONCOGENE
- Pharmacological reactivation of mutant p53: from protein structure to the cancer patient
- (2010) K G Wiman ONCOGENE
- Tamoxifen-induced apoptosis of rat C6 glioma cells via PI3K/Akt, JNK and ERK activation
- (2010) Xie ONCOLOGY REPORTS
- The p53 orchestra: Mdm2 and Mdmx set the tone
- (2010) Mark Wade et al. TRENDS IN CELL BIOLOGY
- Transcriptional Regulation by P53
- (2010) R. Beckerman et al. Cold Spring Harbor Perspectives in Biology
- Multiple hepatic arterial injections of recombinant adenovirus p53 and 5-fluorouracil after transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: a pilot phase II trial
- (2009) Geng Tian et al. ANTI-CANCER DRUGS
- Functions of p53 in metabolism and invasion:
- (2009) Karen H. Vousden BIOCHEMICAL SOCIETY TRANSACTIONS
- Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis
- (2009) Maria A. Lebedeva et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML
- (2009) B. Z. Carter et al. BLOOD
- Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism
- (2009) P. Secchiero et al. BLOOD
- PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
- (2009) Jeremy M.R. Lambert et al. CANCER CELL
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
- The multiple levels of regulation by p53 ubiquitination
- (2009) J T Lee et al. CELL DEATH AND DIFFERENTIATION
- In vitro and Clinical Studies of Gene Therapy with Recombinant Human Adenovirus-p53 Injection for Oral Leukoplakia
- (2009) Y. Li et al. CLINICAL CANCER RESEARCH
- Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck
- (2009) J. Nemunaitis et al. CLINICAL CANCER RESEARCH
- MDM2 Antagonist Nutlin-3 Displays Antiproliferative and Proapoptotic Activity in Mantle Cell Lymphoma
- (2009) Y. Tabe et al. CLINICAL CANCER RESEARCH
- Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer
- (2009) F. M. Speetjens et al. CLINICAL CANCER RESEARCH
- Sister chromatid tension and the spindle assembly checkpoint
- (2009) Luigi Nezi et al. CURRENT OPINION IN CELL BIOLOGY
- Reactive Oxygen Species-independent Oxidation of Thioredoxin in Hypoxia
- (2009) Harish Muniyappa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
- (2009) Jason Phan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clinical study of recombinant adenovirus-p53 combined with fractionated stereotactic radiotherapy for hepatocellular carcinoma
- (2009) Zhi-xiang Yang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
- (2009) Weimin Chen et al. MOLECULAR CELL
- Epidermal homeostasis: a balancing act of stem cells in the skin
- (2009) Cédric Blanpain et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage
- (2009) H.-C. Tu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
- (2009) S. Sur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p53 Regulation of Metabolic Pathways
- (2009) E. Gottlieb et al. Cold Spring Harbor Perspectives in Biology
- The Origins and Evolution of the p53 Family of Genes
- (2009) V. A. Belyi et al. Cold Spring Harbor Perspectives in Biology
- Clinical Outcomes and Correlates of TP53 Mutations and Cancer
- (2009) A. I. Robles et al. Cold Spring Harbor Perspectives in Biology
- Tumor Suppressive Functions of p53
- (2009) J. T. Zilfou et al. Cold Spring Harbor Perspectives in Biology
- TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
- (2009) M. Olivier et al. Cold Spring Harbor Perspectives in Biology
- Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy
- (2008) Sanjeev Shangary et al. Annual Review of Pharmacology and Toxicology
- Tumor Protein 53-Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function
- (2008) C. E. Cano et al. CANCER RESEARCH
- Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
- (2008) Stuart H. Orkin et al. CELL
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- (2008) L Weinmann et al. CELL DEATH AND DIFFERENTIATION
- Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo
- (2008) M A Tyler et al. GENE THERAPY
- Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)
- (2008) Hua Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma
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- Phase I Study of Adenovirus p53 Administered by Bronchoalveolar Lavage in Patients With Bronchioloalveolar Cell Lung Carcinoma: ECOG 6597
- (2008) Vicki Keedy et al. JOURNAL OF CLINICAL ONCOLOGY
- Effect of Recombinant Adenovirus-p53 Combined With Radiotherapy on Long-Term Prognosis of Advanced Nasopharyngeal Carcinoma
- (2008) Jian-ji Pan et al. JOURNAL OF CLINICAL ONCOLOGY
- Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
- (2008) Sanjeev Shangary et al. MOLECULAR CANCER THERAPEUTICS
- p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
- (2008) Keiko Kawauchi et al. NATURE CELL BIOLOGY
- PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2
- (2008) J Shen et al. ONCOGENE
- Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway
- (2008) J. E. Kravchenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma
- (2008) A. H. Stegh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
- (2008) S. Shangary et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence
- (2008) T. M. Johnson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
- (2008) F. M. Boeckler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mesenchymal Stem Cells Effectively Deliver an Oncolytic Adenovirus to Intracranial Glioma
- (2008) Adam M. Sonabend et al. STEM CELLS
- The BCL-2 protein family: opposing activities that mediate cell death
- (2007) Richard J. Youle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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