Exploiting p70 S6 kinase as a target for ovarian cancer

Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors

(2012) Joerg Bussenius et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways

(2011) Ting-Chun Kuo et al.   BIOCHEMICAL PHARMACOLOGY

Dual blockade of phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer

(2011) Rui Xu et al.   CANCER LETTERS

The cdk1-cyclin B complex is involved in everolimus triggered resistance in the PC3 prostate cancer cell line

(2011) Igor Tsaur et al.   CANCER LETTERS

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

(2011) Katarzyna Jastrzebski et al.   CELLULAR SIGNALLING

Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer

(2011) Jae Hong No et al.   GYNECOLOGIC ONCOLOGY

Weekly administration of temsirolimus for heavily pretreated patients with clear cell carcinoma of the ovary: a report of six cases

(2011) Masashi Takano et al.   International Journal of Clinical Oncology

PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth

(2011) J. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells

(2011) C K M Ip et al.   ONCOGENE

Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR

(2011) M Rosner et al.   ONCOGENE

MiR-223 Suppresses Cell Proliferation by Targeting IGF-1R

(2011) Cheng You Jia et al.   PLoS One

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

(2011) B. T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of glycolysis enhances cisplatin-induced apoptosis in ovarian cancer cells

(2010) Paul Loar et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

S6K1 is acetylated at lysine 516 in response to growth factor stimulation

(2010) Tim R. Fenton et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

P70S6K 1 regulation of angiogenesis through VEGF and HIF-1α expression

(2010) Chuan-Xiu Bian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

(2010) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling

(2010) Xin He et al.   CANCER LETTERS

S6K1 Plays a Critical Role in Early Adipocyte Differentiation

(2010) Larissa S. Carnevalli et al.   DEVELOPMENTAL CELL

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

(2010) Keng Po Lai et al.   EMBO JOURNAL

Functions and regulation of the 70kDa ribosomal S6 kinases

(2010) Tim R. Fenton et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma

(2010) Alejandro G. Levy et al.   INVESTIGATIONAL NEW DRUGS

AT7867 Is a Potent and Oral Inhibitor of AKT and p70 S6 Kinase That Induces Pharmacodynamic Changes and Inhibits Human Tumor Xenograft Growth

(2010) K. M. Grimshaw et al.   MOLECULAR CANCER THERAPEUTICS

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway

(2010) Myung Sun Lee et al.   PHYTOTHERAPY RESEARCH

MEK1-independent activation of MAPK and MEK1-dependent activation of p70 S6 kinase by stem cell factor (SCF) in ovarian cancer cells

(2009) Lian Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteolytic Cleavage of p70 Ribosomal S6 Kinase by Caspase-3 during DNA Damage-Induced Apoptosis†

(2009) Rohini Dhar et al.   BIOCHEMISTRY

Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation

(2009) Tomoko Sunami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitor hijacking of Akt activation

(2009) Tatsuya Okuzumi et al.   Nature Chemical Biology

Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1

(2008) Ganna Panasyuk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of ribosomal protein S6 kinases by ubiquitination

(2008) Mong-Lien Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

(2008) V. Serra et al.   CANCER RESEARCH

p70 S6 Kinase Promotes Epithelial to Mesenchymal Transition through Snail Induction in Ovarian Cancer Cells

(2008) Y. L. Pon et al.   CANCER RESEARCH

MicroRNA-223 Is Commonly Repressed in Hepatocellular Carcinoma and Potentiates Expression of Stathmin1

(2008) Queenie W.–L. Wong et al.   GASTROENTEROLOGY

The ubiquitination of ribosomal S6 kinases is independent from the mitogen-induced phosphorylation/activation of the kinase

(2008) J. Gwalter et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Potential role of miR-9 and miR-223 in recurrent ovarian cancer

(2008) Alexandros Laios et al.   Molecular Cancer