Class 3 semaphorins as a therapeutic target

Expression of class 3 semaphorins and their receptors in human breast neoplasia

(2015) Carolyn A Staton et al.   HISTOPATHOLOGY

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

(2012) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model

(2012) Tomoko Okawa et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis

(2012) Osamu Negi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Collapsin Response Mediator Proteins Regulate Neuronal Development and Plasticity by Switching Their Phosphorylation Status

(2012) Naoya Yamashita et al.   MOLECULAR NEUROBIOLOGY

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Semaphorin 3A Suppresses Tumor Growth and Metastasis in Mice Melanoma Model

(2012) Goutam Chakraborty et al.   PLoS One

Diverse roles for semaphorin−plexin signaling in the immune system

(2012) Hyota Takamatsu et al.   TRENDS IN IMMUNOLOGY

Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Progression in Mouse Tumor Models

(2011) Andrea Casazza et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Semaphorin 3A lytic hybrid peptide binding to neuropilin-1 as a novel anti-cancer agent in pancreatic cancer

(2011) Hanae Ueyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A

(2011) J.-S. Joyal et al.   BLOOD

Endogenous Axon Guiding Chemorepulsant Semaphorin-3F Inhibits the Growth and Metastasis of Colorectal Carcinoma

(2011) F. Wu et al.   CLINICAL CANCER RESEARCH

The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1

(2011) Szu-Hua Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

(2011) Maxime Cazorla et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of CNS Remyelination by the Presence of Semaphorin 3A

(2011) Y. A. Syed et al.   JOURNAL OF NEUROSCIENCE

Intranasal Administration of Semaphorin-3A Alleviates Sneezing and Nasal Rubbing in a Murine Model of Allergic Rhinitis

(2011) Haruna Sawaki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Semaphorin 3A Attenuates Electrical Remodeling at Infarct Border Zones in Rats after Myocardial Infarction

(2011) Hua-Zhi Wen et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cells

(2010) Hongjie Pan et al.   EXPERIMENTAL CELL RESEARCH

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Plexin-A4–semaphorin 3A signaling is required for Toll-like receptor– and sepsis-induced cytokine storm

(2010) Haitao Wen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Neuroimmune Semaphorin-3A Reduces Inflammation and Progression of Experimental Autoimmune Arthritis

(2010) A. Catalano   JOURNAL OF IMMUNOLOGY

Collapsin Response Mediator Protein 4a (CRMP4a) Is Upregulated in Motoneurons of Mutant SOD1 Mice and Can Trigger Motoneuron Axonal Degeneration and Cell Death

(2010) L. Duplan et al.   JOURNAL OF NEUROSCIENCE

Structural basis of semaphorin–plexin signalling

(2010) Bert J. C. Janssen et al.   NATURE

Structural basis for semaphorin signalling through the plexin receptor

(2010) Terukazu Nogi et al.   NATURE

Mical links semaphorins to F-actin disassembly

(2010) Ruei-Jiun Hung et al.   NATURE

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

(2010) Hyota Takamatsu et al.   NATURE IMMUNOLOGY

A role for class 3 semaphorins in prostate cancer

(2010) V. Blanc et al.   PROSTATE

A Semaphorin 3A Inhibitor Blocks Axonal Chemorepulsion and Enhances Axon Regeneration

(2009) Marisol Montolio et al.   CHEMISTRY & BIOLOGY

Role of Class 3 Semaphorins and Their Receptors in Tumor Growth and Angiogenesis

(2009) P. Gaur et al.   CLINICAL CANCER RESEARCH

Differential expression of the semaphorin 3A pathway in prostatic cancer

(2009) Mokrane Yacoub et al.   HISTOPATHOLOGY

Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis

(2009) Mitsutoshi Tominaga et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Tumor Suppressor p53 Transcriptionally Regulates cGKI Expression during Neuronal Maturation and Is Required for cGMP-Dependent Growth Cone Collapse

(2009) A. Tedeschi et al.   JOURNAL OF NEUROSCIENCE

Autocrine semaphorin 3A signaling promotes glioblastoma dispersal

(2009) T Bagci et al.   ONCOGENE

Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration

(2009) H. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semaphorin3A immunohistochemical expression in human meningiomas: correlation with the microvessel density

(2009) Valeria Barresi et al.   VIRCHOWS ARCHIV

Semaphorin 3E Expression Correlates Inversely with Plexin D1 During Tumor Progression

(2008) Ilse Roodink et al.   AMERICAN JOURNAL OF PATHOLOGY

Sustained up-regulation of Semaphorin 3A, Neuropilin1, and Doublecortin expression in ischemic mouse brain during long-term recovery

(2008) Sheng T. Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells

(2008) Hongjie Pan et al.   BREAST CANCER RESEARCH AND TREATMENT

Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis

(2008) M. Tominaga et al.   BRITISH JOURNAL OF DERMATOLOGY

Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: Implications for autism and epilepsy

(2008) John C. Gant et al.   EPILEPSIA

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

(2008) Milka Sarris et al.   IMMUNITY

Semaphorin3A Alleviates Skin Lesions and Scratching Behavior in NC/Nga Mice, an Atopic Dermatitis Model

(2008) Junko Yamaguchi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Successful Inhibition of Tumor Development by Specific Class-3 Semaphorins Is Associated with Expression of Appropriate Semaphorin Receptors by Tumor Cells

(2008) Boaz Kigel et al.   PLoS One

Semaphorin signaling: progress made and promises ahead

(2008) Yeping Zhou et al.   TRENDS IN BIOCHEMICAL SCIENCES